Pharmacological validation of Solanum mammosum L. as an anti-infective agent: Role of solamargine

Cabanillas, Billy; Chassagne, François; Vásquez-Ocmín, Pedro; Tahrioui, Ali; Chevalier, Sylvie; Vansteelandt, Marieke; Triastuti, Asih; Guerra, Carlos A. Amasifuén; Fabre, Nicolás; Haddad, Mohamed

doi:10.1016/j.jep.2021.114473

Cited by 13 publications

(13 citation statements)

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“…Solanum mammosum L. is a very toxic plant due to its composition in steroidal glycoalkaloids (e.g. solamargine) [ 173 ]. The yellow fruits of this shrub were sometimes the first fresh fruits that the hungry sailors saw in the seventeenth and eighteenth centuries when they finally arrived in Surinam after the long sea journey.…”

Section: Resultsmentioning

confidence: 99%

Female naturalists and the patterns of suppression of women scientists in history: the example of Maria Sibylla Merian and her contributions about useful plants

Mariath

Baratto

2023

J Ethnobiology Ethnomedicine

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Background This work reunites many women naturalists who registered knowledge about native flora in scientific expeditions around the globe between the seventeenth and nineteenth centuries. Since male naturalists are more recognized in this period of time, we aimed to list female naturalists that published plant descriptions and observations, focusing on the work of Maria Sibylla Merian and to analyze her trajectory as an example to discuss the patterns of the suppression of women scientists. A second aim was to inventory the useful plants described in Maria Sibylla’s Metamorphosis Insectorum Surinamensium and find pharmacological evidence about the traditional uses described for those plants cited as medicinal and toxic. Methods A survey of female naturalists was carried out by searching information in Pubmed, Scielo, Google Scholar and Virtual Health Library. Once Maria Sibylla published her book Metamorphosis Insectorum Surinamensium by her own, without male co-authors, and also this book is one of the only to have text and illustrations altogether and there are reports indicating information on useful plants in this work, she and her book were chosen as subject of this research. All the information was tabulated by dividing the plants into food, medicinal, toxic, aromatic or other uses. Finally, with the combinations of the scientific name of medicinal and toxic plants with information about their popular uses, a search was carried out in databases in order to indicate current pharmacological studies that reported evidences about the traditional uses described. Results We found 28 women naturalists who participated in scientific expeditions or trips, or in a curiosity cabinet, or who were collectors of Natural History between the seventeenth and nineteenth centuries. All these women illustrated botanical species and/or recorded their everyday or medicinal use or reported their observations in the form of a published work, letters or diaries. Also, the trajectory of Maria Sibylla Merian revealed that her scientific relevance has been neglected from the eighteenth century by mechanisms of suppression, most of the time by male depreciation, which can be seen as a pattern for suppression of women in science. However, Maria Sibyllas’ contributions have been valued again in the twenty-first century. In Maria Sibylla’s work, 54 plants were identified, 26 of them used for food, 4 of them aromatic, 8 medicinal, 4 toxic and 9 other uses. Conclusion This study evidences that there are female naturalists whose work could be an important source for ethnopharmacological studies. Researching about women scientists, talking about them and highlighting the gender bias present in the scientific academy about the way the history of science is told is essential for the construction of a more diverse and richer scientific academy. The traditional use of 7 of 8 medicinal plants and 3 of 4 toxic plants reported was correlated with pharmacological studies, highlighting the importance of this historical record and its potential to direct strategic research in traditional medicine.

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Section: Resultsmentioning

confidence: 99%

Female naturalists and the patterns of suppression of women scientists in history: the example of Maria Sibylla Merian and her contributions about useful plants

Mariath

Baratto

2023

J Ethnobiology Ethnomedicine

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“…Así también, el presente estudio demostró una actividad antifúngica moderada para C. albicans con valores de 125 µg/ mL, estos valores son menores a lo reportado en la especie de Solanum mammosum con valores de 256 µg/mL (30) . También se ha reportado actividad antifúngica frente a otras especies fúngicas como Aspergillus sp; como Solanum xantocarpum contra A. niger (10) , mostrando actividad antifúngica con CMI de 250 µg/mL, estos valores también han sido hallados en nuestro estudio (250 µg/mL) frente a A. brasiliensis.…”

Section: Discussionunclassified

“…También se ha reportado actividad antifúngica frente a otras especies fúngicas como Aspergillus sp; como Solanum xantocarpum contra A. niger (10) , mostrando actividad antifúngica con CMI de 250 µg/mL, estos valores también han sido hallados en nuestro estudio (250 µg/mL) frente a A. brasiliensis. Para el caso de Trichophyton mentagrophytes se evidenció la CMI de 125 µg/mL, resultados similares se reportaron con Solanum mammosum con valores de 256 µg/mL (30) para T. mentagrofphytes.…”

Section: Discussionunclassified

“…Muchas especies de la familia Solanaceae como Solanum chrysotrichum (6,7) , Solanum melogena (8) , Solanum nigrum (11) , Solanum xanthocarpum (23) y Solanum mammosum (30) también demostraron actividad antifúngica, es posible que esta se deba a la presencia de saponinas, alcaloides, esteroides y/o flavonoides, los cuales pueden actuar de manera individual o sinérgica por un mecanismo de acción aún desconocido.…”

Section: Discussionunclassified

“…Tanto los esteroides como los alcaloides presentan alta actividad biológica y son un grupo de compuestos cíclicos que han sido estudiados debido a sus efectos antimicrobianos, esto ha sido reafirmado a través del aislamiento de compuestos bioactivos con potente actividad antifúngica in vitro (30) .…”

Section: Discussionunclassified

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Análisis fitoquímico preliminar y actividad antifúngica In vitro del extracto etanólico de las hojas de Solanum hispidum pers. colectadas en la localidad Obraje - Perú

Mendoza-León

Ruitón

Arias

2022

Rev Peru Med Exp Salud Publica

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Objetivo. Analizar y determinar la actividad antifúngica in vitro del extracto etanólico de las hojas de Solanum hispidum Pers. Materiales y métodos. Se realizó el análisis fitoquímico preliminar cualitativo mediante reacciones de color y precipitación. Se investigó la actividad antifúngica in vitro frente a Candida albicans, Aspergillus brasilensis y Trichophyton mentagrophytes usando el método de difusión en pozo de agar y el ensayo de la concentración mínima inhibitoria (CMI). Resultados. El análisis fitoquímico preliminar cualitativo mostró la presencia de compuestos fenólicos, taninos, flavonoides, esteroides, alcaloides y saponinas. La actividad antifúngica in vitro fue demostrada para todos cultivos fúngicos con halos de inhibición entre 23 a 26 mm. Los valores de la CMI fueron de 125, 250 y 125 μg/mL para C. albicans, A. brasilensis y T. mentagrophytes, respectivamente. Conclusiones. El extracto etanólico de las hojas de Solanum hispidum Pers contiene importantes metabolitos secundarios y tiene moderada actividad antifúngica.

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Unveiling the Biological Activities, Pharmacological Potential, and Health Benefits of Sorbifolin: A Comprehensive Review

Belmehdi,

Mssillou,

Khalid

et al. 2024

Chemistry & Biodiversity

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Bioactive phytochemicals act as important factors with preventive and therapeutic potential in the pathogenesis of several disorders, often related to oxidative stress. Many dietary plant secondary metabolites could lower these conditions. Sorbifolin is one of these metabolites. This work is the first review of sorbifolin, a flavone detected in various plant matrices as a major compound. The present study discussed the natural sources, extraction, purification, quantification, and assessment of the biological activities of sorbifolin. Several databases including Google Scholar, Web of Sciences, and Science‐Direct were consulted for relevant English articles related to sorbifolin, the phytochemical profiles of several medicinal plants containing this compound, and its biological activities, such as antioxidant, anticancer, antimicrobial, anti‐inflammatory, and antidiabetic. The positive in vitro and in silico outcomes reported in the literature should be followed by additional in vivo and clinical investigations to further research the mechanisms of action, pharmacokinetic/pharmacodynamic activities, toxicological effects, pharmacological properties, and therapeutic potential of sorbifolin.

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Pharmacological validation of Solanum mammosum L. as an anti-infective agent: Role of solamargine

Cited by 13 publications

References 46 publications

Female naturalists and the patterns of suppression of women scientists in history: the example of Maria Sibylla Merian and her contributions about useful plants

Female naturalists and the patterns of suppression of women scientists in history: the example of Maria Sibylla Merian and her contributions about useful plants

Análisis fitoquímico preliminar y actividad antifúngica In vitro del extracto etanólico de las hojas de Solanum hispidum pers. colectadas en la localidad Obraje - Perú

Unveiling the Biological Activities, Pharmacological Potential, and Health Benefits of Sorbifolin: A Comprehensive Review

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