Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

Jancsó, Gábor; Király, Elisabeth; Jancsó-Gábor, A.

doi:10.1038/270741a0

Cited by 1,221 publications

(217 citation statements)

References 8 publications

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“…This leads to a substantial decrease (» 90 %) in the content of CGRP [4,8,9]. Subsequently, in adult rats which received neonatal capsaicin treatment there is a minimal release of sensory peptides from de-afferenated fibres.…”

Section: : 813±820]mentioning

confidence: 99%

Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats

1998

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Section: : 813±820]mentioning

confidence: 99%

Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats

1998

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“…Neonatal injection of high doses of capsaicin is well known to induce both a selective degeneration and functional ablation of CFEs (Jancso et al, 1977), which we previously confirmed in newborn lambs (Diaz et al, 1999). Accordingly, CFEs were blocked on the first recording afternoon by a subcutaneous injection of 25 mg/kg of capsaicin (diluted in 10% Tween 80, 10% ethanol and 80% physiological saline) under a 30-min general anesthesia.…”

Section: 2-surgical Instrumentation and Study Designmentioning

confidence: 91%

Laryngeal narrowing during nasal ventilation does not originate from bronchopulmonary C-fibers

Samson

Niane

Nault

et al. 2014

Respiratory Physiology & Neurobiology

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We previously showed that nasal pressure support ventilation (nPSV) can lead to active inspiratory laryngeal narrowing, which originates from the stimulation of bronchopulmonary receptors. Among the three major types of bronchopulmonary receptors, which are variably stimulated by lung distension, C-fiber endings are remarkable, given that their stimulation can also trigger laryngeal closure. Taking advantage of our lamb model with blocked C-fibers, we aimed to assess whether bronchopulmonary C-fiber endings are involved in the active inspiratory laryngeal narrowing during nPSV. Nine lambs were surgically instrumented to assess states of alertness, electrical activity of a glottal constrictor (EaTA), respiratory movements and arterial blood gases. Forty-eight hours later, two polysomnographic recordings were performed during nPSV 15/4 cmH 2 O, before and after C-fiber blockade. During nPSV, blockade of C-fibers did not prevent inspiratory EaTA (present for 74 ± 41% of respiratory cycles vs. 64 ± 35%, p = 0.9). We conclude that active inspiratory laryngeal narrowing during nPSV does not originate from bronchopulmonary C-fiber endings.

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“…This hypothermic effect is due, in part, to vasodilation and a fall in metabolic activity at cool temperatures [56]. However, when given systemically to neonatal rats, capsaicin induces the selective degeneration of small-diameter sensory neurons, leading to reduced vasodilation and the absence of systemic capsaicin-mediated reductions in body temperature [58]. Likewise, as in adults, capsaicin-treated rats are less responsive to stimulation with chemical irritants and noxious heat.…”

Section: The Hot Of Capsaicin and The Cool Of Mentholmentioning

confidence: 99%

Temperature sensing across species

McKemy

2007

Pflugers Arch - Eur J Physiol

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The ability to detect changes in temperature is a fundamental sensory mechanism for every species and provides organisms with a detailed view of the environment. This review focuses on what is known of the neuronal and molecular substrates for thermosensation across species, focusing on the three robust model systems extensively used to study sensory signaling, the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the laboratory mouse. Nematodes migrate to thermal climes that are amenable to their survival, a behavior that is regulated primarily through a single sensory neuron. Additionally, nematodes "learn" to seek out this temperate zone based upon their prior experience, a robust model of learning and memory. Drosophila larvae also prefer select thermal zones that are optimal for growth and have also developed vigorous mechanisms to avoid unfavorable conditions. In mammals, the transduction mechanisms for thermosensation have been identified primarily due to the fact that naturally occurring plant products evoke distinct psychophysical sensation of temperature change. More remarkably, the elucidation of the molecular sensors in mammals, along with those in Drosophila, has demonstrated conservation in the molecular mediators of temperature sensation across diverse species.

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Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

Cited by 1,221 publications

References 8 publications

Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats

Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats

Laryngeal narrowing during nasal ventilation does not originate from bronchopulmonary C-fibers

Temperature sensing across species

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