Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs

Maideen, Naina Mohamed Pakkir; Balasubramaniam, Rajkapoor

doi:10.15171/jhp.2018.32

Cited by 19 publications

(11 citation statements)

References 120 publications

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“… 3 Patients with type 2 diabetes are usually treated with oral antidiabetic drugs such as metformin, sulfonylureas, meglitinides, thiazolidinediones (TZDs), dipeptidyl peptidase 4 (DPP4) inhibitors and SGLT2 inhibitors. 4 5 …”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Maideen

2021

Chonnam Med J

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The use of herbal medicine to manage chronic conditions including diabetes has become a recent global trend. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. The present review is aimed to analyze the antidiabetic activity of N. sativa as many type 2 diabetic patients use it as a complementary therapy along with their modern allopathic medications or as an alternative therapy. The literature was reviewed in databases like Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, EMBASE, Directory of open access journals (DOAJ), and reference lists to identify relevant articles supporting the use of N. sativa in diabetes management. Numerous clinical and animal studies have demonstrated the antidiabetic efficacy of black seeds ( N. sativa ) and its major bioactive constituent thymoquinone. Based on these findings patients with diabetes may use N. sativa as an adjuvant therapy, which may help to reduce the dose and incidence of adverse effects of modern antidiabetic medicines.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Maideen

2021

Chonnam Med J

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“…It is characterized by an elevated blood glucose level due to defects in insulin secretion and insulin resistance, or both. DM is associated with eye, renal, cardiovascular, and neurological complications in the long term and is also associated with symptoms such as polyuria, fatigue, weight loss, delayed wound healing, blurred vision, increases in plasma and urine glucose levels [2][3][4]. Generally, DM can be categorized into two types; type 1 and type 2.…”

Section: Introductionmentioning

confidence: 99%

Characterization of α-Glucosidase Inhibitors from Psychotria malayana Jack Leaves Extract Using LC-MS-Based Multivariate Data Analysis and In-Silico Molecular Docking

et al. 2020

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Psychotria malayana Jack has traditionally been used to treat diabetes. Despite its potential, the scientific proof in relation to this plant is still lacking. Thus, the present study aimed to investigate the α-glucosidase inhibitors in P.malayana leaf extracts using a metabolomics approach and to elucidate the ligand–protein interactions through in silico techniques. The plant leaves were extracted with methanol and water at five various ratios (100, 75, 50, 25 and 0% v/v; water–methanol). Each extract was tested for α-glucosidase inhibition, followed by analysis using liquid chromatography tandem to mass spectrometry. The data were further subjected to multivariate data analysis by means of an orthogonal partial least square in order to correlate the chemical profile and the bioactivity. The loading plots revealed that the m/z signals correspond to the activity of α-glucosidase inhibitors, which led to the identification of three putative bioactive compounds, namely 5′-hydroxymethyl-1′-(1, 2, 3, 9-tetrahydro-pyrrolo (2, 1-b) quinazolin-1-yl)-heptan-1′-one (1), α-terpinyl-β-glucoside (2), and machaeridiol-A (3). Molecular docking of the identified inhibitors was performed using Auto Dock Vina software against the crystal structure of Saccharomyces cerevisiae isomaltase (Protein Data Bank code: 3A4A). Four hydrogen bonds were detected in the docked complex, involving several residues, namely ASP352, ARG213, ARG442, GLU277, GLN279, HIE280, and GLU411. Compound 1, 2, and 3 showed binding affinity values of −8.3, −7.6, and −10.0 kcal/mol, respectively, which indicate the good binding ability of the compounds towards the enzyme when compared to that of quercetin, a known α-glucosidase inhibitor. The three identified compounds that showed potential binding affinity towards the enzymatic protein in molecular docking interactions could be the bioactive compounds associated with the traditional use of this plant.

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“…Sulfonylureas are oral hypoglycemic agents employed in the treatment of type 2 diabetes mellitus and they include the drugs such as Glibenclamide, Gliclazide, Glipizide and others. 32,33 The risk of hypoglycemia was observed higher in patients taking Liraglutide along with sulfonylurea. 34 The dose of sulfonylurea is recommended to be halved when a GLP-1 agonist is initiated in a patient receiving Sulfonylurea to avoid hypoglycemic episodes.…”

Section: Sulfonylureasmentioning

confidence: 99%

Pharmacologically relevant drug interactions of Glucagon-like peptide-1 receptor agonists

Maideen¹

2019

JAPLR

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Glucagon-like peptide-1 receptor agonists are incretin mimetics and they help to manage the blood glucose of patients with type 2 diabetes mellitus. The gastric emptying is delayed by the administration of Glucagon-like peptide-1 receptor agonists and hence the absorption of orally administered medications such as Acetaminophen, Digoxin, Warfarin, Oral contraceptive pills, Metformin, Statins, Angiotensin Converting Enzyme Inhibitors and Griseofulvin delayed by their concomitant use. It has been observed that the pharmacokinetics of all these drugs did not get altered by the concurrent administration of Glucagon-like peptide-1 receptor agonists. Moreover, the delay in absorption of interacting drugs could be avoided by taking 1 hour before the administration of Glucagon-like peptide-1 receptor agonists.

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Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs

Abstract: Due to the possible interaction of herbal supplements with sulfonylurea antidiabetics, prescribers and pharmacists are required to be aware of these drug interactions to avoid the possible problems for patients.

Cited by 19 publications

References 120 publications

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Characterization of α-Glucosidase Inhibitors from Psychotria malayana Jack Leaves Extract Using LC-MS-Based Multivariate Data Analysis and In-Silico Molecular Docking

Pharmacologically relevant drug interactions of Glucagon-like peptide-1 receptor agonists

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