Pharmacology and hypnogenic properties of brotizolam in animals.

Kuhn, F J; Böke-Kuhn, K.; Danneberg, P; Lehr, E.; Stockhaus, K

doi:10.1111/j.1365-2125.1983.tb02297.x

Cited by 13 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immobility, for example, may be the result of fear (' freezing') but also of docility, with the animals waiting quietly for their return to the home environment. To differentiate between these motivations and to more clearly determine which measures objectively indicate fear, we treated female dairy calves aged 8-9 months with an anxiolytic (6,26), the benzodiazepine derivative Mederantil® (0.2 mg Brotizolam/ml propylene glycol) in dosage groups of 0.0125 (n=8), 0.05 (n=8), 0.2 (n=8), and 0.8 (n=8) mg/100 kg live weight. Twelve control animals received propylene glycol only.…”

Section: Fear In Cattle (I)mentioning

confidence: 99%

Farm animal welfare research in interaction with society

Blokhuis¹,

Ekkel²,

Korte³

et al. 2000

Veterinary Quarterly

View full text Add to dashboard Cite

SUMMARYOver the last 30 years concern about farm animal welfare has increased and has become a public issue in the Netherlands. Public discussion has stimulated research in this field, financed by both government and industry. Dutch society in general and consumers of animal products in particular, want to see high standards of welfare for production animals. Good animal welfare has gradually gained more impact in the total quality concept of the product. This will encourage scientists to continue to analyse the welfare status of animals and to come up with innovative solutions for the remaining problems. At ID-Lelystad much effort is put into farm animal welfare research. This research includes for example, the development of behavioural tests for quantifying and interpreting fear in cattle, investigations into the effects of dietary iron supply and a lack of roughage on behaviour, immunology, stress physiology, and pathology in veal calves, studies of the ontogeny of tail biting in finishing pigs and feather pecking in laying hens as well as evaluation of the welfare effects of automatic milking in dairy cows. The results of these projects contribute to concrete improvements in animal husbandry and expertise and support policy making and legislation. The animal industry as well as retailers should aim at the further implementation of this knowledge and to specify welfare standards to guarantee consumer acceptance of animal production.

show abstract

Section: Fear In Cattle (I)mentioning

confidence: 99%

Farm animal welfare research in interaction with society

Blokhuis¹,

Ekkel²,

Korte³

et al. 2000

Veterinary Quarterly

View full text Add to dashboard Cite

show abstract

“…The major metabolites are hydroxy derivatives, and these are rapidly conjugated with glucuronic acid and excreted in the urine. Two important examples of this group of drugs are the triazolo-benzodiazepine, triazolam (Eberts et al, 1981) and more recently the triazolo-thienodiazepine, brotizolam (Lendorminm) (Bechtel, 1983;Koch, 1979;Krueger, 1983;Kuhn et al, 1983;Saletu et al, 1981;Velasco et al, 1981). In this study we have compared their effectiveness and tolerance using the 0.25 mg dose in each case.…”

Section: Introductionmentioning

confidence: 99%

Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam.

Goetzke¹,

Findeisen²,

Welbers³

1983

Brit J Clinical Pharma

View full text Add to dashboard Cite

Efficacy of and tolerance to 0.25 mg brotizolam and 0.25 mg triazolam were compared in hospitalised patients (aged 20 to 69 years) with sleep difficulties. Over 6 days there were no differences in efficacy and tolerance. The physicians reported the effectiveness of the drugs as good‐to‐satisfactory in 88.6% with brotizolam and 92.0% with triazolam. The patients reported with both drugs reduced time to fall asleep, less awakenings, increased duration of sleep and improved condition on awakening.

show abstract

Brotizolam Radioimmunoassay: Development, Evaluation, and Application to Human Plasma Samples

Bechtel

Weber

1985

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Pharmacology and hypnogenic properties of brotizolam in animals.

Cited by 13 publications

References 3 publications

Farm animal welfare research in interaction with society

Farm animal welfare research in interaction with society

Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam.

Brotizolam Radioimmunoassay: Development, Evaluation, and Application to Human Plasma Samples

Contact Info

Product

Resources

About