Pharmacology and preclinical pharmacokinetics of peppermint oil

Grigoleit, H.-G.; Grigoleit, P.

doi:10.1016/j.phymed.2004.10.007

Cited by 119 publications

(85 citation statements)

References 15 publications

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“…Researchers presumed that EOS could reduce some other gases except VSCs. Second, peppermint oil contained in EOS caused a masking effect against VSCs [21]. That is why in organoleptic measurement, the masking effect made VSCs unable to be sensed.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Oral Refresher Strip Containing Five Types of Essential Oils on Oral Malodor

Hendraputri¹,

Rahardjo

Soekanto

2017

Asian J Pharm Clin Res

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Objective: The aim of this study was to determine the efficacy of an oral freshener strip containing five types of essential oils on oral malodor. Methods:This study was a clinical trial using cross-over, randomized-double-blind, and placebo-controlled trial design with 15 male participants. The measured parameters were tongue coating, organoleptic score, and volatile sulfur compounds (VSCs) score. Results:After the essential oil strip dissolved in the oral cavity, there was no significant reduction in tongue coating, but there was significant reduction (p<0.05) in the organoleptic score until 60 minutes after dissolved and VSCs until 30 minutes after dissolved. Conclusion:Essential oil strips are more effective than placebo strips in reducing oral malodor.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Oral Refresher Strip Containing Five Types of Essential Oils on Oral Malodor

Hendraputri¹,

Rahardjo

Soekanto

2017

Asian J Pharm Clin Res

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“…Menthol, which is peppermint's main essential oil, has antimicrobial (17) and antiprotozoal (18) functions that manipulate rumen fermentation, and is thought to have the strongest effect in suppressing smooth muscle contraction (35).…”

Section: Discussionmentioning

confidence: 99%

Effects ofMentha longifoliaessential oil on ruminal and abomasal longitudinal smooth muscle in sheep

Jalilzadeh-Amin

Maham

Dalir‐Naghadeh

et al. 2012

Journal of Essential Oil Research

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Mentha longifolia is grown commercially for production of oils and leaves. For centuries, this plant has widely been used traditionally as a folk remedy for treatment of human and ruminant gastrointestinal complaints in the Northwest of Iran. The essential oil of the plant was extracted using hydrodistillation. In the present study a total of 12 constituents, representing 96.6% of the oil were identified by gas chromatography/mass spectrometry (GC/MS). The main compounds were 1,8-cineole (19.8%), pulegone (17.3%), caryophyllene oxide (14.8%) and isomenthone (12.4%). The effects of 0.1 to 1000 g/mL essence of Mentha longofolia (EOML) on ruminal and abomasal smooth muscle of 24 healthy sheep were assessed in vitro. In the isolated ruminal and abomasal preparations, EOML (0.1-100 g/mL) exhibited a weak spasmogenic effect followed by relaxation and complete (p < 0.05) abolition of the spontaneous contraction at the highest dose (1000 g/mL). In contrast rat ileum only showed a dose-dependent relaxation effect, and tissues preincubated with EOML decreased the acetylcholine (ACh) induced contraction. EOML (1000 g/mL) significantly inhibited the effect of ACh suggesting that the effect may be mediated via cholinergic receptors on smooth muscle. These primary data indicated that the plant contained spasmogenic and spasmolitic constituents. Moreover the results showed that the EOML profoundly alters gastrointestinal smooth muscle contraction in a dosedependent and tissue-specific manner. The results suggested that EOML has the potential for development as a prokinetic and relaxant agent that may prevent or alleviate dysfunctions of gastrointestinal motility.

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“…The main metabolite identified was mentholglucuronide. Additional metabolites are mono-or di-hydroxylated menthol derivatives [6].…”

Section: Pharmacological Studiesmentioning

confidence: 99%

Mentha haplocalyx Briq. 薄荷 (Bohe, Mint)

Zhang

Qian

et al. 2015

Dietary Chinese Herbs

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Pharmacology and preclinical pharmacokinetics of peppermint oil

Cited by 119 publications

References 15 publications

Efficacy of Oral Refresher Strip Containing Five Types of Essential Oils on Oral Malodor

Efficacy of Oral Refresher Strip Containing Five Types of Essential Oils on Oral Malodor

Effects ofMentha longifoliaessential oil on ruminal and abomasal longitudinal smooth muscle in sheep

Mentha haplocalyx Briq. 薄荷 (Bohe, Mint)

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