Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action

Pope, Carey; Karanth, Subramanya; Liu, Jing

doi:10.1016/j.etap.2004.12.048

Cited by 275 publications

(170 citation statements)

References 95 publications

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“…It is well known that the P@O bond of OPPs can inhibit acetylcholinesterase, which leads to accumulation of acetylcholine in mammal bodies (Pope et al, 2005). Therefore, if a byproduct generated from OMT degradation retains the P@O bond, it still has an acute toxicity.…”

Section: Toxicity Change Of Omt Solutionmentioning

confidence: 99%

Kinetics and mechanism for omethoate degradation by catalytic ozonation with Fe(III)-loaded activated carbon in water

2013

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Section: Toxicity Change Of Omt Solutionmentioning

confidence: 99%

Kinetics and mechanism for omethoate degradation by catalytic ozonation with Fe(III)-loaded activated carbon in water

2013

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“…Among pesticides, organophosphate pesticides are stable enough to remain in their toxic form for relatively shorter periods of time (Poovala et al, 1998). They act primarily by inhibiting the enzyme acetylcholine esterase at cholinergic junctions of the nervous system (Gallo and Lawryk, 1991) leading to functional changes at the tissue/organism level (Pope et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Application of primary haemocyte culture of Penaeus monodon in the assessment of cytotoxicity and genotoxicity of heavy metals and pesticides

Jose

Puthumana

Mohandas

et al. 2011

Marine Environmental Research

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a b s t r a c tLack of shrimp cell lines has hindered the study of pollutants which adversely affects shrimp health and its export value. In this context a primary haemocyte culture developed from Penaeus monodon was employed for assessing the cytotoxicity and genotoxicity of two heavy metal compounds, cadmium chloride and mercuric chloride and two organophosphate insecticides, malathion and monocrotophos.Using MTT assay 12 h IC 50 values calculated were 31.09 AE 16.27 mM and 5.52 AE 1.16 mM for cadmium chloride and mercuric chloride and 59.94 AE 52.30 mg l À1 and 186.76 AE 77.00 mg l À1 for malathion and monocrotophos respectively. Employing Comet assay, DNA damage inflicted by these pollutants on haemocytes were evaluated and the pollutants induced DNA damage in >60% of the cells. The study suggested that haemocyte culture could be used as a tool for quantifying cytotoxicity and genotoxicity of aquaculture drugs, management chemicals and pollutants.

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“…acetycholine esterase), the observation of interactive or 293 additive effects cannot be extrapolated from one insecticide to another. However, inhibition of acetylcholine 294 esterase by organosphosphates is less reversible and hence longer-lasting than inhibition of acetylcholine esterase 295 by carbamates (Pope et al, 2005). This difference in recovery time may be a potential explanation for the shift in 296 combined effects with cyanobacteria from antagonistic interaction with carbaryl (a carbamates) to additivity with 297 chlorpyrifos (an organophosphate).…”

mentioning

confidence: 99%

“…This difference in recovery time may be a potential explanation for the shift in 296 combined effects with cyanobacteria from antagonistic interaction with carbaryl (a carbamates) to additivity with 297 chlorpyrifos (an organophosphate). Alternatively, choline esterase inhibitors have been shown to target other 298 molecules than the acetylcholine esterase (Pope et al, 2005). Differences in the ability to target other molecules 299 could also be a potential explanation for the differences in interactive effects observed for carbaryl and 300 chlorpyrifos.…”

mentioning

confidence: 99%

Ecotoxicity of binary mixtures of Microcystis aeruginosa and insecticides to Daphnia pulex

Asselman

Janssen

Smagghe

et al. 2014

Environmental Pollution

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15In aquatic ecosystems, mixtures of chemical and natural stressors can occur which may significantly complicate risk 16 assessment approaches. Here, we show that effects of binary combinations of four different insecticides and 17Microcystis aeruginosa, a toxic cyanobacteria, on Daphnia pulex exhibited distinct interaction patterns. 18Combinations with chlorpyrifos and tetradifon caused non-interactive effects, tebufenpyrad caused an antagonistic 19 interaction and fenoyxcarb yielded patterns that depended on the reference model used (i.e. synergistic with 20 independent action, additive with concentration addition). Our results demonstrate that interactive effects cannot 21 be generalised across different insecticides, not even for those targeting the same biological pathway (i.e. 22 tebufenpyrad and tetradifon both target oxidative phosphorylation). Also, the concentration addition reference 23 model provided conservative predictions of effects in all investigated combinations for risk assessment. These 24 predictions could, in absence of a full mechanistic understanding, provide a meaningful solution for managing 25 water quality in systems impacted by both insecticides and cyanobacterial blooms. 26 27Capsule: Interactive effects between insecticides and cyanobacterial stressors cannot be generalized, not even for 28 insecticides with closely related known modes of action. 29 30

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Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action

Cited by 275 publications

References 95 publications

Kinetics and mechanism for omethoate degradation by catalytic ozonation with Fe(III)-loaded activated carbon in water

Kinetics and mechanism for omethoate degradation by catalytic ozonation with Fe(III)-loaded activated carbon in water

Application of primary haemocyte culture of Penaeus monodon in the assessment of cytotoxicity and genotoxicity of heavy metals and pesticides

Ecotoxicity of binary mixtures of Microcystis aeruginosa and insecticides to Daphnia pulex

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