Pharmacology of Casimiroa edulis; III. Relaxant and contractile effects in rat aortic rings

Age-dependent vasorelaxation of Casimiroa edulis and Casimiroa pubescens extracts in rat caudal artery in vitro

“…It was also suggested that the H 1 -receptor-induced relaxation could be partly endothelium-dependent (Baisch et al, 2004). In vitro other authors showed an endothelium-independent inhibition of the vasoconstriction by norepinephrine, 5-hydroxytryptamine and PGF 2␣ (Magos et al, 1995). However, these authors also observed vasoconstriction induced by Casimiroa edulis (0.01-1 mg/ml), through activation of ␣ 1 -adrenergic receptors.…”

Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms

“…The hypotensive action of Casimiroa edulis extracts has been related to different types of alkaloids such as N,N-dimethylhistamine and casimiroedine (Randolph Major, 1958;Lozoya-Legorreta et al, 1978;Magos et al, 1999); recently, others authors have evidenced new quinolone alkaloids with hypotensive activity (Awaad et al, 2007). Magos et al (1995) have studied vascular effects of pretreatment in vitro with an aqueous extract of Casimiroa edulis (1 mg/ml) showing inhibition of vasoconstriction by norepinephrine, 5-hydroxytryptamine and PGF 2␣ , but not by KCl, independently from endothelium presence. These authors also observed vasoconstriction induced by Casimiroa edulis (0.01-1 mg/ml), through activation of ␣ 1 -adrenergic receptors (Magos et al, 1995).…”

“…Magos et al (1995) have studied vascular effects of pretreatment in vitro with an aqueous extract of Casimiroa edulis (1 mg/ml) showing inhibition of vasoconstriction by norepinephrine, 5-hydroxytryptamine and PGF 2␣ , but not by KCl, independently from endothelium presence. These authors also observed vasoconstriction induced by Casimiroa edulis (0.01-1 mg/ml), through activation of ␣ 1 -adrenergic receptors (Magos et al, 1995).…”

Central nervous system activity of the hydroalcoholic extract of Casimiroa edulis in rats and mice

“…The hypotensive properties of an aqueous extract of seeds from Casimiroa edulis were also demonstrated in anesthetized rats and dogs , being attributed to the activation of H 1 and H 3 receptors . Magos et al (1995) reported that the aqueous extract from seeds of this species also elicited contractions in rat aortic rings, probably mediated by the vascular endothelium and ␣-adrenergic receptors. Likewise, these authors reported a relaxant effect in this organ, which was not mediated by endothelial relaxing mechanisms, nor by calcium channel or smooth muscle receptors.…”