Pharmacology of DMSO

Jacob, Stanley W.; Herschler, Robert

doi:10.1016/0011-2240(86)90014-3

Cited by 249 publications

(131 citation statements)

References 63 publications

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“…DMSO was chosen because it has low toxicity, it has been found to have beneficial effects in a wide range ofdisease models, and it possesses chemical properties which allow it to readily penetrate cell membranes (41,42 The effect of 1% DMSO on the time course of IL-8 production was also evaluated (Fig. 1 B).…”

Section: Resultsmentioning

confidence: 99%

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

DeForge¹,

Fantone²,

Kenney³

et al. 1992

J. Clin. Invest.

221

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The hydroxyl radical (OH') scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood. At a concentration of 1% (vol/ vol), DMSO blocked IL-8 release by 90% in the presence of 1 ,ug/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1fi ). DMSO was found to directly inhibit IL-8 expression at the level of transcription. Furthermore, this effect was not LPS-specific, in that IL-8 production was reduced by DMSO to a similar extent upon stimulation of blood with phytohemagglutinin, aggregated immune complexes, TNF, or IL-1ft.Other oxygen radical scavengers that have been shown to inhibit OH-dependent reactions (dimethyl thiourea, thiourea, mannitol, and ethanol) also inhibited IL-8 production. Conversely, addition of H202 caused a dose-dependent stimulation of IL-8 release. These results provide evidence that reactive oxygen metabolites play an important role in the regulation of IL-8 production and suggest that reduction of IL-8 release may contribute to the beneficial effects ofantioxidants in experimental models of inflammation and ischemia/reperfusion injury.

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Section: Resultsmentioning

confidence: 99%

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

DeForge¹,

Fantone²,

Kenney³

et al. 1992

J. Clin. Invest.

221

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“…DMSO has a wide spectrum of biological activities, including high penetrating activity and significant vasoactive effects on blood vessels [138,139] . It is used for local treatment of trauma, arthrosis, and rheumatoid a r t h r i t i s [ 1 4 0 , 1 4 1 ] .…”

Section: Pharmacological Effects Of Dimethyl Sulfoxide (Dmso)mentioning

confidence: 99%

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Galanzha¹

2007

WJG

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Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo . Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell's functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo-and radio-sensitivity tests, and drug screening, are also discussed. TOPIC HIGHLIGHT

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“…DMSO in DESS crosses tissue membranes and changes the structure of membrane-bound proteins (Jacob, 1971;Seutin et al, 1991), enhancing the transport of certain materials into cells and tissue spaces, particularly molecules of lower molecular weight. Investigators using DESS should, therefore, avoid direct contact with solutions containing preserved parasites because the membrane transport properties of DMSO may increase exposure to small immunogenic molecules such as parasite haptens.…”

mentioning

confidence: 99%

Structural Restoration of Nematodes and Acanthocephalans Fixed in High Percentage Alcohol Using Dess Solution and Rehydration

Naem

Pagan

Nadler

2010

Journal of Parasitology

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Pharmacology of DMSO

Cited by 249 publications

References 63 publications

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Structural Restoration of Nematodes and Acanthocephalans Fixed in High Percentage Alcohol Using Dess Solution and Rehydration

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