Pharmacology of Insect Juvenile Hormones

Sláma, Karel

doi:10.1016/b978-0-08-030812-8.50014-9

Cited by 17 publications

(23 citation statements)

References 126 publications

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“…These findings have important physiological implications with respect to growth and morphological changes induced by the same hormone in different target tissues. They show that one and the same chemical structure of a hormone, such as JH, can cause a plethora of completely different biochemical changes in different, genetically programmed target tissues or cells (Sláma, 1985). The results obtained with the ovary-ectomised females indicate that the simultaneously running developmental functions (ovarian growth and secretory functions of AG) synchronised under normal conditions by JH, can proceed well without direct dependence on each other.…”

Section: Discussionmentioning

confidence: 93%

Juvenile hormone–stimulated synthesis of acyl‐glycerols and vitamin E in female accessory sexual glands of the fire bug, Pyrrhocoris apterus L.

Jedlička¹,

Cvačka²,

Sláma³

2009

Arch Insect Biochem Physiol

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Secretory cells of the female accessory sexual glands (AG) of P. apterus grow and produce yellow oily exocrine secretion in response to stimulation by endogenous juvenile hormone (JH) or exogenous treatments by JH analogues. The secretion determines the property of future egg shells by coating the chorion surface of the oocytes that are passing individually through the common uterus during oviposition. Diapausing females with a physiologically inhibited endocrine system or females with artificially removed hormonal sources show inactive ovaries and empty AG without the secretory products. Ovary-ectomised females with the intact neuroendocrine system develop hypertrophic AG loaded with the oily secretion. This shows that there is no direct dependence between formation of the oily secretion in AG and ovarian growth. Chemical analysis of the secretory products revealed the presence of acetylated glycerols, with the most abundant stearoyl-diacetyl-glycerol, stearoyl-acetyl-propionyl-glycerol, and the corresponding derivatives of arachidonic acid. In addition to this, the JH-activated secretory cells of AG also produced gamma- and delta-tocopherols. The possible antioxidant or antimutagenic action of these vitamin E compounds in insect reproduction has been emphasized.

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Section: Discussionmentioning

confidence: 93%

Juvenile hormone–stimulated synthesis of acyl‐glycerols and vitamin E in female accessory sexual glands of the fire bug, Pyrrhocoris apterus L.

Jedlička¹,

Cvačka²,

Sláma³

2009

Arch Insect Biochem Physiol

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“…Although we did not find typical a dose-response curve for JH and its analogues in the induction of mitochon-drial swelling, there are differences between individual JHAs in the threshold concentration which may reflect a difference in their biological activity normally seen in the morphogenetic tests. A typical dose-dependent response is characteristic of hormone effects mediated by the receptors (Sláma 1985), whereas here, we deal with an all-or-none effect. The particular concentration of JH or JHA at which CO activity becomes upregulated and the swelling effect becomes suddenly visible can be related to the opening of ion channels in the mitochondrial membrane.…”

Section: Discussionmentioning

confidence: 99%

Swelling of mitochondria induced by juvenile hormone in larval salivary glands ofDrosophila melanogaster

Farkas

Sutáková²

2001

Biochem. Cell Biol.

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Treatment of Drosophila larval salivary glands with juvenile hormone or its analogues leads to ultrastructural changes of mitochondria that mimic those seen after application of uncouplers of oxidative phosphorylation. This alteration of mitochondria, also known as swelling, is manifested in strong dilatation of their intercristae space. The mitochondrial response of salivary glands to juvenile hormone is restricted to collum cells that are known to be ultrastructurally and functionally different from transitional and corpus cells and may reflect their specialization in energy metabolism and water/ion balance. Morphological change of mitochondria and about a fivefold increase in cytochrome c oxidase activity in response to juvenile hormone appear to be a consequence of uncoupling of oxidative phosphorylation. We have noticed no significant difference of the responses in Methoprene, the juvenile hormone resistant mutant, suggesting that this action of juvenile hormone may be mediated via a mechanism different from that using nuclear transcription factors. The "uncoupling" effect is caused also by juvenile hormone analogues which are considered inactive in producing morphogenetic effects in Drosophila. Mitochondrial response is independent of transcription and translation, as revealed by the use of RNA and protein synthesis inhibitors. Given these data together, we reasoned that the protonophoric/uncoupling effect of juvenile hormone is a cell type specific nongenomic response to this lipophilic ligand and contrasts with widely accepted notions about nuclear action of juvenile hormone.

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“…Biological activity of applied juvenoids is conditioned by the size and shape of their molecules and also their stability in insect body (SLAMA, 1985). The activity of methoprene, compared to hydroprene is higher, probably due to its carbisopropoxy group, which is more resistant to enzymatic degradation (TERRIERE and Yu, 1973;WHITE, 1972).…”

Section: : the Adultoid At Ecdysial Death (Grade 4 ) 6: The Supernmentioning

confidence: 99%

Control of Cacopsylla (Psylla) pyri (L.) (Stenorhyncha, Psyllidae) by juvenile hormone analogues

Baldassari

Baronio

Němec

et al. 1997

J Applied Entomology

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Juvenoids could be a useful tool for the control of psyllids. The 12 new juvenoids synthetized at the Institute of Organic Chemistry and Biochemistry in Prague were tested by dipping the feeding plants in the juvenoid solution and by indirect contact application on Cacopsylla (Psylla) pyri (L.). The tested compounds were mostly less active than the commercial juvenoid, methoprene. However, even the low doses of active juvenoids which evoked only small malformations on wings and external genitalia of the treated psyllids disabled them from flying and also from copulation. The most sensitive period for juvenoids in psyllids comprises the first 4 days of the last larval instar. Aside from this period, juvenoids failed to evoke any malformation. The investigated juvenoids were also tested on the main predator of psyllids, the pirate bug, Anthocoris nemoralis (Fabr.), using the indirect topical application. It was found that the sensitive period of these bugs to the tested juvenoids is restricted to the first 24 h of the last larval instar. Hence, the pirate bug revealed very low sensitivity to the tested juvenoids.

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Pharmacology of Insect Juvenile Hormones

Cited by 17 publications

References 126 publications

Juvenile hormone–stimulated synthesis of acyl‐glycerols and vitamin E in female accessory sexual glands of the fire bug, Pyrrhocoris apterus L.

Juvenile hormone–stimulated synthesis of acyl‐glycerols and vitamin E in female accessory sexual glands of the fire bug, Pyrrhocoris apterus L.

Swelling of mitochondria induced by juvenile hormone in larval salivary glands ofDrosophila melanogaster

Control of Cacopsylla (Psylla) pyri (L.) (Stenorhyncha, Psyllidae) by juvenile hormone analogues

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