Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals

Carlini, E. A.; Contar, Juida de Deus Palma; Silva-Filho, Armando Ramos; Silveira-Filho, Nylson G. Da; Frochtengarten, Mario Luiz; Bueno, Orlando Francisco Amodeo

doi:10.1016/0378-8741(86)90072-3

Cited by 163 publications

(89 citation statements)

References 19 publications

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“…route various doses of the extracts P and M. Thirty minutes later, 0.35 mL of a suspension of 10% activated charcoal (Merck) prepared in a 5% solution of gum arabic, was introduced by gavage into the stomach of each animal. Fifteen minutes later, the animals were sacrificed by cervical dislocation, and the small intestine was removed; the total length was measured along with the distance up to the point of dislocation of the charcoal, where transit was expressed a percentage of distance (Turner, 1965;Carlini et al 1986). …”

Section: Measure Of Intestinal Transit In Micementioning

confidence: 99%

Antiulcer effect of the pepper trees Schinus terebinthifolius Raddi (aroeira-da-praia) and Myracrodruon urundeuva Allemão, Anacardiaceae (aroeira-do-sertão)

Carlini¹,

Duarte-Almeida²,

Rodrigues³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Ação antiúlcera das aroeiras Schinus terebinthifolius Raddi (aroeira-dapraia) e Myracrodruon urundeuva Allemão, Anacardiaceae (aroeira-do-sertão)". Foram avaliados, em ratos e camundongos, os efeitos antiúlcera de duas plantas usadas popularmente no Brasil para o tratamento de "males gástricos": a Schinus terebinthifolius Raddi (aroeira-dapraia) e a Myracrodruon urundeuva Allemão (aroeira-do-sertão). Os decoctos de ambas as plantas apresentaram um marcante efeito protetor da mucosa gástrica contra as ulcerações induzidas por estresse de imobilização em baixa temperatura em ratos. Ambas as plantas apresentaram, ainda: elevação do pH, do volume do conteúdo gástrico, redução das hemorragias gástricas e do trânsito intestinal em camundongos, mesmo em doses tão reduzidas quanto 3,4 mg/kg (1/4 da dose utilizada pelo homem).Unitermos: Schinus terebenthifolius, Myracrodruon urundeuva, pH, trânsito intestinal; úlcera gástrica; hemorragia gástrica. ABSTRACT: Schinus terebinthifoliusRaddi and the Myracrodruon urundeuva Allemão were evaluated in rats and mice for antiulcer effects, as these two plants are widely used in Brazil for gastric ulcer treatment. Extracts of the plants showed a marked protective effect against gastric ulcerations induced by immobilization stress at low temperature in rats. They also showed an increase in the pH and volume of the gastric contents, and reduction in gastric hemorrhage in rats, and decrease in intestinal transit in mice, even at the low doses of 3.4 mg/kg (1/4 of the dose used by humans).

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Section: Measure Of Intestinal Transit In Micementioning

confidence: 99%

Antiulcer effect of the pepper trees Schinus terebinthifolius Raddi (aroeira-da-praia) and Myracrodruon urundeuva Allemão, Anacardiaceae (aroeira-do-sertão)

Carlini¹,

Duarte-Almeida²,

Rodrigues³

et al. 2010

Rev. bras. farmacogn.

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“…with sodium pentobarbital (50 mg/kg). Latency for the loss of the righting reflex and its total duration was registered for three consecutive hours [34].…”

Section: Potentiation Of Barbiturate-induced Loss Of Righting Reflexmentioning

confidence: 99%

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

Coleta

Campos

Cotrim

et al. 2008

Behavioural Brain Research

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Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABA A receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Luteolin (3 ,4 ,5,7-tetrahydroxyflavone) is a widespread flavonoid aglycon that was reported as devoid of specific affinity for benzodiazepine receptor (BDZ-R) binding site, but its psychopharmacological activity is presently unknown. Considering (1) the close structural similarity with other active flavones, (2) the activity of some of its glycosilated derivatives and (3) the complexity of flavonoid effects in the central nervous system, luteolin was submitted to a battery of tests designed to evaluate its possible activity upon the CNS and its ability to interact with the BDZ-receptor binding sites was also analysed.Luteolin apparently has CNS activity with anxiolytic-like effects despite the low affinity for the BDZ-R shown in vitro. Our findings suggest a possible interaction with other neurotransmitter systems but we cannot rule out the possibility that luteolin's metabolites might show a higher affinity for the BDZ-R in vivo, thus eliciting the evident anxiolytic-like effects through a GABAergic mechanism.

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“…The number of central square entries and the duration of time spent in the central square are measures of exploratory behaviour and anxiety. A high frequency/duration of these behaviors' indicates high exploratory behaviour and low anxiety levels [12].…”

Section: Oftmentioning

confidence: 99%

A Review Study on the Traditional Plants has Potential Antidepressant Property

Rahman¹

2017

MOJCSR

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DiscussionThis review includes detailed description of antidepressant activity of 21 medicinal plants whose roots, leaves, fruits extracts were used to evaluate the activity from various research articles.The tests employed for antidepressant activity includes HBT, FST, TST, OFT, EPMT, and MACT using rotarod and THB. These tests are employed with slight modification from original method, keeping basic concept same. HBTExploratory behaviour of rodents such as mice is evaluated using hole board test. The floor of the apparatus has regularly arranged holes. The animal is placed in the arena. Both frequency and duration of spontaneous elicited hole-poking behavior are then measured during a short period of time. This test also provides a simple method for assessing anxious response of a rodent to an unfamiliar environment. The use of the hole-board in this perspective relies on the hypothesis that the behavior of animals exposed to a novel situation results from competition AbstractDepression refers to a state of low mood and aversion to activity characterized by depressed mood, loss of interest, reduced energy and concentration. The reasons for the disease include stimulation of MAO-A, inhibition of NA and 5-HT. Symptoms include the diminished interest of pleasure, feelings of worthlessness or inappropriate guilt, a decrease in appetite and libido, insomnia, and recurrent thoughts of death or suicide. There are plenty of synthetic drugs used to treat depression but not enough blissful for patients, moreover, these synthetic drugs have potential side effects. After decades of serious obsession with the modern medicinal system, people have started looking at the ancient healing systems like Ayurveda, Siddha, and Unani. Many scientists are researching plant material for treating this disorder and there are lots of publications on it. But this is not sufficient for treating depression; further outcome should come into light that's the purpose of our review.

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Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals

Cited by 163 publications

References 19 publications

Antiulcer effect of the pepper trees Schinus terebinthifolius Raddi (aroeira-da-praia) and Myracrodruon urundeuva Allemão, Anacardiaceae (aroeira-do-sertão)

Antiulcer effect of the pepper trees Schinus terebinthifolius Raddi (aroeira-da-praia) and Myracrodruon urundeuva Allemão, Anacardiaceae (aroeira-do-sertão)

Assessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity

A Review Study on the Traditional Plants has Potential Antidepressant Property

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