Pharmacology of Macroalgae Alkaloids

Kaleagasioglu, Ferda; Güven, K. C.; Sezik, Ekrem; Erduğan, Hüseyin; Çoban, Burak

doi:10.1007/978-3-642-22144-6_3

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…The explorations of these organisms for pharmaceutical purposes have revealed important chemical prototypes for the discovery of new agents, which has also allowed to stimulate the synthesis of compounds with biomedical applications (Radhika et al, 2012;Offret et al, 2016). In China and Japan, marine macroalgae have been used as drug preparations, especially for the treatment of Basedow's disease, Acquired Immunodeficiency Syndrome (AIDS), rheumatoid arthritis, hyperthyroidism and cancer, as a vermifuge, and as hypocholesterolemic and hypoglycemic agents (Kaleağasıoğlu et al, 2013;Astorga-España & Mansilla, 2014;Sakulpong et al, 2015;Anand et al, 2016;Paiva et al, 2016). Moreover, the incorporation of algae Martínez Y, Ayala L, Hurtado C, Más D, Rodríguez R eRBCA-2019eRBCA- -1015 in other products improves or increases the nutritional value of foods; because these are rich in amino acids, vitamins, fatty acids, polyphenols, phytosterols, minerals, dietary fiber and antioxidant compounds (Farvinand & Jacobsen, 2013;Sakulpong et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation with Red Algae Powder (Chondrus crispus) on Growth Performance, Carcass Traits, Lymphoid Organ Weights and Intestinal pH in Broilers

Martínez¹,

Ayala²,

Hurtado

et al. 2019

Braz. J. Poult. Sci.

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The aim of this study was to determine the effects of dietary supplementation with red algae powder (Chondrus crispus) on the growth performance, carcass traits, lymphoid organ weights and intestinal pH y in broiler chickens. A total of 300 1-day-old B34 line male broiler chickens were randomly allotted to three treatments, four replicates per treatment and 25 birds per replicate. The experimental treatments consisted of a basal diet (T0) and dietary supplementation of 0.30 (T2) and 0.40% (T2) red algae powder. Body weight at 1, 21 and 32 days did not show significant differences (p>0.05) among treatments. At 21 days, T1decreased (p<0.05) the feed intake and feed conversion ratio. However, from 22 to up to 32 days, these productive indicators increased (p<0.05) with the use of the natural product (red algae powder) tested. Meanwhile, T1 improved (p<0.05) the carcass and breast yields and decreased the abdominal fat yield, and T2increased (p<0.05) the relative weights of the bursa of Fabricius and the thymus. The relative weight of the spleen, the other edible parts and the intestinal pH did not change (p>0.05) with the red algae supplementation. The dietary supplementation of 0.30% red algae improved the growth performance (at 21-day-old) and some edible parts; also, the dietary supplementation of 0.40% increased the relative weight of the lymphoid organs, without changing the intestinal pH of broilers.

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Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation with Red Algae Powder (Chondrus crispus) on Growth Performance, Carcass Traits, Lymphoid Organ Weights and Intestinal pH in Broilers

Martínez¹,

Ayala²,

Hurtado

et al. 2019

Braz. J. Poult. Sci.

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“…Most of the alkaloids of the indole group are concentrated in Rhodophyta [ 70 ]. Some of these alkaloids exhibit numerous pharmacological effects like neuromodulation, neurotransmission, growth regulation, cytotoxicity, angiogenesis, antioxidant, as well as antibacterial, antifungal and larvicidal activities [ 71 ].…”

Section: Neuroprotective Compounds From Macroalgaementioning

confidence: 99%

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

2014

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Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases.

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