Pharmacology of the Parietal Cell

Sachs, George; Maton, Paul N.; Wallmark, Björn

doi:10.1007/978-3-642-75858-4_1

Cited by 3 publications

(1 citation statement)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyperchlorhydria is a stomach situation characterized by uncontrolled hypersecretion of hydrochloric acid from the parietal cells of gastric mucosa through the proton pump 26 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

The present study aimed to determine secondary metabolites, invitro antioxidant, and antiulcer activities using various solvent-based Muehlenbeckia platyclada extracts. Solvents based phylloclade extraction was used to determine various secondary metabolites such as phenols, flavonoids, terpenoids and tannins and to assess in-vitro antioxidant activities such as DPPH, ABTS .+ , superoxide, hydrogen peroxide, nitric oxide, FRAP, Phosphomolybdenum, metal chelating and reducing power activities. Further, invitro antiulcer activities such as α-chymotrypsin enzyme, urease enzyme inhibitory activity, H + K + ATPase activity and acid neutralization capacity (ANC) were performed, and the resultant was analyzed using response surface methodology (RSM) to develop an adequate functional relationship between a response of interest (ME) with independent variables (Time, HCL consumed and NaOH consumed). A correlation coefficient was made between secondary metabolites and in-vitro antiulcer activities. Methanolic extract (ME) showed higher levels of secondary metabolites, in-vitro antioxidant activities and was subsequently selected to evaluate its antiulcer potential. A significant inhibition for alpha chymotrypsin (88.84%), urease (68.52%), and H + K + ATPase (91.75%) was compared with respective standards. RSM results of ME for ANC indicated that 10 min, 22.66 mL HCl and 30.7 mL NaOH are adequate to get maximum ANC i.e. 46 mEq/ml. A significant correlation (P<0.05) was found between phenol and ACE (R 2 =0.948), between phenol and HKA (R 2 =0.941) and phenol and UE (R 2 =0.952). These results suggest that ME of M. platyclada possesses potential antiulcer activities due to higher levels of secondary metabolites and in-vitro antioxidant activities.

show abstract

“…Hyperchlorhydria is a stomach situation characterized by uncontrolled hypersecretion of hydrochloric acid from the parietal cells of gastric mucosa through the proton pump 26 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

show abstract

Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: effect on H+-K+-ATPase, oxidative damage and apoptosis

Chattopadhyay

Nandi

Chatterjee

et al. 2004

Inflammopharmacology

View full text Add to dashboard Cite

The mechanism of the antiulcer effect of Neem leaf aqueous extract to block gastric lesions in rat has been studied with emphasis on acid secretion, oxidative damage and apoptosis. The extract dose-dependently inhibits gastric lesions induced by restraint-cold stress, indomethacin and ethanol. In stress ulcer model, it is more effective than ranitidine but less effective than omeprazole. It also dose-dependently blocks pylorus ligation and mercaptomethylimidazole-induced acid secretion. In the pylorus-ligation model, it is less effective than omeprazole but as effective as ranitidine. It inhibits H+-K+-ATPase activity in vitro in concentration-dependent manner to inhibit acid secretion. Oxidative membrane damage by hydroxyl radical (*OH) as measured by lipid peroxidation in stress ulcer is significantly blocked by leaf extract. Stress-induced apoptotic DNA fragmentation is also protected. The extract also prevents *OH-mediated mucosal DNA damage in vitro by scavenging the *OH. Neem leaf extract, thus, offers antiulcer activity by blocking acid secretion through inhibition of H+-K+-ATPase and by preventing oxidative damage and apoptosis.

show abstract

In vitro H⁺-K⁺ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

Yadav¹,

Ganeshpurkar²,

Rai³

2012

Phcog Res

View full text Add to dashboard Cite

Objective:This study was undertaken to study in vitro H+ -K+ ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.Materials and Mathods:Total phenolic and flavonoid contents from extract was quantified and H+ -K+ ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract.Results:Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard.Conclusions:These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.

show abstract

Pharmacology of the Parietal Cell

Cited by 3 publications

References 82 publications

Untitled

Untitled

Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: effect on H+-K+-ATPase, oxidative damage and apoptosis

In vitro H⁺-K⁺ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

Contact Info

Product

Resources

About

Pharmacology of the Parietal Cell

Cited by 3 publications

References 82 publications

Untitled

Untitled

Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: effect on H+-K+-ATPase, oxidative damage and apoptosis

In vitro H+-K+ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

Contact Info

Product

Resources

About

In vitro H⁺-K⁺ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.