Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services

Bjånes, Tormod Karlsen; Hjertø, Espen Mjåset; Lønne, Lars; Aronsen, Lena; Berg, Jon Andsnes; Bergan, Stein; Berg-Hansen, Grim Otto; Bernard, Jean‐Paul; Burns, Margrete Larsen; Fosen, Jan Toralf; Frost, Joachim; Hilberg, Thor; Krabseth, Hege-Merete; Kvan, Elena; Narum, Sigrid; Westin, Andreas Austgulen

doi:10.1016/j.clinthera.2015.10.015

Cited by 5 publications

(4 citation statements)

References 2 publications

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“…The Norwegian Association of Clinical Pharmacology launched in February 2015 a web-portal for all pharmacologic and toxicologic analyses that are available in Norway (The Pharmacology Portal). 8 One of the goals is the nationwide harmonization of reference ranges used by the laboratories represented. A working group was established with the task to update and harmonize reference ranges for AEDs.…”

Section: Introductionmentioning

confidence: 99%

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reimers¹,

Berg²,

Burns³

et al. 2018

DDDT

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Background and objectiveLaboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns or inappropriate dose changes, which in turn may affect therapeutic effect, drug safety or treatment adherence. Therefore, the Norwegian Association of Clinical Pharmacology wished to update and harmonize the reference ranges for AEDs and establish national guidelines for Norway.MethodsA working group collected information on the reference ranges used by Norwegian laboratories for all commonly used AEDs. These reference ranges were compared to recent recommendations by the International League Against Epilepsy, current literature, applicable clinical studies, reference ranges used by leading Northern European epilepsy centers outside of Norway, and routine data derived from Norwegian laboratory databases.ResultsReference ranges varied between laboratories for four of 23 available AEDs (lamotrigine, valproate, eslicarbazepine and oxcarbazepine). For four AEDs (brivaracetam, perampanel, stiripentol and sulthiame), reference ranges had not previously been established. In total, 13 reference ranges were either harmonized, updated or newly established. No changes were applied to the remaining 10 AEDs.ConclusionUpdated and harmonized reference ranges are now available for 22 of the 23 AEDs available in Norway. The exception is vigabatrin (reference range not applicable). Revision of reference ranges is an important part of pharmacovigilance of AEDs and must be a continuous process based on current literature and clinical experience.

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Section: Introductionmentioning

confidence: 99%

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reimers¹,

Berg²,

Burns³

et al. 2018

DDDT

Self Cite

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“…The possibility to detect consequences of an interaction is important as it relates potential risk of adverse effects to individual patients. Notably, all four databases recommended monitoring of the interactions associated with consensus, and monitoring of psychotropics are increasingly available through therapeutic drug monitoring (TDM) services . There was a surprising lack of consensus with regard to contraindicated interactions, even when older psychotropics were involved.…”

Section: Discussionmentioning

confidence: 99%

Analysis of consensus among drug interaction databases with regard to combinations of psychotropics

Schjøtt

Schjøtt²,

Aßmus

2019

Basic Clin Pharma Tox

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Drug interaction databases are integrated with dispensing software and computerised clinical decision support systems in health care and are important tools in medication reviews. The databases provide alerts about interaction risks for health care professionals. 1-3 In the absence of standardisation, there is great variation across healthcare organisations and health information technology vendors on how alerts are presented to clinicians. 4,5 It is reported that low clinical relevance alerts have contributed to considerable frustration and dissatisfaction among healthcare professionals. 6 Furthermore, reported override rates for alerts among clinicians are consistently high. 7-9 Lack of concordance with regard to classification of interactions has been documented. 1-5 Various types of data have been used to compare databases including interactions retrieved from a high-priority list, 4 drugs from a specific

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“…Norsk forening for klinisk farmakologi lanserte i februar 2015 Farmakologiportalen som en felles nasjonal nettportal for farmakologiske og toksikologiske analyser (6,7). Som en naturlig konsekvens av dette er det ønskelig at laboratoriene som er representert i portalen bruker de samme referanseområdene.…”

Section: Oppdaterte Felles Referanseområder I Norgeunclassified

Felles referanseområder for antiepileptika

Reimers¹,

Berg²,

Burns³

et al. 2017

Tidsskriftet

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Arne Reimers (f. 1965) er dr.philos., spesialist i klinisk farmakologi og overlege ved Avdeling for klinisk farmakologi, St. Olavs hospital, og førsteamanuensis ved Institutt for laboratoriemedisin, barne-og kvinnesykdommer, Norges teknisk-naturvitenskapelige universitet. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. JON ANDSNES BERG Jon Andsnes Berg (f. 1978) er spesialist i klinisk farmakologi og overlege ved Seksjon for klinisk farmakologi ved Laboratorium for klinisk biokjemi, Haukeland universitetssykehus. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. MARGRETE LARSEN BURNS Margrete Larsen Burns (f. 1980) er spesialist i klinisk farmakologi og overlege/seksjonsleder ved Seksjon klinisk farmakologi, SSE, Avdeling for farmakologi, Oslo universitetssykehus. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. CECILIE JOHANNESSEN LANDMARK Cecilie Johannessen Landmark (f. 1971) er cand.pharm., ph.d., medisinsk rådgiver ved Spesialsykehuset for epilepsi og Avdeling for farmakologi, Oslo universitetssykehus, og førsteamanuensis ved Program for farmasi, Fakultet for helsefag, Høgskolen i Oslo og Akershus. Forfatter har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.

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Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services

Cited by 5 publications

References 2 publications

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

Analysis of consensus among drug interaction databases with regard to combinations of psychotropics

Felles referanseområder for antiepileptika

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