Journal of Enzyme Inhibition and Medicinal Chemistry
 2004
DOI: 10.1080/14756360400004540
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Pharmacomodulation of a Sulfamide 5-HT6 Receptor Ligand

Jacques Renault
1
,
Aurélie Bernard
2
,
Solenn Brajeul
3
et al.

Abstract: A series of N-omega-aminoalkyl- or N-omega-amidinoalkyl-2,4,6-triisopropyl benzenesulfonamides has been synthesized and their respective affinity indices on 5-HT6 receptor determined. This evaluation clearly showed that the compounds possessing an arylpiperazine moiety or an amidine function exhibited good affinity for the model.

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