Pharmaconutrigenetics: The Impact of Genetics on Nutrient–Drug Interactions

Evaluation of the Nurses' Knowledge Levels of Food-Drug Interaction and Some Other Influencing Factors: A Cross-Sectional Study

“…This variation appears to be an important factor that should be combined with variants important in nutritional and pharmacological interventions and should be taken into account in the drug prescription or administration process. 5 In our study, the first two interventions most frequently used by nurses to prevent FDI were not putting drug hours at the same time with the foods that could interact, and observing the patient's response to the drug. Similarly, Oğuz et al stated that 66.7% of the nurses questioned both food-drug and drug-drug interactions before drug administration, and only 42% of the nurses reported side effects that developed in the patient after drug administration.…”

“…3,4 At the intersection point where genetic variation shapes the individual responses to combination of food and drug, pharmacogenetics takes place. 5 The optimal drug concentration range, that is, the therapeutic range that, allows drugs to be effective while avoiding side effects, maybe narrow for some pharmacological agents, making the dosing of the pharmacological agent very precise. 5 Due to physiological changes such as partial dysfunction in kidneys, hepatic blood flow, liver function, lean body mass, or increase in body fat mass and volume of distribution, especially elderly people who take more than one drug, use complementary and alternative therapies, are at risk in terms of FDI.…”

“…5 The optimal drug concentration range, that is, the therapeutic range that, allows drugs to be effective while avoiding side effects, maybe narrow for some pharmacological agents, making the dosing of the pharmacological agent very precise. 5 Due to physiological changes such as partial dysfunction in kidneys, hepatic blood flow, liver function, lean body mass, or increase in body fat mass and volume of distribution, especially elderly people who take more than one drug, use complementary and alternative therapies, are at risk in terms of FDI. 6,7 FDI negatively affects the treatment of patients by increasing the costs of pharmacotherapy and prolonging the duration of hospitalization, and may cause the loss of the expected effect in the treatment (loss of therapeutic efficacy) or the emergence of toxic effects and unwanted adverse effects of drugs.…”

“…11 In the future, it is stated that to achieve better results in the prevention and treatment of diseases, the focus will be on individualized therapies by adapting nutritional and pharmacological interventions to the treatments in a coordinated manner. 5 It is seen that courses such as pharmacology, rational drug use, and drug use in special cases are involved in the curriculum of various stages of nursing education (secondary education and undergraduate education). Besides, special courses on FDI are also included within the scope of master and doctoral programs in nursing.…”

The Use of Complementary and Alternative Treatment in Patients with Asthma and Assessment of Affective Variables: A Cross-Sectional Research

“…7 Gelecekte, hastalıkların önlenmesinde ve tedavide daha iyi sonuçlara ulaşabilmek için beslenme ve farmakolojik müdahalelerin koordineli bir şekilde tedavilere uyarlanması ile bireyselleştirilmiş tedavilere odaklanılacağı ifade edilmektedir. 10 Hemşireler, ilaç etkileşimlerinin istenmeyen etkilerinden kaçınmak için önleyici faktörlerin %80'ini gerçekleştirebilmektedir. 11 Bu kapsamda, besin-ilaç etkileşimlerini içeren advers ilaç reaksiyonlarının önlenmesinde, hasta güvenliğinin sağlanmasında, morbidite ve mortalitenin azaltılmasında hemşirelerin farmakolojik bilgi düzeyleri ve potansiyel besin-ilaç etkileşimleri hakkındaki farkındalıkları önemli bir role sahiptir.…”