Pharmaconutrition

Barros, Karina V.; Cassulino, Ana Paula; Schalch, Lívia; Munhoz, Eduardo Della Valle; Manetta, José Antônio; Calder, Philip C.; Silveira, Vera Lúcia Flor

doi:10.1177/0148607113480183

Cited by 20 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, changes in serum prealbumin were positively correlated with changes in PBMC IL-12, one of the Th1 cytokines, to increase cellular immunity [ 31 ]. These results partly support previous findings that nutrition therapy in critically ill patients plays an important role in assisting recovery and improving outcomes [ 32 , 33 , 34 , 35 , 36 ]. In spite of the small sample size of 22 critically ill patients, this randomized double-blind placebo-controlled study clearly showed beneficial effects following a combination of β-glucan (250 mg/L) and IMHP [high-protein (24% of total calorie from protein) enteral nutrition of immune-modulating nutrients (e.g., ω-3 fatty acids and antioxidants)] on NK cell activity, a marker of immune competence, without significant changes in serum and PBMC levels of IFN-γ, TNF-α, IL-6, and IL-1β.…”

Section: Discussionsupporting

confidence: 90%

Effect of Immune-Enhancing Enteral Nutrition Enriched with or without Beta-Glucan on Immunomodulation in Critically Ill Patients

et al. 2016

View full text Add to dashboard Cite

We investigated whether high-protein enteral nutrition with immune-modulating nutrients (IMHP) enriched with β-glucan stimulates immune function in critically ill patients. In a randomized double-blind placebo-controlled study, 30 patients consumed one of three types of enteral nutrition: a control or IMHP with and without β-glucan. The IMHP with β-glucan group showed increases in natural killer (NK) cell activities relative to the baseline, and greater increases were observed in NK cell activities relative to the control group after adjusting for age and gender. The IMHP groups with and without β-glucan had greater increases in serum prealbumin and decreases in high-sensitivity C-reactive protein (hs-CRP) than the control group. The control group had a greater decrease in peripheral blood mononuclear cell (PBMC) interleukin (IL)-12 production than the IMHP with and without β-glucan groups. In all patients, the change (Δ) in hs-CRP was correlated with Δ prealbumin and Δ PBMC IL-12, which were correlated with ΔNK cell activity and Δ prealbumin. This study showed beneficial effects of a combination treatment of β-glucan and IMHP on NK cell activity. Additionally, strong correlations among changes in NK cell activity, PBMC IL-12, and hs-CRP suggested that β-glucan could be an attractive candidate for stimulating protective immunity without enhanced inflammation (ClinicalTrials.gov: NCT02569203).

show abstract

Section: Discussionsupporting

confidence: 90%

Effect of Immune-Enhancing Enteral Nutrition Enriched with or without Beta-Glucan on Immunomodulation in Critically Ill Patients

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The level of evidence for an anti-inflammatory effect of n -3 PUFA supplementation in older individuals is perhaps more solid, as shown in Table 2 . In two RCTs carried out on older individuals undergoing hip surgery [ 96 ] or admitted to ICU with critical illness [ 97 ], the intravenous administration of fish oil-based lipid emulsions for eight days was effective to increase the circulating levels of the anti-inflammatory cytokine IL-10. A decrease in serum levels of IL-8, TNF-α and IL-6 levels was also observed [ 96 , 97 ].…”

Section: N -3 Polyunsaturated Fatty Acids and Imentioning

confidence: 99%

“…In two RCTs carried out on older individuals undergoing hip surgery [ 96 ] or admitted to ICU with critical illness [ 97 ], the intravenous administration of fish oil-based lipid emulsions for eight days was effective to increase the circulating levels of the anti-inflammatory cytokine IL-10. A decrease in serum levels of IL-8, TNF-α and IL-6 levels was also observed [ 96 , 97 ]. Interestingly, Berger et al , in a RCT enrolling both adult and geriatric patients undergoing cardiopulmonary bypass surgery, showed that n -3 PUFA decreased the perioperative inflammation [ 98 ].…”

Section: N -3 Polyunsaturated Fatty Acids and Imentioning

confidence: 99%

Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins

et al. 2016

View full text Add to dashboard Cite

Chronic activation of the inflammatory response, defined as inflammaging, is the key physio-pathological substrate for anabolic resistance, sarcopenia and frailty in older individuals. Nutrients can theoretically modulate this phenomenon. The underlying molecular mechanisms reducing the synthesis of pro-inflammatory mediators have been elucidated, particularly for vitamin D, n-3 polyunsaturated fatty acids (PUFA) and whey proteins. In this paper, we review the current evidence emerging from observational and intervention studies, performed in older individuals, either community-dwelling or hospitalized with acute disease, and evaluating the effects of intake of vitamin D, n-3 PUFA and whey proteins on inflammatory markers, such as C-Reactive Protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α). After the analysis, we conclude that there is sufficient evidence for an anti-inflammatory effect in aging only for n-3 PUFA intake, while the few existing intervention studies do not support a similar activity for vitamin D and whey supplements. There is need in the future of large, high-quality studies testing the effects of combined dietary interventions including the above mentioned nutrients on inflammation and health-related outcomes.

show abstract

“…Short-term intravenous administration of FO-based lipid emulsion (0.2 g/kg body weight) over 6 h for 3 consecutive days in critically ill enterally fed elderly patients in the first 48 h of intensive care unit (ICU) admission increased energy intake and serum IL-10 concentration, decreased serum tumor necrosis factor-α and IL-8 concentrations, occurring around 7–9 days of ICU stay, thereby expressing an anti-inflammatory effect [ 45 ]. Three perioperative infusions of 0.2 g/kg FO emulsion 12 and 2 h before and immediately after surgery significantly increased EPA and DHA concentrations in platelet and atrial tissue membranes within 12 h of the first supplementation and decreased systemic inflammation induced by a cardiopulmonary bypass thus suggesting benefits in elective cardiac surgery patients.…”

Section: Effects Of Omega-3 Pufas On Immune Functionmentioning

confidence: 99%

The Role for Dietary Omega-3 Fatty Acids Supplementation in Older Adults

2014

View full text Add to dashboard Cite

Optimal nutrition is one of the most important determinants of healthier ageing, reducing the risk of disability, maintaining mental and physical functions, and thus preserving and ensuring a better quality of life. Dietary intake and nutrient absorption decline with age, thus increasing the risk of malnutrition, morbidity and mortality. Specific nutrients, particularly long-chain omega-3 polyunsaturated fatty acids (PUFAs), might have the potential of preventing and reducing co-morbidities in older adults. Omega-3 PUFAs are able to modulate inflammation, hyperlipidemia, platelet aggregation, and hypertension. Different mechanisms contribute to these effects, including conditioning cell membrane function and composition, eicosanoid production, and gene expression. The present review analyzes the influence of omega-3 PUFAs status and intake on brain function, cardiovascular system, immune function, muscle performance and bone health in older adults. Omega-3 FAs may have substantial benefits in reducing the risk of cognitive decline in older people. The available data encourage higher intakes of omega-3 PUFAs in the diet or via specific supplements. More studies are needed to confirm the role of omega-3 FAs in maintaining bone health and preventing the loss of muscle mass and function associated with ageing. In summary, omega-3 PUFAs are now identified as potential key nutrients, safe and effective in the treatment and prevention of several negative consequences of ageing.

show abstract

Pharmaconutrition

Abstract: Short-term IV FLE modulates some inflammatory markers in critically ill elderly patients receiving enteral nutrition (EN), suggesting an anti-inflammatory effect. This may be a benefit and suggests a role for FLE administration as a supplement in elderly ICU patients receiving standard EN.

Cited by 20 publications

References 46 publications

Effect of Immune-Enhancing Enteral Nutrition Enriched with or without Beta-Glucan on Immunomodulation in Critically Ill Patients

Effect of Immune-Enhancing Enteral Nutrition Enriched with or without Beta-Glucan on Immunomodulation in Critically Ill Patients

Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins

The Role for Dietary Omega-3 Fatty Acids Supplementation in Older Adults

Contact Info

Product

Resources

About