Pharmacophoric 2‐Hydroxyalkyl Benzenesulfonamide: A Single‐Step Synthesis from Benzenesulfonamide via Hemiaminal.

Abstract

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Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives

“…The sulfonamide of paramount importance in this study is benzenesulfonamide which is an integral part of many drugs and drug-like scaffolds [17,18]. Many derivatives of benzenesulfonamide have been explored as important starting materials and reactive intermediates in various organic syntheses [19]. For example, 2-hydroxyalkylbenzene sulfonamides have been reported as the important starting materials produced in large quantities.…”