Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

Abstract

The literature on the sexual side effects of drugs and chemicals has been reviewed. There are many substances which alter the human sociosexual response cycle either negatively, positively or both. Many of the drugs used therapeutically have been reported to have adverse effects on sexuality, and this must be taken into account when these drugs are used clinically. Many substances which are used for recreational purposes (or sometimes abused) also have profound effects on sexual response. Many of these substances are used in such a way that they can correct underlying sexual problems. Treatment of a drug abuser may well prove unsuccessful without consideration of preexistent sociosexual problems and concerns. From the dawn of recorded history, many substances have been used for the purpose of sexual enhancement. Some of these have known success and their reputations have been passed down through the millenia. The chapter has not yet been closed on aphrodisiacs, even though none have survived the rigors of scientific scrutiny. As long as humans place value on optimal sexual functioning, there will be a demand for sex-enhancing drugs. In order for the scientific and medical community to successfully meet these challenges, more effective and relevant study designs will have to be utilized in order to separate fact from fancy. The study of pharmacosexology is in its infancy, and in order for it to grow and contribute to the world body of knowledge, more researchers and clinicians must be trained in both pharmacology and sexology.

Erectile Dysfunction Associated with Psychoactive Substances

“…New or infrequent cocaine users may report that cocaine induces spontaneous erection and ejaculation. 65 However, other research reported that ambiguous findings of cocaine's impact on sexuality might be due to variation in the dosage, route of administration or other factors. 66 MacDonald et al found that of men who had used cocaine for 1 year or longer, 66% reported to have erection difficulties.…”

Prostate cancer and sexual function

“…14 Drugs which signi®cantly decrease testosterone synthesis or block utilization have been associated with decreased libido. 15 LHRH analogues reduce serum testosterone levels, while antiandrogens competitively inhibit the binding of testosterone and dihydrotestosterone to the androgen receptor thereby blocking the stimulatory activity of the two steroidal androgens. Steroidal antiandrogens also inhibit LHRH secretion resulting in a reduction of testosterone secretion.…”

Analysis of Moral Judgement by Using Reproductive System Case Dilemma In High School Students

“…The relationship between alcohol, drugs, and sexual function is very complex [2]. The problem of moral violations as described can not be approached only from one aspect, because reproductive health is affected and influences social systems and is closely related to values, morals, religions and cultures.…”