Pharmacotherapy and surgical treatment of lately diagnosed advanced destructive pulmonary tuberculosis in adolescents

Панова, Л.В.; Ovsyankina, E.S.; Bagirov, Mamad; Poluektova, F. A.; Khiteva, A.Yu.; Krushinskaya, Ekaterina

doi:10.20953/1729-9225-2019-3-97-104

Infekc. bolezni

2019

DOI: 10.20953/1729-9225-2019-3-97-104

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Pharmacotherapy and surgical treatment of lately diagnosed advanced destructive pulmonary tuberculosis in adolescents

Л.В. Панова¹,

E.S. Ovsyankina²,

Mamad Bagirov³

et al.

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2024

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Cited by 2 publications

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Short-Course Chemotherapy Regimens for Treatment of Multiple and Pre-Extensive Drug Resistant Tuberculosis in Combination with Surgery in Older Children and Adolescents

Ovsyankina,

Panova,

Krushinskaya

et al. 2024

Tuberk. bolezni lëgk.

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The objective: to evaluate the eﬀectiveness of short-curse chemotherapy regimens for treatment of MDR/pre-XDR tuberculosis in combination with surgery in older children and adolescents.Subjects and Methods. 51 patients with MDR/pre-XDR respiratory tuberculosis aged 13-17 years were enrolled in a prospective open study (2017-2021). The statistical correlation between certain factors and prescription of continuous or short-course chemotherapy to a patient after surgery was calculated using the Pearson χ² test.Results. Of the 51 patients, short-course chemotherapy regimen (12 months) was administered to 37 (72.5%) patients, while continuous treatment regimen (13 months or more) was used in 14 (27.5%) patients. It was found that surgical treatment was taken into account as a risk factor when prescribing continuous chemotherapy (χ² = 5.307; p = 0.022). In 40 operated patients, continuous chemotherapy was statistically signiﬁcantly more often prescribed when following factors were observed: surgery after 10 months and more after the start of treatment (χ² = 21.567; p < 0.001), two-stage surgery (χ² = 8.254; p = 0.005), and tuberculosis progression after surgery (χ² = 3.910; p = 0.049). TB relapses after a year of follow-up in the patients treated with continuous chemotherapy regimens made 11%, while in case of short-course treatment, they were 9%. The results of our study indicate the possibility of using short-course chemotherapy regimens in combination with surgical treatment.

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Short-Course Chemotherapy Regimens for Treatment of Multiple and Pre-Extensive Drug Resistant Tuberculosis in Combination with Surgery in Older Children and Adolescents

Ovsyankina,

Panova,

Krushinskaya

et al. 2024

Tuberk. bolezni lëgk.

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Effectiveness and Safety of New Chemotherapy Regimens in Patients with HIV-associated MDR TB and Viral Hepatitis C

Kukurika,

Peregudova,

Parolina

et al. 2024

Tuberk. bolezni lëgk.

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The objective: to study the eﬀectiveness and safety of new chemotherapy regimens at the end of the intensive phase in the patients suﬀering from multiple drug resistant tuberculosis (MDR TB), concurrent HIV infection (HIV), and chronic hepatitis C (HCV).Subjects and Methods. The eﬀectiveness and safety of MDR TB treatment regimens containing bedaquiline, linezolid, delamanid, and clofazimine in various combinations were studied in 68 patients with the triple infectious disease MDR TB/HIV/HCV. The control group included 64 patients receiving treatment with the regimens free of these drugs.Results. Bacteriological effectiveness was achieved in all patients. In the group of new drugs, the timing was shorter: culture conversion after taking 30 doses was registered in 70.6% versus 43.8% of patients in the control group. Positive radiographic changes such as decreased focal infiltrative shadows, were noted in 41.1% versus 25% of patients, cavity healing was observed in 18.1% versus 5.1% of patients, respectively. The incidence of adverse reactions (ARs) was higher in the control group (90.6% vs. 52.9%). In both groups, the most common adverse event outcome was discontinuation of one anti-tuberculosis drug (69% vs. 42%).Conclusion. Chemotherapy regimens containing new anti-tuberculosis drugs are more eﬀective and have a more favorable safety proﬁle.

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Pharmacotherapy and surgical treatment of lately diagnosed advanced destructive pulmonary tuberculosis in adolescents

Cited by 2 publications

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Short-Course Chemotherapy Regimens for Treatment of Multiple and Pre-Extensive Drug Resistant Tuberculosis in Combination with Surgery in Older Children and Adolescents

Short-Course Chemotherapy Regimens for Treatment of Multiple and Pre-Extensive Drug Resistant Tuberculosis in Combination with Surgery in Older Children and Adolescents

Effectiveness and Safety of New Chemotherapy Regimens in Patients with HIV-associated MDR TB and Viral Hepatitis C

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