Pharmacotherapy for obesity in menopausal women

Samat, Ashish; Rahim, Asad; Barnett, Anthony

doi:10.1258/mi.2008.008005

Cited by 17 publications

(12 citation statements)

References 52 publications

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“…The normotensive postmenopausal females showed higher body weight than their premenopausal counterparts in the present study. Different ethnic origin, reduced lean mass, resting metabolic rate, and treatment with certain drugs could be responsible for weight gain among postmenopausal women (Samat, Rahim, & Barnett, 2008). All the premenopausal and postmenopausal women in both prehypertensive and hypertensive categories were found to have abdominal obesity.…”

Section: Discussionmentioning

confidence: 99%

Bio-Social Predictors of Hypertension Among Premenopausal and Postmenopausal Women

Tyagi¹,

Dhall

Kapoor

2015

Sage Open

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In the present study, the contribution of various biological and lifestyle factors toward progression to hypertension are examined among menopausal and postmenopausal women. A cross-sectional study among 245 women of 20 to 65 years was conducted. Besides blood pressure, fat percentage using bio-electric impedance analyzer and adiposity indices such as body mass index (BMI), waist-hip ratio (WHR), and waist-height ratio (WHtR) were taken. Mean, standard deviation, ANOVA, and multinomial logistic were used to analyze the data. Statistically significant differences (p< .001) for blood pressure among postmenopausal and premenopausal women were found. Among both premenopausal and postmenopausal women, the prehypertensive and hypertensive group showed significant differences with the normotensive women for body weight (p< .005), regional obesity, and general obesity. Low educational level, working status of women, socioeconomic status, nuclear family setup, postmenopausal status, and obesity were found to be the likely risk factors for prehypertension or hypertension among women.

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Section: Discussionmentioning

confidence: 99%

Bio-Social Predictors of Hypertension Among Premenopausal and Postmenopausal Women

Tyagi¹,

Dhall

Kapoor

2015

Sage Open

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“…All the licensed drugs such as orlistat and sibutramine have shown to be effective and are reasonably tolerated (reviewed by Samat et al, 2008). However their use should only be limited to women in whom lifestyle interventions are unfeasible or unsustainable.…”

Section: Pharmacological and Surgical Treatment Of Obesity In Postmenmentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

136

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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“…3 Metabolic syndrome, characterised by insulin resistance, 6, 7 accounts for an estimated 48% of coronary events in postmenopausal women. 4 Observational studies provide evidence for increasing body fatness 8, 9, 10 and deterioration of the lipid profile with the menopause; 11 however, evidence of effective interventions designed to prevent menopausal weight gain is lacking.…”

Section: Introductionmentioning

confidence: 99%

Can a relatively low-intensity intervention by health professionals prevent weight gain in mid-age women? 12-Month outcomes of the 40-Something randomised controlled trial

et al. 2014

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Background:Weight gain in perimenopausal women results in increased visceral adipose tissue, leading to metabolic syndrome and associated comorbidities. Despite a high prevalence of weight gain at this life stage, interventions to prevent menopausal obesity are lacking.Aim:To test the effectiveness of an intervention delivered by health professionals using a motivational interviewing (MI) counselling style in preventing weight gain in non-obese (body mass index (BMI) 18.5 and 29.9 kg m−2) women in late premenopause.Methods:In a randomised controlled trial, 54 women (mean (s.d.) age 47.3 (1.8) years; BMI 25.1 (2.4) kg m−2) who had menstruated within the preceding 3 months were randomly assigned to an MI intervention (n=28) (five health professional MI counselling sessions) or a self-directed intervention (SDI) (print materials only) (n=26). The primary outcome, body weight (kg) and secondary outcomes (blood lipids, glucose, body fat %, lean mass % and waist circumference) were measured at baseline and postintervention (12 months), and intention-to-treat analysis was conducted.Results:Forty women completed all measures and adhered to all protocols. The weight at 12 months for the MI group of 65.6 kg (95% CI: 64.5; 66.8) was significantly different (P=0.034) from the SDI group of 67.4 kg (95% CI: 66.2; 68.6). When stratified by baseline BMI category, the MI group lost significantly more weight (−2.6 kg; 95% CI: −3.9; −1.2) than the SDI group (−0.1 kg; 95% CI: −1.2; 1.0, P=0.002) for the healthy weight women. The overweight women lost weight regardless of the intervention group, with no between-group difference (−3.5 kg; 95% CI: −6.1, −1.0 and −2.3; 95% CI: −4.1, −0.5, P=0.467).Conclusion:This relatively low-intensity intervention, incorporating MI into health professional counselling, not only effectively prevented weight gain but also achieved significant weight loss and decreased diastolic blood pressure. Further refinements are required to optimise outcomes for overweight women.

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Pharmacotherapy for obesity in menopausal women

Cited by 17 publications

References 52 publications

Bio-Social Predictors of Hypertension Among Premenopausal and Postmenopausal Women

Bio-Social Predictors of Hypertension Among Premenopausal and Postmenopausal Women

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Can a relatively low-intensity intervention by health professionals prevent weight gain in mid-age women? 12-Month outcomes of the 40-Something randomised controlled trial

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