Pharmacotherapy for pediatric chronic intestinal pseudo‐obstruction: Nationwide survey in Japan

Hashizume, Naoki; Yagi, Minoru; Ushijima, Kosuke; Seki, Yoshitaka; Fukahori, Suguru; Muto, Mitsuru; Matsufuji, Hiroshi; Taguchi, Tomoaki

doi:10.1111/ped.13201

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…There is a single report of a child with myopathic CIPO treated with cisapride and subsequently with tegaserod before they were withdrawn from the market (257). In a nationwide Japanese survey of medications used in PIPO, the selective 5HT4 agent mosapride accounted for 70% of prokinetics used, however limited data was available as to its efficacy (258).…”

Section: 3 Drugs/pharmacotherapymentioning

confidence: 99%

“…In a description of its use in 2 cases DKT was found to be effective in a case of megacystis-microcolon-intestinal hypoperistalsis syndrome, but not in one with CIPO (271). A recent nationwide survey in Japan regarding pharmacotherapy in patients with PIPO revealed widespread use of conventional and traditional pharmaco-therapeutic agents including prokinetics, probiotics, laxatives and Japanese herbal (Kampo) medicines (258).…”

Section: Loe:mentioning

confidence: 99%

See 1 more Smart Citation

Paediatric Intestinal Pseudo‐obstruction

Thapar

Saliakellis

Benninga

et al. 2018

J. pediatr. gastroenterol. nutr.

121

224

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Section: 3 Drugs/pharmacotherapymentioning

confidence: 99%

Section: Loe:mentioning

confidence: 99%

Paediatric Intestinal Pseudo‐obstruction

Thapar

Saliakellis

Benninga

et al. 2018

J. pediatr. gastroenterol. nutr.

121

224

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“…Traditional Kampo medicines (daikenchuto and rikkunshito) have also been trialled in combination with probiotics with promising effects on intestinal motility and constipation. The postulated mechanisms relate to stimulation of the cholinergic pathways and interactions with serotonergic receptors including 5HT-3 and 5HT-4 [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Paediatric intestinal pseudo-obstruction: a scoping review

2022

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Paediatric intestinal pseudo-obstruction (PIPO) encompasses a group of rare disorders in which patients present with the clinical features of bowel obstruction in the absence of mechanical occlusion. The management of PIPO presents a challenge as evidence remains limited on available medical and surgical therapy. Parenteral nutrition is often the mainstay of therapy. Long-term therapy may culminate in life-threatening complications including intestinal failure-related liver disease, central line thrombosis and sepsis. Intestinal transplantation remains the only definitive cure in PIPO but is a complex and resource-limited solution associated with its own morbidity and mortality. We conducted a scoping review to present a contemporary summary of the epidemiology, aetiology, pathophysiology, diagnosis, management and complications of PIPO.Conclusion: PIPO represents a rare disorder that is difficult to diagnose and challenging to treat, with significant morbitity and mortality. The only known cure is intestinal transplantation. What is Known:• Paediatric intestinal pseudo-obstruction is a rare, heterogeneous disorder that confers a high rate of morbidity and mortality• Complications of paediatric intestinal pseudo-obstruction include chronic pain, small intestine bacterial overgrowth and malrotation. Other complications can occur related to its management, such as line infections with parenteral nutrition or cardiac side effects of prokinetic medications What is New:• Progress in medical and surgical therapy in recent years has led to improved patient outcomes• Enteral autonomy has been reported in most patients at as early as 1 month post-transplantation

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“…Probiotika werden teils in der Therapie von CIPO-Patienten eingesetzt 131 , es liegen aber keine Studien zur Wirksamkeit vor.…”

Section: Therapieunclassified