Pharmacotherapy for sleep bruxism

Macedo, Cristiane R; Machado, Marco Antônio Cardoso; Silva, Ademir B; Prado, Gilmar Fernandes do

doi:10.1002/14651858.cd005578

Cited by 8 publications

(14 citation statements)

References 12 publications

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“…[16][17][18] The current treatments for SB include occlusal splints, biofeedback, kinesiotherapy, and repetitive transcranial magnetic stimulation, electrical stimulation as well as drug intake such as clonidine. [19][20][21][22][23][24][25] However, most of the therapies could be only used to protect teeth and their associated structures and none of them can effectively prevent the occurrence of SB without severe side effects.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of the relationships between rhythmic masticatory muscle activities and limb movements in patients with sleep bruxism

Han

Wang

Zhong

et al. 2019

J of Oral Rehabilitation

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Summary Background Most rhythmic masticatory muscle activities (RMMAs) have been shown to be accompanied with limb movements (LMs) in sleep bruxism (SB) patients during sleep. Objectives To compare the relationships between RMMAs and LMs in SB patients and normal subjects. Methods Polysomnographic recordings were performed on eight SB patients and nine normal subjects and the frequencies and durations of RMMAs as well as LMs were determined. Linear regression and correlation analysis were performed to study the relationship between durations of RMMAs and LMs when RMMAs occurred with LMs. Results Most LMs in SB patients, but not in normal subjects, were accompanied with RMMAs. RMMAs in SB patients were more likely to be isolated, phasic or mixed, while RMMAs in normal subjects were more likely to be tonic. The frequencies of LMs, isolated RMMAs and RMMAs accompanied with LMs in SB patients were significantly higher than those in normal subjects. Furthermore, linear regression and correlation analysis showed that duration of RMMAs was significantly associated with that of LMs when RMMAs occurred with LMs. The duration of RMMAs, when accompanied with LMs, in SB patients was significantly longer than that in normal subjects. Conclusions Close relationships between LMs and RMMAs exist in SB patients and normal subjects, and SB episodes may be part of cortical arousal responses and the increased cortical activities associated with SB episodes may not just be localised to the central nervous system (CNS) that controls jaw movements but may also include other parts of CNS that controls LMs.

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Section: Introductionmentioning

confidence: 99%

Characterisation of the relationships between rhythmic masticatory muscle activities and limb movements in patients with sleep bruxism

Han

Wang

Zhong

et al. 2019

J of Oral Rehabilitation

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“…Since that time, knowledge on bruxism has likely been improved, especially as far as the aetiology and clinical relevance of the various bruxism-related motor phenomena are concerned. In addition, other literature reviews were performed on selected bruxism management topics (8)(9)(10)(11). Notwithstanding that, findings still offer a fragmental picture and the need for a state-of-the-art summary has emerged.…”

Section: Introductionmentioning

confidence: 99%

Management of sleep bruxism in adults: a qualitative systematic literature review

Manfredini

Ahlberg

Winocur

et al. 2015

J of Oral Rehabilitation

164

130

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This paper updates the bruxism management review published by Lobbezoo et al. in 2008 (J Oral Rehabil 2008; 35: 509-23). The review focuses on the most recent literature on management of sleep bruxism (SB) in adults, as diagnosed with polysomnography (PSG) with audio-video (AV) recordings, or with any other approach measuring the sleep-time masticatory muscles' activity, viz., PSG without AV recordings or electromyography (EMG) recorded with portable devices. Fourteen (N = 14) papers were included in the review, of which 12 were randomised controlled trials (RCTs) and 2 were uncontrolled before-after studies. Structured reading of the included articles showed a high variability of topics, designs and findings. On average, the risk of bias for RCTs was low-to-unclear, whilst the before-after studies had several methodological limitations. The studies' results suggest that (i) almost every type of oral appliance (OA) (seven papers) is somehow effective to reduce SB activity, with a potentially higher decrease for devices providing large extent of mandibular advancement; (ii) all tested pharmacological approaches [i.e. botulinum toxin (two papers), clonazepam (one paper) and clonidine (one paper)] may reduce SB with respect to placebo; (iii) the potential benefit of biofeedback (BF) and cognitive-behavioural (CB) approaches to SB management is not fully supported (two papers); and (iv) the only investigation providing an electrical stimulus to the masseter muscle supports its effectiveness to reduce SB. It can be concluded that there is not enough evidence to define a standard of reference approach for SB treatment, except for the use of OA. Future studies on the indications for SB treatment are recommended.

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“…Psychosocial factors, such as stress and behavioral changes, are typically reported in association with bruxism. Various treatments have been reported for bruxism, including intraoral guards, drugs (benzodiazepines, dopamine agents, antidepressants, muscle relaxants, and beta blockers), botulinum toxin injection, dental surgery, psychosocial interventions (i.e., relaxation techniques, stress management, and behavioral modification), physical therapy (isokinetic stretching exercises and mandibular exercises), manual therapy, and electrophysical modalities (ultrasound, shortwave diathermy, low-intensity laser therapy, transcutaneous electrical stimulation, biofeedback training, and muscular awareness relaxation therapy) [6][7][8]; however, there is no consensus concerning which is most effective.…”

Section: Discussionmentioning

confidence: 99%

Botulinum toxin injection for bruxism associated with brain injury: Case report

Kesikburun¹,

Alaca²,

Aras³

et al. 2014

J Rehabil Res Dev

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Abstract-Bruxism is involuntary grinding of the teeth and can occur as a complication of brain injury. If untreated, bruxism can lead to severe occlusal trauma. Herein, we present a patient with traumatic brain injury and nocturnal bruxism that was treated with botulinum toxin injection. A 21 yr old male patient with traumatic brain injury from a car accident was admitted to our inpatient rehabilitation unit. He had a history of coma for 2 wk in the intensive care unit. The initial cranial computed tomography scan indicated a superior thalamic hemorrhage. On admission to our department 3 mo postinjury, his mental status was good and he was able to walk without assistance, but he had mild ataxia. He complained about severe teeth grinding at night, which began 2 mo postinjury. Botulinum toxin-A was injected into the masseter muscles (20 U in each muscle) and temporalis muscles (15 U in each muscle) bilaterally. A decrease in bruxism was reported within 3 d. Clinical improvement persisted at assessment 4 mo posttreatment. Botulinum toxin injection can be used as an effective treatment for bruxism associated with brain injury.

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Pharmacotherapy for sleep bruxism

Cited by 8 publications

References 12 publications

Characterisation of the relationships between rhythmic masticatory muscle activities and limb movements in patients with sleep bruxism

Characterisation of the relationships between rhythmic masticatory muscle activities and limb movements in patients with sleep bruxism

Management of sleep bruxism in adults: a qualitative systematic literature review

Botulinum toxin injection for bruxism associated with brain injury: Case report

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