Pharmacotherapy for trichotillomania

Rothbart, Rachel; Amos, Taryn; Siegfried, Nandi; Ipser, Jonathan; Fineberg, Naomi; Chamberlain, Samuel R.; Stein, Dan J.

doi:10.1002/14651858.cd007662.pub2

Cited by 59 publications

(56 citation statements)

References 56 publications

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“…In another review of trials assessing the effect of opioid antagonists in behavioural addictions (which included trichotillomania), it was concluded that there is not enough evidence to support the use of opioid antagonists such as naltrexone or nalmefene in trichotillomania [124] . Similarly, there was a Cochrane review published in 2013 which also noted that the literature do not provide strong evidence of a treatment effect for naltrexone in trichotillomania [125] .…”

Section: Discussionmentioning

confidence: 99%

Rapid effect of naltrexone in the treatment of trichotillomania

Ahmadi¹,

Pridmore²

2017

JAD

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Background: Trichotillomania is not a public disease. Objective: To scrutinize the function of naltrexone in the treatment of trichotillomania. Case report: In this report, we present a case of chronic trichotillomania with opioid induced depressive disorder in a 35 year old male. He was successfully treated by administering naltrexone 25 mg per day for one week without any side effects. We observed that 25 mg of naltrexone per day has a rapid effect in reduction and cessation of chronic trichotillomania. Results: Naltrexone could be valuable in the treatment of trichotillomania. Discussion: This work points out that naltrexone may be effective in the treatment of trichotillomania. Therefore this finding could be an original and new addition to the literature. Conclusions: This study resulted in efficacy of naltrexone in the management of trichotillomania. However, we require a larger sample size to be able to generalize this finding.

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Section: Discussionmentioning

confidence: 99%

Rapid effect of naltrexone in the treatment of trichotillomania

Ahmadi¹,

Pridmore²

2017

JAD

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“…Trichotillomania also shares a strong similarity with OCD in terms of underlying abnormalities in corticostriatal pathways as well as some associated impairments in the cognitive abilities linked to the integrity of these brain structures [18,49]. However, in contrast to OCD, trichotillomania is not consistently responsive to serotonin-based pharmacotherapy; it also shows a better response to an non-selective serotonin reuptake inhibitor clomipramine than to SSRIs [50]. Therefore, CBT is typically recommended as the first line of treatment for trichotillomania, especially in children [48].…”

Section: Trichotillomania and Skin Picking Disordermentioning

confidence: 99%

From anxiety to compulsivity – a review of changes to OCD classification in DSM-5 and ICD-11

Krzanowska¹,

Kuleta²

2017

Arch Psych Psych

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SummaryObsessive-compulsive disorder (OCD) is no longer classified as an anxiety disorder in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). It has become a flagship disorder of the new category of Obsessive Compulsive and Related Disorders (OCRDs) -a group of five disorders linked together by the core symptom of repetitive thoughts and behaviors and phenomenological and neurobiological similarity to OCD. Body dysmorphic disorder, hoarding disorder, trichotillomania, and skin picking disorder are the other disorders included in this group. In the upcoming eleventh edition of the International Classification of Diseases (ICD)-11, the World Health Organization (WHO) is planning to introduce similar changes to its own classification of OCD, further recommending the inclusion of olfactory reference disorder and hypochondriasis, in addition to the disorders listed in the DSM-5. In this article, we will review the classifications of OCD and OCDRs in the DSM-5 and the upcoming ICD-11, as well as describe the rationale and research leading to the creation of this new class of disorders.

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“…Two reviews contained studies with quasiexperimental methods [63,64]. Two reviews in this group did not conduct quantitative synthesis of estimates [61,62], whereas one review meta-analyzed the data for only one outcome, involving two trials [68].…”

Section: Description Of Included Studiesmentioning

confidence: 99%