Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus

Abstract

Fluoxetine, orlistat, and sibutramine can achieve statistically significant weight loss over 12 to 57 weeks. The magnitude of weight loss is modest, however, and the long-term health benefits remain unclear. The safety of sibutramine is uncertain. There is a paucity of data on other drugs for weight loss or control in persons with type 2 diabetes.

Anti-diabetic effect of Coffea arabica, in alloxan-induced diabetic rats

“…Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from the altered insulin secretion, insulin action, or both (Norris et al, 2009). Chronic hyperglycemia of DM is associated with long-term damage, dysfunction and organ failure as particularly eyes, kidneys, nerves, heart and blood vessels (Guzmán et al, 2010).…”

Retinal function and histopathology in rabbits treated with Topiramate

“…9 Initially, complex epilepsy was the only indication for treatment with topiramate. Recently it has been suggested that topiramate may be useful in the treatment of obesity [10][11][12][13][14][15] , eating disorders [16][17][18][19][20] , migraine [21][22][23][24][25][26][27][28][29][30][31] , bipolar disorders [32][33][34][35] , other psychiatric disorders [36][37][38][39][40][41][42] , alcohol dependence [43][44][45][46][47] and other addictive disorders 48 . Also the drug is more frequently used in the management of childhood epilepsy [49][50][51] .…”

The Management of Metabolically Unhealthy Obesity

“…당뇨병이 있는 과체중 혹은 비만 성인의 경우에는 5~10% 정도 체중감량을 통해 당화혈색소를 0.6~1.0% 감소시킬 수 있고, 또한 당뇨 약제의 처방 필요성도 줄여준다 [35][36][37]. 체중감량의 양이 많을수록 지질대사의 호전 정도 역시 높으며 [35,38], 심혈관계 위험이 높은 과체중 혹 은 비만 성인에서는 체중감량의 양이 많을수록 혈압 저 하 효과도 더 높은 것으로 나타났다 [35,39] …”