Pharmacotherapy in Anaemia of Pregnancy: Comparison of Oral Ferrous Sulphate, Intravenous Iron Sucrose

Abstract

Aim: To analyse the outcome of oral and intravenous therapy of iron preparations in treating anaemia in pregnant women. Study Design: Prospective Study. Place and duration of study: Department of Pharmacology and department of Gynaecology and obstetrics, Khawaja Muhammad Safdar Medical College, Sialkot from May 2020 to July 2021. Methods: Between May 2020 and July 2021; A total of 1200 patients presenting to obstetric department with anaemia were included in the study after fulfilling inclusion criteria. Pregnant patients with haemoglobin level 7-8gm/dl at 24th week of gestation were included in the study. The therapy was started on 24th week of gestation. The haemoglobin levels were determined at 24th week and then at 37th week of gestation. The increase in the haemoglobin level was then determined. Serum ferritin levels were done at 37th week of gestation. Results: It was observed that there was an increase in the haemoglobin level after all the treatment regimes. The increase in haemoglobin in the group B and C was statistically significant with P value of < 0.001 when compared with the group A. However, no statistical significant difference was observed between group B and group C. Conclusion: The haemoglobin and serum ferritin level were significantly increased in the subjects after oral ferrous sulphate, however parenteral formulation are more effective in noncompliant patient where quick improvement in haemoglobin levels are to be achieved. Keywords: Anaemia, pregnancy, iron deficiency, pharmacotherapy

Clinical effectiveness of ferric carboxymaltose (iv) versus iron sucrose (iv) in treatment of iron deficiency anaemia in pregnancy: A systematic review and meta-analysis

“…1 ). A total of 18 articles that addressed one or more of the outcomes were included of which seven studies compared iv FCM and iv ISC (five RCTs 7 16 17 18 19 and two retrospective audits) 20 21 and 11 were observational studies 22 23 24 25 26 27 28 29 30 31 32 on safety and effectiveness of iv FCM.…”

“…Out of the five RCTs, four were conducted in India 7 16 17 19 and one in Pakistan 18 . One retrospective audit each from Switzerland 20 and Australia 21 were included.…”

“…Risk of bias and critical appraisal of studies reviewed : The risk of bias of the included RCTs, retrospective audits and observational studies is presented in tables in the Supplementary material . Two RCTs 17 18 had a moderate risk of bias due to some concerns in selective reporting. The other three RCTs 7 16 19 had a low overall risk of bias.…”