Pharmacotherapy in leishmaniasis: old, new treatments, their impacts and expert opinion

Sampaio, Raimunda Nonata Ribeiro

doi:10.1080/14656566.2022.2157208

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…The transmission of the disease occurs through approximately 90 species of sandflies, which can transmit the Leishmania parasites. These parasites consist of more than 20 species and contribute to an annual death toll of 20,000 to 30,000 [3]. Currently, there is no specific therapeutic treatment available for leishmaniasis.…”

Section: Introductionmentioning

confidence: 99%

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Mohamed Abdoul-Latif,

Ainane,

Aboubaker

et al. 2023

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In this study, anti-leishmanial activities were performed on silver oxide nanoparticles green synthesized from hexane, ethereal, chloroform, and methanolic extracts of the Ericaria amentacea seaweed. The extracts were obtained using a soxhlet extraction system, and the silver oxide nanoparticles were synthesized through a simple and environmentally friendly method. Physicochemical characterizations, including UV spectrophotometry, transmission electron microscopy (TEM), X-ray diffraction (XRD), thermal gravimetry analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and zeta potential analysis (ZPA), were conducted to confirm the formation of silver oxide particles. The anti-leishmanial activity was evaluated in vitro using the MTT assay against the Leishmania infantum, Leishmania tropica, and Leishmania major strains. Additionally, a brine shrimp cytotoxicity test was performed on Artemia salina larvae to assess the toxicity of the products. The results showed that the anti-leishmanial activity of the synthesized silver oxide nanoparticles was significant, with inhibitory concentration values ranging from 27.16 μg/mL to 38.18 μg/mL. The lethal doses in the cytotoxicity activities were higher than 17.08 μg/mL, indicating low toxicity. These findings suggest that silver oxide nanoparticles derived from Ericaria amentacea seaweed have potential applications in the treatment of leishmaniasis. Further research is needed to elucidate the mechanisms of action and assess the in vivo efficacy of these nanoparticles. Moreover, comprehensive toxicity studies are necessary before considering their clinical use in leishmaniasis treatment.

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Section: Introductionmentioning

confidence: 99%

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Mohamed Abdoul-Latif,

Ainane,

Aboubaker

et al. 2023

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Lupoid cutaneous leishmaniasis in Pakistan: a case series in school children

Ashraf,

Qadeer,

Bukhari

et al. 2024

Pathology

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Therapeutic effect of topical tamoxifen in murine cutaneous leishmaniasis caused by Leishmania major

Hassani-Abharian,

Hejazi Dehaghani,

Shahmoradi

et al. 2024

Antimicrob Agents Chemother

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Iran is one of the endemic regions of cutaneous leishmaniasis (CL) caused by Leishmania major . There is no protective vaccine available against CL available, and the most effective strategy is a definitive treatment. Topical medications can be an excellent option for this purpose. Tamoxifen, a cancer control drug, has properties such as inducing cell apoptosis and anti-parasitic activity, which can be useful in controlling eukaryotic parasites such as Leishmania . The present study was conducted to investigate this theory in experimental CL caused by L. major . Forty female BALB/c mice aged 4 to 6 weeks were infected by injecting 1 × 10 6 L. major metacyclics (MRHO/IR/75/ER) in the base of the tail. After the appearance of Leishmania nodules, mice were divided into five test and control groups. Two drug formulations were used: tamoxifen 1% in ethanol and tamoxifen citrate ointment 0.1%. The effectiveness of each formula was evaluated by determining the mean size of the ulcers and parasite burden after a 28-day treatment period. Both formulations showed reduced ulcer mean sizes. However, only the tamoxifen citrate ointment group demonstrated a statistically significant reduction ( P = 0.049). The parasite burden decreased by 40.83% for the ointment group and 33.67% for the ethanol solution. Other control groups showed lesser reductions. This study partially demonstrated the effectiveness of topical tamoxifen on CL lesions in a murine model. It can provide a basis for further research on the therapeutic effects of different topical tamoxifen formulations.

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Pharmacotherapy in leishmaniasis: old, new treatments, their impacts and expert opinion

Cited by 3 publications

References 35 publications

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Lupoid cutaneous leishmaniasis in Pakistan: a case series in school children

Therapeutic effect of topical tamoxifen in murine cutaneous leishmaniasis caused by Leishmania major

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