Pharmacotherapy in patients with vasomotor disorders

Boerhout, C.K.M.; Feenstra, R.G.T.; van de Hoef, T.P.; Piek, J.J.; Beijk, M.A.M.

doi:10.1016/j.ijcha.2023.101267

Cited by 1 publication

(1 citation statement)

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“…It exerts its influence through NO and achieves enhanced myocardial perfusion by dilating the coronary arterial system [31]. Additionally, it increases the cardiac preload and elevates the peripheral venous capacitance, thus diminishing the oxygen demand [32]. Preliminary research conducted previously demonstrated that molsidomine successfully alleviated non-spatial recognition memory deficits, stereotypies, Life 2024, 14, 306 3 of 16 and ataxia induced by the NMDA receptor antagonist MK-801 in rats, but the mechanisms involved have not been completely deciphered [33,34].…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats

Mititelu-Tartau,

Bogdan,

Pavel

et al. 2024

Life

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Compelling evidence indicates that nitric oxide (NO) exerts a significant influence on the central nervous system, participates in the modulation of neurotransmitter release, contributes to the regulation of cognitive functions, and plays a crucial role in modulating various aspects of neural activity. We aimed to explore the influence of two NO donors, molsidomine (MSD) and V-pyrro/NO, on the innate spontaneous psychomotor abilities and short-term memory in rats. Using an actimeter test, the locomotor activity, stress-sensitive behavior, and anxiety level were investigated. The influence on the animal`s cognitive functions was evaluated usingthe Y-maze test to assess the spontaneous alternation percentage, number of arms visited, number of alternations, and the preference index. Four distinct groups of five white male Wistar rats were exposed to the intraperitoneal treatments as follows: Control batch—0.3 mL/100 g of body weight saline solution, Mg batch—200 mg/kbwof magnesium chloride, MSD batch—1 mg/kbw of molsidomine, and V-pyrro/NO batch—5 mg/kbwof V-pyrro/NO. The intraperitoneal administration of MSD resulted in a significant reduction in spontaneous behavior and exploratory skills but was less pronounced than the positive control drug, magnesium chloride. Conversely, treatment with V-pyrro/NO led to only a slight decrease in horizontal movements during the actimeter test. MSD administration, but not V-pyrro/NO, notably increased the rate of spontaneous alternation in the Y-maze test. Additionally, the use of MSD resulted in an increase in the blood level of brain-derived neurotrophic factor and the intensification of the antioxidant enzymes, superoxide dismutase, and glutathione peroxidase activity. In our experimental setup, we demonstrated that MSD exposure led to a decrease in spontaneous behavior, showed anxiolytic effects and antioxidant activity, and improved spatial memory acquisition in rats.

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