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Actuality: Increasing the frequency of hypertension among the young population is a socially significant problem. The insidiousness of hypertension in young people is that it has the character of a disease with few symptoms. Since hypertension plays one of the main roles in the pathogenesis of chronic disorders of cerebral blood circulation, including both arterial and venous systems, the search for pathogenetically determined medicinal approaches to the elimination of cerebrovascular disorders, especially at a young age, continues. The purpose of the study: to study the effectiveness, tolerability and safety of the combination of Flego and Cognitium in young patients with chronic cerebral ischemia (CMI) on the background of hypertension. Methods: clinical-neurological, psychodiagnostic (asthenic state scale (ASS), anxiety scores according to the Spielberger-Hanin scale and Beck depression scale, Montreal scale of cognitive function assessment (MoCA)), ultrasound examination, general scale of clinical impression, statistical. Results: 52 patients (28 men and 24 women) at a young age with AMI on the background of hypertension were examined. The median age of the examined patients was (37.7 ± 4.6) years; among them, 23 patients suffered from hypertension of the 1st century. and 29 patients with hypertension of the second stage. Patients were randomly divided into two groups - the first - 23 (44.2%) patients (received only hypotensive drugs), the second - 29 (55.8%) patients (in addition to the standard hypotensive therapy received a combination of Phlego and Cognitium). Dynamic monitoring of patients after 2 months of treatment did not show significant changes in the distribution structure of objective clinical and neurological symptoms. However, positive dynamics of indicators of cognitive functions and the psychoemotional state of the subjects were observed, as well as a statistically significant decrease in the blood flow rate in the direct sinus at the end of the 2-month course using the combination of Phlego and Cognitium (decreased from 36.27±2.84 cm/s to 25.65±1.47 cm/s.). Conclusions: The introduction of the combination of Phlego and Cognitium into the treatment of young patients with arterial hypertension and chronic brain ischemia had a positive effect on the subjective state, on indicators of asthenia, emotional and cognitive state of the patients. A significant positive effect was noted in the dynamics of venous blood flow indicators (speed of blood flow in the direct sinus). Such treatment was well tolerated by patients, had few side effects and was combined with other drugs
Actuality: Increasing the frequency of hypertension among the young population is a socially significant problem. The insidiousness of hypertension in young people is that it has the character of a disease with few symptoms. Since hypertension plays one of the main roles in the pathogenesis of chronic disorders of cerebral blood circulation, including both arterial and venous systems, the search for pathogenetically determined medicinal approaches to the elimination of cerebrovascular disorders, especially at a young age, continues. The purpose of the study: to study the effectiveness, tolerability and safety of the combination of Flego and Cognitium in young patients with chronic cerebral ischemia (CMI) on the background of hypertension. Methods: clinical-neurological, psychodiagnostic (asthenic state scale (ASS), anxiety scores according to the Spielberger-Hanin scale and Beck depression scale, Montreal scale of cognitive function assessment (MoCA)), ultrasound examination, general scale of clinical impression, statistical. Results: 52 patients (28 men and 24 women) at a young age with AMI on the background of hypertension were examined. The median age of the examined patients was (37.7 ± 4.6) years; among them, 23 patients suffered from hypertension of the 1st century. and 29 patients with hypertension of the second stage. Patients were randomly divided into two groups - the first - 23 (44.2%) patients (received only hypotensive drugs), the second - 29 (55.8%) patients (in addition to the standard hypotensive therapy received a combination of Phlego and Cognitium). Dynamic monitoring of patients after 2 months of treatment did not show significant changes in the distribution structure of objective clinical and neurological symptoms. However, positive dynamics of indicators of cognitive functions and the psychoemotional state of the subjects were observed, as well as a statistically significant decrease in the blood flow rate in the direct sinus at the end of the 2-month course using the combination of Phlego and Cognitium (decreased from 36.27±2.84 cm/s to 25.65±1.47 cm/s.). Conclusions: The introduction of the combination of Phlego and Cognitium into the treatment of young patients with arterial hypertension and chronic brain ischemia had a positive effect on the subjective state, on indicators of asthenia, emotional and cognitive state of the patients. A significant positive effect was noted in the dynamics of venous blood flow indicators (speed of blood flow in the direct sinus). Such treatment was well tolerated by patients, had few side effects and was combined with other drugs
Introduction. Over the past three years, the population of Ukraine has faced chronic stress due to ongoing military actions within its borders. In current conditions, psychoemotional disorders in patients with somatic pathology are often underestimated, with physiological states being confused with pathological anxiety. This oversight can lead to ineffective treatment, worsening patient conditions, and negative prognoses. As a result, the diagnosis and treatment of anxiety syndrome, particularly in pregnant women with both obstetric and extragenital pathology under chronic stress, is a pressing issue in modern obstetrics. The purpose of this study was to assess the presence of anxiety syndrome in pregnant women of the Kharkiv region with obesity and gestational diabetes mellitus during martial law. Materials and methods. To achieve the objective of this study, 85 women aged 24 to 39 years were examined at 30–42 weeks of pregnancy. The main group consisted of 63 pregnant women with obesity and gestational diabetes mellitus, further divided into three clinical subgroups: the first group included 24 women with gestational diabetes mellitus, the second group comprised 16 women with pre-pregnancy obesity, and the third group consisted of 23 women with both gestational diabetes mellitus and obesity. The control group included 22 women without somatic or obstetric pathology. The GAD-7 questionnaire was used to assess the overall level of anxiety. Results and discussion. All participants answered the questionnaire with scores of 2–3 points, indicating significant anxiety levels, as total scores reached 14 points or higher. Notably, the average anxiety scores in the groups with gestational diabetes mellitus, obesity, and gestational diabetes mellitus with obesity were similar—16.5±2.3, 17.9±1.8, and 17.6±2.5, respectively— and were significantly higher than those of the control group, which averaged 4.4±2.6 (p < 0.05). Thus, all women in the main group (63 pregnant women) exhibited clear signs of anxiety, including irritability (95.2%), restlessness (79.4%), inability to relax (74.6%), and anticipation of dreadful events (66.0%). These symptoms were more pronounced in women with obesity compared to those with gestational diabetes mellitus without obesity. Conclusion. Under martial law conditions, pregnant women with comorbidity of gestational diabetes mellitus and obesity exhibit a significantly higher level of anxiety compared to women with a physiological pregnancy, although the latter also experience anxiety disorders, but to a lesser degree. Assessing anxiety disorders in pregnant women with gestational diabetes mellitus and obesity using the GAD-7 scale enables timely detection of these issues, even remotely. This facilitates appropriate referrals to specialists such as psychologists, psychotherapists, or psychiatrists, and allows for the early initiation of necessary therapy.
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