Pharmacotherapy of Post-Traumatic Stress Disorder

“…It was also studied the effect of valproat on tardive dyskinesia [116]. AEDs are also widely used to treat several psychiatric disorders including bipolar disorders, anxiety, schizophrenia, mood disorders, agitation and aggression in dementia, eating disorders, post-traumatic stress disorders and alcohol and cocaine dependence and withdrawal [103,105,107,110,[117][118][119][120][121]. Recently the evidence of the bidirectional relation between depression and epilepsy was published by Kanner [117].…”

Section: Aeds For Non-epileptic Cns Disordersmentioning

confidence: 98%

Recent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disorders

Dalkara

Karakurt²

2012

CTMC

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Major advances in antiepileptic drug therapy have taken place since 1950s. In the first period, several antiepileptic drugs (AEDs) such as phenobarbital, diphenylhydantoin, ethosuximide, carbamazepine, benzodiazepines and valproic acid were introduced to epilepsy treatment. After 1990 many new generation drugs (lamotrigine, topiramate, gabapentine, pregabaline, felbamate, lacosamide, levetiracetam etc.) have been developed. These novel AEDs have offered some advantages such as fewer side effects, fewer drug-drug interactions, and better pharmacokinetic properties. But pharmacoresistance and therapeutic failure in 20-25% of the patients remain the main reasons to continue efforts to find safer and more efficacious drugs and ultimate a treatment for this devastating disease. Several AEDs especially novel compounds have been found to be effective also in the treatment of several other neurologic and psychiatric disorders. Chemical diversity of the newer antiepileptic drugs as well as those currently in clinical development is another point that encourages medicinal chemists to study this subject. This review summarizes recent studies on the development of potential anticonvulsant compounds in different chemical structures, their structure-activity relationships and also therapeutic usages of AEDs other than epilepsy.

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“…The risk of suicide among those with PTSD is higher for people reporting nightmares than for those who do not 8. Accordingly, symptoms need to be recognized and treated appropriately if they are not to become persistent 9. In addition, patients with PTSD are at high risk of developing comorbid psychiatric disorders such as mood, anxiety, and substance abuse disorders.…”

Section: Objectivesmentioning

confidence: 99%

The effectiveness of cognitive behavioral therapy with respect to psychological symptoms and recovering autobiographical memory in patients suffering from post-traumatic stress disorder

Akbarian¹,

Bajoghli

Haghighi³

et al. 2015

NDT

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ObjectivesGiven the persistence of post-traumatic stress disorder (PTSD) and its major impact on everyday life, it is important to identify effective treatments. In additional to pharmacological treatments, psychotherapeutic treatments are also highly effective. The aim of the present study was to investigate, among a sample of patients suffering from PTSD, the influence of an additional cognitive behavioral therapy (CBT) intervention on their symptoms of PTSD, depression, and anxiety, and on autobiographical memory.MethodsA total of 40 patients suffering from PTSD (mean age: 31.64 years; 78.6% female patients) and under psychopharmacological treatment were randomly assigned to an intervention or control condition. The intervention consisted of ten group sessions (one 60–90 minute session per week) of CBT. At baseline and 10 weeks later, a series of self-rating and experts’-rating questionnaires were completed.ResultsOver time, symptoms of PTSD, depression, and anxiety decreased; however, greater improvement was observed in the experimental than the control condition. Likewise, as a general pattern of results, memory performance improved over time, though again this improvement was greater in the experimental condition.ConclusionCompared to a control condition, additional CBT improves the treatment of PTSD, with respect to both symptoms and autobiographical memory.

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Pharmacotherapy of Post-Traumatic Stress Disorder

Cited by 39 publications

References 93 publications

Pilot study of the effect of lipophilic vs. hydrophilic beta-adrenergic blockers being taken at time of intracardiac defibrillator discharge on subsequent PTSD symptoms

Pilot study of the effect of lipophilic vs. hydrophilic beta-adrenergic blockers being taken at time of intracardiac defibrillator discharge on subsequent PTSD symptoms

Recent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disorders

The effectiveness of cognitive behavioral therapy with respect to psychological symptoms and recovering autobiographical memory in patients suffering from post-traumatic stress disorder

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