Pharmacotherapy of psychiatric inpatients with adjustment disorder: current status and changes between 2000 and 2016

Pharmacotherapy of 1,044 inpatients with posttraumatic stress disorder: current status and trends in German-speaking countries

“…The mean number of psychotropics per patient with PTSD in this sample was 2.4 and therefore higher than in inpatients with adjustment disorder (2.1 per patient [ 21 ]) but lower than in inpatients with BPD (2.8 per patient [ 20 ]). The prescription rate in our sample was lower than in a large US veteran outpatient sample with PTSD (3.5 per patient [ 11 ]).…”

“…1 Time trends for prescription rates of a main groups of psychotropic drugs, b antidepressant drugs: selective serotonin reuptake inhibitors (SSRI), noradrenergic and specific serotonin reuptake inhibitors (NaSSA), selective serotonin noradrenaline reuptake inhibitors (SSNRI), tricyclic antidepressants (TCA) and "other antidepressants" and c antipsychotic drugs inpatients with PTSD may exhibit high symptom burden and higher rates of therapy-resistance that leads to psychiatric admission and which may partially explain a more frequent use of psychotropics. The mean number of psychotropics per patient with PTSD in this sample was 2.4 and therefore higher than in inpatients with adjustment disorder (2.1 per patient [21]) but lower than in inpatients with BPD (2.8 per patient [20]). The prescription rate in our sample was lower than in a large US veteran outpatient sample with PTSD (3.5 per patient [11]).…”

“…High prescription rates have been observed in inpatients with other psychiatric disorders like BPD (90% [ 20 ]) and adjustment disorder to a similar degree (81.2% [ 21 ]). The high overall prescription rate of psychotropic drugs may seem surprising as psychopharmacotherapy is not recommended as first-line treatment for PTSD.…”

“…Despite being not approved, SGAs are commonly used for patients with anxiety disorder and PTSD [ 24 , 25 ] with an increasing trend [ 26 ]. Similarly, increasing rates of the prescription of quetiapine have been reported for patients with adjustment disorder [ 21 ] or BPD [ 20 ]. Quetiapine is usually well-tolerated without having an addictive potential as compared to benzodiazepines [ 21 ].…”

“…Similarly, increasing rates of the prescription of quetiapine have been reported for patients with adjustment disorder [ 21 ] or BPD [ 20 ]. Quetiapine is usually well-tolerated without having an addictive potential as compared to benzodiazepines [ 21 ]. In addition to its sedative effect, quetiapine may prove potentially beneficial in the treatment of PTSD: in a placebo-controlled trial with 80 patients, Villarreal et al [ 27 ] found quetiapine monotherapy given over a period of 12 weeks an efficacious treatment, particularly for symptoms like re-experiencing, hyperarousal and insomnia.…”