Pharmacotherapy of Stress Urinary Incontinence

Castro-Díaz, David Manuel; Fumero, Sergio

doi:10.1007/978-1-84628-510-3_8

Cited by 4 publications

(8 citation statements)

References 37 publications

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“…TCAs are well established for use in treating major depression due to their inhibition of the presynaptic reuptake of serotonin (5HT) and norepinephrine (NE) according to Karch [38]. The most widely recognized TCA for the treatment of UI is imipramine, which has been successfully employed in treating nocturnal enuresis in children along with stress UI [41]. Researchers conducting animal investigations into the mechanisms underlying TCA efficacy in treating UI have focused on the anticholinergic properties of imipramine; yet, the exact mechanisms underlying its efficacy are still poorly understood [37, 41].…”

Section: Introductionmentioning

confidence: 99%

“…The most widely recognized TCA for the treatment of UI is imipramine, which has been successfully employed in treating nocturnal enuresis in children along with stress UI [41]. Researchers conducting animal investigations into the mechanisms underlying TCA efficacy in treating UI have focused on the anticholinergic properties of imipramine; yet, the exact mechanisms underlying its efficacy are still poorly understood [37, 41]. There is, however, considerable reason to believe that imipramine's effect on 5HT may also play a significant role.…”

Section: Introductionmentioning

confidence: 99%

“…Given that 5HT is known to produce an inhibitive effect on the commencement of micturition [40] by stimulating 5HT 2 receptors, which increase striated sphincter closure [42], it is difficult to tease apart the multifaceted modes of action in which imipramine elicits its effect on UI. What is known, however, is that there has been a lack of consistent randomized controlled studies on imipramine; as a result, at a recent International Consultation on Incontinence, imipramine was given a “D” recommendation grading due to the need for more empirical research [41]. …”

Section: Introductionmentioning

confidence: 99%

“…Animal research involving cats has demonstrated that 5HT can influence somatic bladder activity by inhibiting parasympathetic activity [41]. Research on both cats and rats has established that the facilitation of bladder activity could be initiated by administering the serotonergic neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT) [43, 44].…”

Section: Introductionmentioning

confidence: 99%

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Urinary Incontinence: Its Assessment and Relationship to Depression among Community-Dwelling Multiethnic Older Women

Laganá

Bloom

Ainsworth

2014

The Scientific World Journal

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Urinary Incontinence (UI) affects many older adults. Some of its deleterious consequences include stress, major depression, diminished quality of life, sexual dysfunction, and familial discord. Of the various mental health problems identified in the literature as being comorbid with UI, the most notable one continues to be depression. Despite a wealth of research contributions on this topic, the available literature is underrepresentative of ethnic minority older women. Culture has been shown to have a significant impact on a woman's perception of her own UI symptoms; this demonstrates the necessity for the recruitment of ethnically and culturally diverse samples when studying UI. In the present study, we determined the prevalence of UI among 140 community-dwelling, ethnically diverse older women (28.2%), discovered that our new UI screener is reliable, and did not find the UI-depression link to be significant. The clinical and research implications of our findings are discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Urinary Incontinence: Its Assessment and Relationship to Depression among Community-Dwelling Multiethnic Older Women

Laganá

Bloom

Ainsworth

2014

The Scientific World Journal

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“…A search for effective and well-tolerated drugs for treatment of SUI has demonstrated clinical efficiency of norepinephrine (NE) and/or serotonin reuptake inhibitors, such as duloxetine, in patients with SUI (2,5). The action of these drugs is considered to be associated with reuptake inhibition of serotonin and NE at the presynaptic terminal in Onuf's nucleus of the sacral spinal cord (17).…”

mentioning

confidence: 99%

Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats

Kaiho

Izumi

Chancellor

et al. 2007

American Journal of Physiology-Renal Physiology

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To clarify the role of noradrenergic pathways in preventing stress urinary incontinence (SUI) during sneezing, we investigated the effect of the norepinephrine reuptake inhibitor nisoxetine and alpha-adrenoceptor antagonists phentolamine (nonspecific blocker) and prazosin (alpha(1)-receptor-selective blocker) on the neurally evoked urethral continence reflex induced by sneezing in rats. The amplitude of urethral pressure responses during sneezing (A-URS), urethral baseline pressure (UBP) at the midurethra, and sneeze-induced leak point pressure (S-LPP) were measured in normal female adult rats and rats with SUI induced by vaginal distention (VD). In normal rats, intrathecal (it) phentolamine (0.02 nmol) and prazosin (0.02 nmol) decreased A-URS by 11.9 and 15.7%, respectively, without affecting UBP. In both normal and VD rats, intravenous (iv) application of nisoxetine (1 mg/kg) increased A-URS by 17.2 and 18.3% and UBP by 23.7 and 32.7%, respectively. Phentolamine or prazosin (both it) eliminated nisoxetine-induced increases in A-URS, but not the increases in UBP, which were, however, suppressed by iv phentolamine (5 mg/kg) or prazosin (1 mg/kg). Sneezing induced fluid leakage from the urethral orifice in VD rats, but not in normal rats. In VD rats, S-LPP was increased by 30.2% by iv nisoxetine. Application of phentolamine and prazosin (both it) decreased S-LPP by 15.7 and 20.6%, respectively, and nisoxetine induced increases in S-LPP to 13.2 and 12.3%, respectively. These results indicate that activation of the noradrenergic system by a norepinephrine reuptake inhibitor can prevent SUI via alpha(1-)adrenoceptors by enhancing the sneeze-induced active urethral closure mechanism at the spinal level and augmenting UBP at the periphery.

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Angiogenic gene modification of skeletal muscle cells to compensate for ageing‐induced decline in bioengineered functional muscle tissue

et al. 2008

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OBJECTIVE To explore the effects of ageing on the viability of bioengineered striated muscle tissue in vivo, and if this viability can be enhanced by concurrent neovascularization, as its utility for the treatment of stress urinary incontinence (SUI) might be reduced if muscle cells are derived from old patients. MATERIALS AND METHODS Myoblasts were obtained and expanded in culture from young (2 weeks), mature (3 months) and old (24 months) mice, and were engineered to express vascular endothelial growth factor (VEGF) to stimulate neovascularization. Myoblasts were injected subcutaneously into male nude mice and after 2 and 4 weeks, the engineered muscle tissues were harvested. RESULTS Bioengineered muscle tissues were formed in all groups, but the engineered muscles formed by myoblasts from old mice were smaller and less contractile. However, the bioengineered muscles expressing VEGF had a greater mass and better contractility in all age groups. CONCLUSION This pilot study showed that there was an age‐related decline in the size and function of bioengineered muscle; however, there was an improvement in volume and function when the muscle cells were expressing VEGF.

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Pharmacotherapy of Stress Urinary Incontinence

Cited by 4 publications

References 37 publications

Urinary Incontinence: Its Assessment and Relationship to Depression among Community-Dwelling Multiethnic Older Women

Urinary Incontinence: Its Assessment and Relationship to Depression among Community-Dwelling Multiethnic Older Women

Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats

Angiogenic gene modification of skeletal muscle cells to compensate for ageing‐induced decline in bioengineered functional muscle tissue

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