Pharmacovigilance in radiopharmaceuticals

Abstract

Indian Pharmacopoeia Commission is Committed for maintaining the standards of drugs including Radiopharmaceuticals (RPs) by publishing Indian Pharmacopoeia. These RPs are being used in India for diagnostic or therapeutic purpose. RPs though contain relatively small quantities of active ingredient and administered in small volumes could cause some adverse reactions to the patients. The objective of presenting this article is to introduce the system of adverse drug reaction reporting to the nuclear medicine fraternity who are dealing with RPs.

Boric acid in organic synthesis: scope and recent developments

“…Aza-Michael addition of aromatic amines to divinyl sulfone (18) and electron-deficient alkenes (20) has been accomplished in the presence of boric acid/glycerol in water under reflux to obtain the corresponding addition products in good to excellent yields without polymerization. The method can thus be used to produce Nsubstituted thiomorpholine-1,1-dioxides 19 and β-amino esters/ketones/nitriles 21 from compounds 18 and 20 respectively (Scheme 6).…”

“…Bisindolylmethanes and tetra-indolyl derivatives were synthesized by Kumar and his group by the condensation of indoles with mono-aldehydes 30 and di-aldehydes such as terephthalaldehyde, in a stirred mixture at room temperature using silica-supported boric acid to give bisindolylmethanes 31 and the tetraindole derivative 32 respectively (Scheme 11). 18…”

“…Thus, when tyramine 46 or 2-aminoethanol 47 were treated with acetic anhydride (1.1 equiv.) at 50 ⁰C in presence of H 3 BO 3 -SiO 2 , a highly chemoselective acetylation of amino groups takes place, and the products 48 and 49 were obtained in excellent yields (Scheme 20) 18.…”

The global perspective of pharmacovigilance in nuclear medicine practice

“…The Indian Pharmacopoeia Commission (IPC) has included 19 radiopharmaceuticals in IP-2014 and another 10 in the Addendum 2015. [ 28 ] In India, radiopharmaceuticals use is regulated under the provision of the Drugs and Cosmetics Act, 1940 and Rules 1945. [ 29 ] The suspected adverse events due to radiopharmaceuticals can be reported like that of any other drugs.…”

SiO2–H3BO3promoted solvent-free, green and sustainable synthesis of bioactive 1-substituted-1H-tetrazole analogues

“…A silica-supported boric acid (SiO 2 -H 3 BO 3 ) catalyst was prepared by employing standard procedures depicted in the literature (Scheme 1). 36 It has emerged as a promising heterogeneous solid acid catalyst in many organic transformations [36][37][38] Fig. 1 Drugs in the market with a tetrazole moiety.…”