Pharmacovigilance study in medicine department in a tertiary care hospital

Mishra, Ranjan; Jeevangi, Santosh Kumar; Vardhamane, Shrenik; Kumar, Sunil

doi:10.18203/2319-2003.ijbcp20164133

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…Thus the majority of the ADRs were evaluated as being probable. This was similar to the results of past studies 8,9,10 . 78% of cases recovered fully and 2.2% of the ADR patients died (Figure -3).…”

Section: Discussionsupporting

confidence: 93%

Causality Assessment and Outcome of Adverse Drug Reaction Related Hospitalization in a Tertiary Care Teaching Hospital

Mohapatra¹

2018

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Background: Adverse Drug Reactions (ADRs) are one of the leading causes of morbidity and mortality worldwide. They are important cause of hospitalization and rank fifth among all causes of death in developed countries. The present study was aimed to study the causality assessment and outcome of ADR related hospitalizations in the Medicine department of our tertiary care teaching hospital. Methods: A prospective, observational study was conducted over a period of 10 months and included all adult patients with suspected ADR admitted to the Department of Medicine. Each patient of ADR was assessed for causality using the WHO Probability Scale. Results: ADR related hospitalizations accounted for 0.24% of the total admissions to the Medicine department. The commonest ADR was hypoglycemia, followed by cutaneous drug reactions. Insulin and sulfonylureas were the most common suspected medications followed by antimicrobials. The most common predisposing factor was polytheapy. Causality assessment revealed that 36% of cases were certainly associated, 45% probably associated and 19% possibly associated with the respective suspected drugs. Death occurred in 2.2% of the ADR patients.

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Section: Discussionsupporting

confidence: 93%

Causality Assessment and Outcome of Adverse Drug Reaction Related Hospitalization in a Tertiary Care Teaching Hospital

Mohapatra¹

2018

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“…Poor reporting practice had also been observed in other study in Ethiopia 24 . Most of the physicians faced ADR with antibiotic (81.35%) NSAIDs (33.89%) and anticonvulsant (15.25%) and 44.06% physicians faced ADR were with skin, 30.50% with GIT and 22.03% physicians faced ADR with respiratory system involvement which more or less corresponds with other study 25 .…”

Section: Discussionsupporting

confidence: 61%

Current Status of Adverse Drug Reaction Reporting by the Physicians in A Medical College Hospital

Ata

Hoque

Mostafa

et al. 2021

Chatt Maa Shi Hosp Med Coll J

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Background: In order to improve the spontaneous Adverse Drug Reaction (ADR) reporting practice by the physicians, there is an obligatory need to investigate the current situation of ADR reporting by them. The study was conducted to observe the ADR reporting pattern among physicians in a tertiary medical college hospital. Materials and methods: This was a descriptive cross sectional study carried out in a tertiary medical college hospital during the study period of March 2020 to October 2020. Data were collected from 100 physicians working on different departments using self designed pretested questionnaire by convenient sampling technique. Results: Among the 100 respondents 70 provided response to questionnaire giving a response rate 70%. Most of the respondents (61.43%) had adequate knowledge on ADR reporting. A good number of respondents showed positive attitude but there is no practice of ADR reporting though most of the respondents (84.3%) had experienced it in last 1 year. Most of the respondents experienced ADR with antibiotic (81.35%), NSAIDs (33.89%) & anticonvulsants (15.25%) and maximum (44.06%) experienced ADR was with skin, 30.50% with GIT and 23.03% with respiratory system involvement. The cause of under reporting was mainly due to inaccessible ADR form, busy schedule, unaware of how and whom to report and lack of motivation to report. The respondents would be encouraged to report ADR if they were provided with simple & available reporting form, regular guideline & bulletin. Conclusion: There is an urgent need for educational training & seminar regarding our national online reporting system to emphasizing ADR reporting. Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 8-13

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“…[ 2 24 , 26 27 ] But Mishra et al . [ 28 ] observed single drug as the most common drug involved in ADRs, followed by multiple drugs. They have not provided explanation for this variation in their study.…”

Section: Discussionmentioning

confidence: 99%

“…[ 38 ] Although the exact mechanism behind NSAID-induced hypersensitivity reactions is not fully understood, it is proposed that NSAID-induced Cyclooxygenase blockade results in excessive prostaglandin E 2 production in the affected persons, which may be the reasons. [ 28 41 ]…”

Section: Discussionmentioning

confidence: 99%

Adverse drug reaction profile in Amravati region of India: A pharmacovigilance study

2020

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A BSTRACT Background: This pharmacovigilance study was conducted in Amravati region of central India to identify the nature and prevalence of adverse drug reactions, which will be helpful for better drug prescription practice and management of diseases. Materials and Methods: Adverse drug reaction reporting forms from April 2016 to March 2019, were collected from the pharmacovigilance center, which include details of demographics, investigations, concomitant drug history, and details of present complaints including reaction details, onset, recovery, drug information, hospitalization, management, and assessment. Results: A total of 19 cases were reported. Approximately 47.4% male and 52.6% female experienced the reactions with age-group ranging from 15 to 75 years. The most common adverse drug reactions were caused by antimicrobial agents (47.6%) followed by other group of drugs (37%) and nonsteroidal anti-inflammatory drugs (15.9%). Polypharmacy was the most common cause (31.6%) with the most common route being intravenous (42.1%). Skin reactions were the most common (84.2%). Antitubercular drugs were more commonly responsible for exfoliative lesions, whereas paracetamol and unknown drugs were responsible for multiple ulcerative lesions. Reactions to antitubercular drugs were considered as possible (15.8%), whereas with other drugs (63.2%), it was probable. Conclusion: It is a tip of the iceberg, which provides important demographic details in which adverse drug reactions were reported. Cutaneous reactions due to common drugs are responsible for hospitalization of the patients. There is an urgent need of training for health-care providers so that reporting can be improved and better picture can emerge.

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Pharmacovigilance study in medicine department in a tertiary care hospital

Cited by 4 publications

References 10 publications

Causality Assessment and Outcome of Adverse Drug Reaction Related Hospitalization in a Tertiary Care Teaching Hospital

Causality Assessment and Outcome of Adverse Drug Reaction Related Hospitalization in a Tertiary Care Teaching Hospital

Current Status of Adverse Drug Reaction Reporting by the Physicians in A Medical College Hospital

Adverse drug reaction profile in Amravati region of India: A pharmacovigilance study

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