Pharmacovigilance Study of Antiretroviral Therapy in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients at Antiretroviral Therapy Centre, Jabalpur

Bansal, Rajkumari; Daryani, K. K.; Singh, Ajit

doi:10.22159/ajpcr.2018.v11i9.26747

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…This is in correlation with the study conducted by Parmar because they found that HIV infected patients taking Efavirenz based HAART (TLE) had better clinical outcomes, higher survival rate, and increase in CD4 cell count after the HAART (p=0.001) compared to those taking Nevirapine based HAART (ZLN) 11 . In addition to efficacy, ADR's were found to be predominant with NVP based therapy 12 . However, a study conducted by Bhuvana and Hema shows that ZLN is the most commonly prescribed regimen which is not by this study 13 .…”

Section: Statistical Analysis and Interpretationmentioning

confidence: 99%

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2022

IJPSR

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To assess the risk factors, opportunistic infections (OI's), prescribing patterns along with ADRs, medication adherence, and quality of life (QoL) among HIV patients. Methods: This is an Ambi-directional cohort study conducted at the Government hospital, Bhimavaram, for 6 months from July 2019 to December 2019, including 201 HIV patients' data. The data were analyzed using GraphPad Prism 8.3.0. Descriptive statistics & paired t-test were employed to assess risk factors, OIs, prescribing patterns, and QoL, respectively. Results: Out of 201 patients. Heterosexuality (96%) was found to be a predominant risk factor in this study. Between type-1 and type 2 HIV patients, Tenofovir Disoproxil Fumarate/ Lamivudine & Efavirenz (TLE) and Tenofovir Disoproxil Fumarate/ Lamivudine/ Lopinavir/ Ritonavir (TL/ATV/r) were the first-line and second-line therapies respectively in type-1 patients; however, TL/LPV/r was reserved for type 2 individuals. Among 201 patients, 55 patients were reported with 60 ADR's and the predominant ADR was found to be rashes (36%). Approximately 76% were reported with a history of OI's, the most prevalent being TB (39%). Almost 94% of individuals were highly adherent to ART with the improvement in QoL after treatment. Conclusion: This study concluded that heterosexuality is the major risk factor and is effectively managed by TLE-based ART. It also reported rashes as the most common ADR and TB as the most prevalent OI. QoL in all domains has been improved after ART with greater adherence. INTRODUCTION:The global incidenceprevalence ratio of the human immunodeficiency virus (HIV) has declined from 11.2% in 2000 to QUICK RESPONSE CODE

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Section: Statistical Analysis and Interpretationmentioning

confidence: 99%

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2022

IJPSR

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Adverse drug reaction patterns of anti-retroviral drugs: A study in a tertiary care teaching Institute of north east India

ZOSANGPUII

Datta

Gunindro

et al. 2022

Asian J Pharm Clin Res

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Objective: The use of antiretroviral drugs is associated with significant safety concerns but there is still insufficient data about the toxicity profile of ART drugs especially in developing countries. Hence, this study was done to describe the severity and pattern of different types of adverse drug reactions that occurs with antiretroviral therapy.Method: A retrospective cross-sectional study was done at Pharmacovigilance centre RIMS utilizing data from January 2016 till December 2019.Result: A total of 190 cases reported during the study period were included in this study. Incidence was higher in females (109) as compared to males (81). The most common regimen responsible was TLE (69.5%) followed by ZLN (16.3%). Involvement of dermatological system (27.4%) was most common. The most common ADR associated with TLE was skin rash (28.3%) which was less severe as compared to the most common ADR associated with ZLN, which was anaemia (40.6%). On evaluation of WHO-UMC causality of ADRs, majority were found to be possible (78.2%).Conclusion: TLE regimen requires special focus as it was the most common regimen causing ADR but patients on ZLN regimen need to be closely monitored as they were found to cause more serious ADRs. A more active pharmacovigilance is needed for better understanding of toxicities related to ART.Key words: Adverse drug reactions, Pharmacovigilance, WHO-UMC criteria, Anti-retroviral therapy.

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The the Impact of Antiretroviral Therapy on Hemoglobin Levels of Hiv/Aids Patients at Merpati Clinic, Wangaya Hospital, Denpasar, Bali, Indonesia

Darmada¹,

Suryana²

2020

Int J Pharm Pharm Sci

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Objective: Anemia is responsible for poor outcomes in HIV/AIDS patients. It’s related to disease progression, morbidity, and mortality. Antiretroviral therapy (ART) agent, zidovudine (ZDV) is also known to trigger anemia in the early initiation. However, studies found improved hemoglobin (Hb) levels of HIV/AIDS patients several months after ART routinely taken. This study aims to find the impact and correlation of ART on the hemoglobin level of HIV/AIDS patients. Methods: A retrospective cohort study was done at Merpati Clinic, Wangaya Hospital, Denpasar-Bali, Indonesia. Data were collected from medical records and laboratory results. A total sample of 64 HIV/AIDS patients with at least 6 mo on ART was included in this study. Results: Anemia was found in 34 (53.1%) of patients before ART initiation. After taking ART for 6 mo, we observed a significant improvement in patients’ hemoglobin levels, 48 (75%) shows increased hemoglobin levels. The paired t-test revealed a correlation between ART and Hb level (p<0.001). Fourteen (43.8%) patient taking ZDV shows no improvement, even declining of Hb level. Chi-square analysis performed with p = 0.001 to ZDV and lower or no improvement of hemoglobin level. Both results considered statistically significant (p-value less than 0.05) with a confidence interval (CI) of 95%. Relative risk (RR) of no improvement or decline in Hb level is 7 folds higher in the ZDV group than the non-ZDV group. Conclusion: This study concludes that ART affects hemoglobin levels in HIV/AIDS patients. Zidovudine regimen is more prone to lower or no increase of Hb.

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Pharmacovigilance Study of Antiretroviral Therapy in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients at Antiretroviral Therapy Centre, Jabalpur

Cited by 3 publications

References 12 publications

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Adverse drug reaction patterns of anti-retroviral drugs: A study in a tertiary care teaching Institute of north east India

The the Impact of Antiretroviral Therapy on Hemoglobin Levels of Hiv/Aids Patients at Merpati Clinic, Wangaya Hospital, Denpasar, Bali, Indonesia

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