This chapter delves into the holistic practice of aromatherapy, which harnesses the therapeutic potential of aromatic compounds in essential oils derived from medicinal plants to support physical, emotional, and mental health. The chapter traces the historical roots of aromatherapy, emphasizing its revered role in ancient civilizations, where aromatic substances were utilized for their healing properties. Examining aromatherapy through chemical, biochemical, and pharmacological lenses underscores the diverse therapeutic applications of essential oils. A focal point of the chapter is the introduction of the aroma wheel, a tool that categorizes and elucidates the intricate scents of essential oils, aiding in their practical application. The chapter also explores the extensive trade of spices and aromatic substances—such as musk, ambergris, camphor, and sandalwood—during the medieval period, particularly in the East and Spain. A notable figure in this historical narrative is the Spanish physician and aromatherapist Albucasis, who extensively addressed the use of aromatherapy in the nineteenth book of his influential work, Kitab al-Tasrif. By offering a comprehensive overview of the historical, chemical, and therapeutic dimensions of aromatherapy, this chapter serves as a valuable resource for researchers and practitioners in natural medicine, illustrating how the power of scent can significantly enhance health and well-being.