“…Second, for disease management to demonstrate cost savings or cost-effectiveness of compliance programs, they must be able to identify avoidable adverse health outcomes, such as hospital admissions and emergency room visits, with adequate pharmacy and medical claims data at their disposal. 33 Therefore, a suggestion for evaluating the costsaving potential of a compliance program would be in terms of inpatient hospitalization days and emergency department visits, because these measures enable ''number needed to decrease'' analysis. 37 Further, ideally, to evaluate the costeffectiveness potential of a compliance program entails measurement of incremental cost-effectiveness, that is, comparing the costs and effectiveness of a compliance program to one that does not target compliance.…”