Pharmakokinetik von Furosemid unter Hämodialyse

Dialysis and iodinated contrast media

“…The decrease of the serum level caused by renal elimination leads to a rediffusion of the contrast medium out of the tissue and back into the intravascular space, 3 and the decrease in plasma concentration follows a two-part exponential function. [4][5][6][7][8] In normal subjects and in subjects with mild, moderate, and severe renal impairment, the plasma concentration of the low osmolar contrast medium iomeprol declines biexponentially after intravenous administration. 8 Comparison of the fractions of the area under curve for each phase and comparison of the volume terms indicate that the first phase can be regarded as the distribution phase and the terminal phase as the elimination phase.…”