Pharmakologische Untersuchungen von Kamillen–Inhaltsstoffen – I. Zur Pharmakologie des (–)–α–Bisabolols und der Bisabololoxide (Übersicht)

Isaac, O.

doi:10.1055/s-0028-1097193

Cited by 49 publications

(9 citation statements)

References 4 publications

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“…The oil contains up to 20% polyynes. The principal components of the essential oil extracted from the flowers are (E)-β-farnesene (4.9–8.1%), terpene alcohol (farnesol), chamazulene (2.3–10.9%), α-bisabolol (4.8–11.3%), and α-bisabolol oxides A (25.5–28.7%) and α-bisabolol oxides B (12.2–30.9%),[3380–84] which are known for their antiinflammatory,[278586] antiseptic,[87] antiplogistic,[8188] and spasmolytic[89] properties. Among the various major constituents, α-bisabolol and chamazulene have been reported to be more useful than others.…”

Section: Chamomile (M Chamomilla) As a Source Of Natural Productsmentioning

confidence: 99%

“…[91] It has also been reported to promote epithelization and granulation, and to produce a pronounced and antiphlogistic effect on paw carrageenin edema and cotton pellet granuloma of the rat. [81] Similarly, it is recommended that, if chamomile extracts were to be used for their antiphlogistic effects then plants rich in bisabolol and chamazulene should be chosen. [8892] Also, because of the antiinflammatory properties of bisabolol, it is recommended in cosmetic preparations.…”

Section: Chamomile (M Chamomilla) As a Source Of Natural Productsmentioning

confidence: 99%

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Chamomile (Matricaria chamomilla L.): An overview

Singh¹,

Khanam²,

Misra³

et al. 2011

Phcog Rev

507

311

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Chamomile (Matricaria chamomilla L.) is a well-known medicinal plant species from the Asteraceae family often referred to as the “star among medicinal species.” Nowadays it is a highly favored and much used medicinal plant in folk and traditional medicine. Its multitherapeutic, cosmetic, and nutritional values have been established through years of traditional and scientific use and research. Chamomile has an established domestic (Indian) and international market, which is increasing day by day. The plant available in the market many a times is adulterated and substituted by close relatives of chamomile. This article briefly reviews the medicinal uses along with botany and cultivation techniques. Since chamomile is a rich source of natural products, details on chemical constituents of essential oil and plant parts as well as their pharmacological properties are included. Furthermore, particular emphasis is given to the biochemistry, biotechnology, market demand, and trade of the plant. This is an attempt to compile and document information on different aspects of chamomile and highlight the need for research and development.

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Section: Chamomile (M Chamomilla) As a Source Of Natural Productsmentioning

confidence: 99%

Section: Chamomile (M Chamomilla) As a Source Of Natural Productsmentioning

confidence: 99%

Chamomile (Matricaria chamomilla L.): An overview

Singh¹,

Khanam²,

Misra³

et al. 2011

Phcog Rev

507

311

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“…The herbal preparation combines the anti-inflammatory, antiphlogistic, and antibacterial potential of Myrrh resin, Commiphora molmol [11]–[14], and chamomile dry extract of chamomile flowers [15]–[22] with the antibacterial, astringent, and absorptive potential of coffee charcoal [23].…”

Section: Discussionmentioning

confidence: 99%

“…Myrrh resin, Commiphora molmol , with its main ingredients furanose sesquiterpene, diterpenoids, and volatile acids, exerts a broad spectrum of activity, including antiinflammatory, antiphlogistic, antioxidant, antibacterial, and astringent potentials [11]–[14]. Chamomile dry extract of chamomile flowers, with its main ingredients volatile acids, flavonglycosides, and hydroxycoumarins, exerts anti-inflammatory and antiphlogistic effects and has antibacterial, spasmolytic, and ulcer protective potentials [15]–[22]. In addition, coffee charcoal has antibacterial, astringent, and absorptive potentials [23].…”

Section: Introductionmentioning

confidence: 99%

Distinct Kinetics in the Frequency of Peripheral CD4+ T Cells in Patients with Ulcerative Colitis Experiencing a Flare during Treatment with Mesalazine or with a Herbal Preparation of Myrrh, Chamomile, and Coffee Charcoal

et al. 2014

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BackgroundWe found the first evidence of the efficacy of a herbal treatment with myrrh, dry extract of chamomile flowers, and coffee charcoal for ulcerative colitis (UC). However, the impact of the herbal treatment on the CD4+ T-cell compartment, which is essential for both the induction of UC and the maintenance of tolerance in the gut, is not well understood.AimTo analyze the frequency and functional phenotype of CD4+ T cells and of immune-suppressive CD4+CD25high regulatory T cells (Tregs) in healthy control subjects, patients with UC in remission, and patients with clinical flare of UC.MethodsPatients in clinical remission were treated with either mesalazine or the herbal preparation for 12 months. The frequencies of whole CD4+ T cells, CD4+CD25med effector T cells, and Tregs and the expression of Foxp3 within the CD4+CD25hig Tregs were determined by flow cytometry at 6 time points. We determined the suppressive capability of Tregs from healthy control subjects and from patients in remission or clinical flare.ResultsA total of 79 patients (42 women, 37 men; mean age, 48.5 years; 38 with clinical flare) and 5 healthy control subjects were included in the study. At baseline the frequencies of whole CD4+ T cells, CD4+CD25med effector cells, and Tregs did not differ between the two treatment groups and the healthy control subjects. In addition, patients with UC in sustained clinical remission showed no alteration from baseline after 1, 3, 6, 9, or 12 months of either treatment. In contrast, CD4+ T cells, CD4+CD25medeffector T cells, and Tregs demonstrated distinctly different patterns at time points pre-flare and flare. The mesalazine group showed a continuous but not statistically significant increase from baseline to pre-flare and flare (p = ns). In the herbal treatment group, however, the percentage of the CD4+ T cells was lower at pre-flare than at baseline. This decrease was completely reversed after flare, when a significant increase was seen (CD4+CD25med pre-flare/flare p = 0.0461; CD4+CD25high baseline/flare p = 0.0269 and pre-flare/flare p = 0.0032). In contrast, no changes in the expression of Foxp3 cells were detected within the subsets of CD4+CD25high regulatory T cells. Of note, no alterations were detected in the suppressive capability of CD4+CD25high regulatory T cells isolated from the peripheral blood of healthy donors, from patients in remission, or from patients with clinical flare.ConclusionsIn patients with UC experiencing acute flare, the CD4+ T compartment demonstrates a distinctly different pattern during treatment with myrrh, chamomile extract, and coffee charcoal than during treatment with mesalazine. These findings suggest an active repopulation of regulatory T cells during active disease.Trial RegistrationEU Clinical Trials Register 2007-007928-18/DE

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“…Bisabolool omab gvaiasuleeniga võrreldavat põletikuvastast toimet (Janku & Zita 1954), olles seejuures vähem toksiline kui gvaiasuleen, hamasuleen (Jakovlev & Schlichtegroll 1969) ja sünteetilised põletikuvastase toimega ained (Isaac 1975). (-)-Bisabolool on ligikaudu kaks korda tugevama põletikuvastase toimega kui (+)-bisabolool ja sellest tulenevalt on sünteetilise ratsemaatilise bisabolooli põletikuvastane toime kaks korda nõrgem kui (-)-bisaboloolil (Isaac 1975(Isaac , 1979Jakovlev 1975), bisabolooloksiididel A ja B ning bisaboloonoksiidil (Jakovlev & Isaac & Thiemer & Kunde 1979). Bisabolool takistab indometatsiini, stressi või piiritusega esile kutsutava haavandi tekkimist, kiirendades keemiliselt või termiliselt tekitatud haavandi paranemist (Szelenyi & Isaac & Thiemer 1979).…”

Section: Eesti Etnofarmakognoosia Elujõust Kummelite Näitelunclassified

Eesti etnofarmakognoosia elujõust kummelite näitel

Raal¹,

Arak²

2006

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Teesid: Uute ravimtaimede avastamisel ja ammu tuntud droogide kasutusalade laiendamisel on etnofarmakognoosia farmaatsiateaduse igati tunnustatud ja nüüdisaegne suund. Käesolevas artiklis analüüsitakse eesti etnofarmakognoosia elujõulisust kummelite kui populaarseimate ravimtaimede näitel. Rahvameditsiinilise andmestiku läbitöötamine on võimaldanud siinkirjutajatel püstitada hüpoteesid, mille kohaselt võiks lõhnava kummeli ja teekummeli toimeid pidada samaväärseteks ning kasutada lõhnava kummeli ürti teekummeli õisikute asendajana. Kirjutises refereeritud farmakognostiliste, fütokeemiliste ja farmakoloogiliste uuringute andmed on esivanemate kogemusi igati kinnitanud. See annab alust ja julgust lähtuda edasiste farmatseutiliste uuringute planeerimisel etnofarmakognoosiast ka teiste ravimtaimede puhul.

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Pharmakologische Untersuchungen von Kamillen–Inhaltsstoffen – I. Zur Pharmakologie des (–)–α–Bisabolols und der Bisabololoxide (Übersicht)

Cited by 49 publications

References 4 publications

Chamomile (Matricaria chamomilla L.): An overview

Chamomile (Matricaria chamomilla L.): An overview

Distinct Kinetics in the Frequency of Peripheral CD4+ T Cells in Patients with Ulcerative Colitis Experiencing a Flare during Treatment with Mesalazine or with a Herbal Preparation of Myrrh, Chamomile, and Coffee Charcoal

Eesti etnofarmakognoosia elujõust kummelite näitel

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