Pharmakologische Untersuchungen von Kamillen-Inhaltsstoffen

U, Achterrath-Tuckermann; Kunde, R.; Flaskamp, Elmar; Isaac, O.; Thiemer, K

doi:10.1055/s-2008-1074901

Cited by 97 publications

(27 citation statements)

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“…In this respect, it is interesting to note that even the low CEO dose tested reduced the SCE formed by DAU, particularly because this amount of oil is consumed in 10 to 12 cups of chamomile tea, a quantity similar to the suggested daily consumption of green tea for reducing the incidence of cancer [21]. With regard to the protection produced by CEO, the effect could have been aided by an easy crossing of the mixture through the testicular barrier resulting from the liposoluble components of the oil [22]. …”

Section: Discussionmentioning

confidence: 99%

Antigenotoxic Effect of Chamomilla recutita (L.) Rauschert Essential Oil in Mouse Spermatogonial Cells, and Determination of Its Antioxidant Capacity in Vitro

Hernández-Ceruelos¹,

Madrigal-Santillán²,

Morales-González³

et al. 2010

IJMS

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Chamomilla recutita (L.) Rauschert (Asteraceae), popularly known as chamomile, is a plant used in traditional medicine for various therapeutic purposes. Chamomile essential oil (CEO) is particularly known to inhibit the genotoxic damage produced by mutagens in mice somatic cells. The aim of this research was to determine the inhibitory potential of CEO on the genotoxic damage produced by daunorubicin (DAU) in mice germ cells. We evaluated the effect of 5, 50, and 500 mg/kg of essential oil on the rate of sister chromatid exchange (SCE) induced in spermatogonia by 10 mg/kg of the mutagen. We found no genotoxicity of CEO, but detected an inhibition of SCE after the damage induced by DAU; from the lowest to the highest dose of CEO we found an inhibition of 47.5%, 61.9%, and 93.5%, respectively. As a possible mechanism of action, the antioxidant capacity of CEO was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method and ferric thiocyanate assays. In the first test we observed a moderate scavenging potential of the oil; nevertheless, the second assay showed an antioxidant capacity similar to that observed with vitamin E. In conclusion, we found that CEO is an efficient chemoprotective agent against the damage induced by DAU in the precursor cells of the germinal line of mice, and that its antioxidant capacity may induce this effect.

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Section: Discussionmentioning

confidence: 99%

Antigenotoxic Effect of Chamomilla recutita (L.) Rauschert Essential Oil in Mouse Spermatogonial Cells, and Determination of Its Antioxidant Capacity in Vitro

Hernández-Ceruelos¹,

Madrigal-Santillán²,

Morales-González³

et al. 2010

IJMS

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“…The oil contains up to 20% polyynes. The principal components of the essential oil extracted from the flowers are (E)-β-farnesene (4.9–8.1%), terpene alcohol (farnesol), chamazulene (2.3–10.9%), α-bisabolol (4.8–11.3%), and α-bisabolol oxides A (25.5–28.7%) and α-bisabolol oxides B (12.2–30.9%),[3380–84] which are known for their antiinflammatory,[278586] antiseptic,[87] antiplogistic,[8188] and spasmolytic[89] properties. Among the various major constituents, α-bisabolol and chamazulene have been reported to be more useful than others.…”

Section: Chamomile (M Chamomilla) As a Source Of Natural Productsmentioning

confidence: 99%

Chamomile (Matricaria chamomilla L.): An overview

Singh¹,

Khanam²,

Misra³

et al. 2011

Phcog Rev

507

311

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Chamomile (Matricaria chamomilla L.) is a well-known medicinal plant species from the Asteraceae family often referred to as the “star among medicinal species.” Nowadays it is a highly favored and much used medicinal plant in folk and traditional medicine. Its multitherapeutic, cosmetic, and nutritional values have been established through years of traditional and scientific use and research. Chamomile has an established domestic (Indian) and international market, which is increasing day by day. The plant available in the market many a times is adulterated and substituted by close relatives of chamomile. This article briefly reviews the medicinal uses along with botany and cultivation techniques. Since chamomile is a rich source of natural products, details on chemical constituents of essential oil and plant parts as well as their pharmacological properties are included. Furthermore, particular emphasis is given to the biochemistry, biotechnology, market demand, and trade of the plant. This is an attempt to compile and document information on different aspects of chamomile and highlight the need for research and development.

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“…1), but also bisabololoxide A and B play a role (Jakovlev et al, 1983). Spasmolytical effects are attributed to apigenin and bisabololoxides (Achterrath-Tuckermann et al, 1980) and wound healing properties to chamazulene, apigenin and (-)α-bisabolol (Glowania et al, 1987). In addition, the chamomile oil has an antibacterial effect on Gram-positive germs and a fungicidal effect on Candida albicans when used in concentrations of more than 0.025% (Szalontai et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Biologically Active Essential Oil Components of Chamomiles in Hungary (In Vivo - In Vitro)

et al. 2003

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We studied the essential oil production of cultivated (BK-2, Degumil) and wild chamomile populations of 4 typical chamomile-rich regions of Hungary. We examined the essential oil composition of flowers, herbs (stem plus leaves) and roots using GC and GC/MS methods. Among cultivated species, the Hungarian BK-2 contains more chamazulene in its essential oil than the German Degumil type, which is mainly cultivated for its α-bisabolol. Both components have important antiinflammatory activities. Wild populations can be easily distinguished from cultivated ones by their high amount of bisaboloides, particularly the flower of Szabadkígyós wild type, which contained on average 48 % of the biologically active (-)-α-bisabolol. The regional wild chamomile samples mentioned above have already been examined previously in our Institute. We found it interesting to compare the content of biologically active components, at the same conditions, of presently promising populations with the results obtained 20 years ago from the same species. While the content of the essential oil of rural Szabadkígyós wild type remained unchanged, there was a trend of the essential oil components towards the therapeutically important compounds. The amount of (-)-α-bisabolol in Szabadkígyós mounted up to a 3-fold increase and we measured a doublefold increase of chamazulene content in BK-2 compared with samples 20 years ago. We can conclude that although a change was observed in the essential oil content and also in the proportion of different components, the fundamental characteristics of the oils remained the same. To keep the genom of Szabadkígyós wild type having high (-)-α-bisabolol content, we used biotechnological methods. The sterile roots of organised culture contained also β-eudesmol, wich was firstly identified from the intact roots by us. Our gas chromatographical and mass-spectroscopical studies showed that sterile chamomile cultures generated the most important terpenoid and polyin compounds characteristic of the mother plant. We identified berkheyaradulene, α-selinene, geranyl-isovalerate and cedrol as new components in these sterile cultures.

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Pharmakologische Untersuchungen von Kamillen-Inhaltsstoffen

Abstract: Chamomile extracts are used therapeutically for their antiinflammatory effect and also for their spasmolytic activity.

Cited by 97 publications

References 0 publications

Antigenotoxic Effect of Chamomilla recutita (L.) Rauschert Essential Oil in Mouse Spermatogonial Cells, and Determination of Its Antioxidant Capacity in Vitro

Antigenotoxic Effect of Chamomilla recutita (L.) Rauschert Essential Oil in Mouse Spermatogonial Cells, and Determination of Its Antioxidant Capacity in Vitro

Chamomile (Matricaria chamomilla L.): An overview

Analysis of Biologically Active Essential Oil Components of Chamomiles in Hungary (In Vivo - In Vitro)

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