Pharmazeutisch wichtige Naturstoffe im Blickpunkt

Rüċker, G.

doi:10.1002/pauz.19940230408

Cited by 3 publications

(2 citation statements)

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“…From these works (Falkenberg, 1991;Marek, 1994;Heinzmann, 1996;Rücker et al, 1996) some new peroxides were isolated. Some of the isolated peroxides were also tested for antimalarial activity, semi-synthesized and derivatized (Rücker, 1994). The compound with most promising activity was 1 (bisabolene-1,4-endoperoxide=1,4-epidioxy-bisabolan-2,12-diene) (Figure 1), for which in vitro an IC 50 0.05 was observed, in comparison with the value 0.005 for artemisinine as reference compound (Heinzmann, 1996;.…”

Section: Resultsmentioning

confidence: 99%

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Screening of brazilian plants for the presence of peroxides

Schenkel¹,

Rüċker²,

Manns³

et al. 2002

Rev. Bras. Cienc. Farm.

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Uniterms:• Peroxides• Antimalarial activity• Asteraceae INTRODUCTIONThe occurrence of natural products which contain a peroxide group has been known since 1911, when ascaridole was isolated from the essential oil of Chenopodium ambrosioides (Chenopodiaceae). This oil was utilized as anthelmintic and ascaridole was identified as responsible for its activity (Gessner, 1953;Hope, 1958). In the following decades, compounds with a similar structure were not isolated; peroxides were considered to be too unstable and ascaridole was thought to be an exception.In the meantime, as much as 320 peroxides have been isolated from natural material (Casteel, 1992). They occur mainly as terpene derivatives, although cumarine, fatty acids and alkaloids peroxides derivatives have also been isolated. Beside plants, many species of fungi and marine organisms produce metabolites containing a peroxide group. The peroxide function has been detected in different classes of natural compounds that are mentioned in Table I, based on the review published by Casteel (1992). The occurrence in vascular plant families according the literature published until 1999 is summarized by Table II. Many biological activities were described for the peroxides. They show ichthyotoxic and antimicrobial activity, fungicide, anthelmintic and cytotoxic activity. At the moment, the most important activity exhibited by peroxides is the antimalarial activity (Vennerstrom, Easton, 1988;Rücker, 1994). The prevention and cure of malaria depends on a limited number of drugs. Resistance of the malaria parasites Plasmodium ssp. to drugs such as quinine (and more lately chloroquine) occurs with increasing frequency and emphasize the necessity to develop new agents for malaria chemotherapy (Kirby, 1996). Quinghaosu (artemisinin), a sesquiterpene isolated from Artemisia annua, is the best known plant derivative as an antimalarial drug after quinine (Klayman, 1985). Another sesquiterpene peroxide, named yingzhaosu, was isolated from Artabotrys uncinatus (Annonaceae) and also possesses a significant antimalarial activity. Both compounds contain an endoperoxid group, which is responsible for their activity (Klayman, 1985) and have opened a new chapter in the chemotherapy of malaria. The majority of drugs active against malaria are in fact derived from natural products or from structures suggested by natural products prototypes, but, as a source of novel drugs, plants remain largely understudied (Kirby, 1996). Falkenberg et al. 192 Herewith we report the screening for detection of peroxides in extracts from higher plants from the states of Rio Grande do Sul and Santa Catarina, Brazil, based on Huber & Fröhlke's chromatographic test. The screening was developed to select promising plants for detailed investigation, aiming the isolation and structure elucidation of new peroxides. Fresh plant material (10-20 g) was crushed and extracted with CH 2 Cl 2 or CHCl 3 (10-20 mL) previously tested for peroxides. The extraction procedures were performed at the same day of the plant c...

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Section: Resultsmentioning

confidence: 99%

“…They show ichthyotoxic and antimicrobial activity, fungicide, anthelmintic and cytotoxic activity. At the moment, the most important activity exhibited by peroxides is the antimalarial activity (Vennerstrom, Easton, 1988;Rücker, 1994). The prevention and cure of malaria depends on a limited number of drugs.…”

Section: Introductionmentioning

confidence: 99%