Pharming: Joint Clonal Tree Reconstruction of SNV and CNA Evolution from Single-cell DNA Sequencing of Tumors
Leah L. Weber,
Anna Hart,
Idoia Ochoa
et al.
Abstract:Cancer arises through an evolutionary process in which somatic mutations, including single nucleotide variants (SNVs) and copy number aberrations (CNAs), drive the development of a malignant, heterogeneous tumor. Reconstructing this evolutionary history from sequencing data is critical for understanding the order in which mutations are acquired and the dynamic interplay between different types of alterations. Advances in modern whole genome single-cell sequencing now enable the accurate inference of copy numbe… Show more
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