2015
DOI: 10.1038/ncomms7667
|View full text |Cite
|
Sign up to set email alerts
|

Pharyngeal sense organs drive robust sugar consumption in Drosophila

Abstract: The fly pharyngeal sense organs lie at the transition between external and internal nutrient sensing mechanisms. Here, we investigate the function of pharyngeal sweet gustatory receptor neurons (GRNs), demonstrating that they express a subset of the nine previously identified sweet receptors and respond to stimulation with a panel of sweet compounds. We show that pox-neuro (poxn) mutants lacking taste function in the legs and labial palps have intact pharyngeal sweet taste, which is both necessary and sufficie… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

10
119
0

Year Published

2015
2015
2019
2019

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 79 publications
(129 citation statements)
references
References 45 publications
10
119
0
Order By: Relevance
“…In a previous study, we described neurons in the LSO and VCSO that co-express multiple Grs belonging to the sweet clade (LeDue et al, 2015). However, sweet neurons account for a small fraction (4 of 24) of pharyngeal gustatory receptor neurons (GRNs).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In a previous study, we described neurons in the LSO and VCSO that co-express multiple Grs belonging to the sweet clade (LeDue et al, 2015). However, sweet neurons account for a small fraction (4 of 24) of pharyngeal gustatory receptor neurons (GRNs).…”
Section: Resultsmentioning
confidence: 99%
“…A number of Gr - and Ir-GAL4 drivers are also shown to label pharyngeal organs (Kwon et al, 2014, Koh et al, 2014), however only a few, including Gr43a and members of sweet Gr clade, Gr2a , Ir60b , and TrpA1 , have been mapped to specific taste neurons (LeDue et al, 2015, Kang et al, 2010, Miyamoto et al, 2012, Kim et al, 2017, Joseph et al, 2017). …”
Section: Introductionmentioning
confidence: 99%
“…The sequence of events in feeding is generally that a fly encounters tastants with gustatory receptors on its legs, stops walking, pivots toward the stimulus, extends its proboscis, and starts feeding (Dethier 1976). Taste receptors inside the pharynx provide positive feedback to sustain ingestion (LeDue et al 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Gustatory system plays essential roles in taste sensing and food picking (Marella et al, 2006;Stafford et al, 2012). To examine whether the food preference switch we observed is dependent on taste-sensing pathway, we utilized 'taste-deficient' pox-neuro mutant (poxn) flies (Boll and Noll, 2002), which lack peripheral taste (LeDue et al, 2015) and have no proboscis extension response to sugar (Dus et al, 2011). Females of the poxn mutant showed decreased PI compared to WT in the normal feeding condition (Fig.…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 93%