Pharyngeal swallowing mechanics associated with upper esophageal sphincter pressure wave

May, Nelson H.; Davidson, Kate; Pearson, William G.; O’Rourke, Ashli

doi:10.1002/hed.26029

Cited by 15 publications

(14 citation statements)

References 29 publications

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“…This suggests that pre-swallow UES basal pressure may be influenced by preparatory central and possible volitional factors. In general, the UES pre-swallow contraction is thought to assist in the creation of negative pressures within the proximal esophagus which, upon UES opening, causes a bolus suction effect that facilitates bolus transfer into the esophagus (18,29,43). This suction effect is associated with negative nadir UES relaxation pressures, a biomechanical feature which was apparent in our participants, particularly during smaller volume swallows.…”

Section: Pharyngeal Ues and Proximal Esophageal Contractility Measuresmentioning

confidence: 76%

“…The oro-pharyngeal swallow response requires complex neuro-regulation (10,13,19,29,32,41,46,58). During volitional swallowing, bolus characteristics such as volume, taste, viscosity and temperature are detected and relayed to the sensory cortex, and brainstem (19).These sensory inputs enable adaptation of the swallow system for optimal bolus transfer from the oral cavity to the esophagus.…”

Section: Introductionmentioning

confidence: 99%

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Modulation of pharyngeal swallowing by bolus volume and viscosity

Ferris

Doeltgen

Cock

et al. 2021

American Journal of Physiology-Gastrointestinal and Liver Physi

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Background: Oro-pharyngeal swallowing involves complex neuromodulation to accommodate changing bolus characteristics. The pressure events during deglutitive pharyngeal reconfiguration and bolus flow can be assessed quantitatively using high-resolution pharyngeal manometry (HRPM) with impedance. Methods: An 8 French solid-state unidirectional catheter (32 pressure sensors, 16 impedance segments) was used to acquire triplicate swallows of 3- to 20- mls across 3 viscosity levels using a Standardized Bolus Medium (SBMkit) product (Trisco Pty Ltd, Australia). An online platform www.swallowgateway.com (Flinders University, South Australia) was used to semi -automate swallow analysis. Results: 50 healthy adults (29 female, 21 male, mean age 46 years) were studied. Hypopharyngeal intrabolus pressure, upper esophageal sphincter (UES) maximum admittance, UES relaxation pressure and UES relaxation time revealed the most significant modulation effects to bolus volume and viscosity. Pharyngeal contractility and UES post swallow pressures elevated as bolus volumes increased. Bolus viscosity augmented UES preopening pressure only. Conclusion: Describing swallow modulatory effects with quantitative methods in line with a core outcome set of metrics, and a unified analysis system for broad reference contributes to diagnostic frameworks for oropharyngeal dysphagia.

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Section: Pharyngeal Ues and Proximal Esophageal Contractility Measuresmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Modulation of pharyngeal swallowing by bolus volume and viscosity

Ferris

Doeltgen

Cock

et al. 2021

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

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“…The present study is clinically relevant, because it provides useful information on the UES opening during swallowing. In general, the UES opening has been considered as a passive event, because it occurs as a result of the elevation of the hyolaryngeal complex and of the relaxation of the cricopharyngeal part of the inferior constrictor [2,[7][8][9][10][11]. Our findings revealed that the palatopharyngeus spread across the inner surface of the cricopharyngeal part of the inferior constrictor, and it is connected to the cricopharyngeal part of the inferior constrictor thorough a dense connective tissue (Fig.…”

Section: Discussionmentioning

confidence: 69%

“…The opening of the upper esophageal sphincter (UES), which is located on the cricopharyngeal part of the inferior constrictor and the uppermost part of the esophagus [1][2][3][4], is one of the essential events required for proper swallowing [5,6]. In general, the UES opening occurs as a result of the elevation of the hyolaryngeal complex and the relaxation of the cricopharyngeal part of the inferior constrictor [2,[7][8][9][10][11]. Therefore, the mechanism of the UES opening has been considered a passive event, and a few studies have focused on whether any anatomical structures directly act on the UES opening.…”

Section: Introductionmentioning

confidence: 99%

“…The palatopharyngeus is one of the essential muscles required in proper swallowing, because it contributes to its various events, such as the movement of the soft palate, the shortening of the pharynx, and the elevation of the hyolaryngeal complex [3,7,8,[12][13][14]. The evidence of these contributions has been anatomically explained based on its attachments to the soft palate, the pharyngeal raphe, the epiglottis, and the thyroid cartilage [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Anatomy of inferior end of palatopharyngeus: its contribution to upper esophageal sphincter opening

Fukino

Tsutsumi

Nimura

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose The palatopharyngeus is one of the longitudinal pharyngeal muscles which contributes to swallowing. It is reported that the palatopharyngeus has muscle bundles in various directions and with attachment sites, and each muscle bundle has a specific function. Although previous reports suggest that the palatopharyngeus is partly interlaced with some parts of the inferior constrictor, the precise relationship remains unclear. The purpose of this study was to examine the precise manner of the connection between the palatopharyngeus and inferior constrictor, and to examine the histological characteristics of this connection. Methods We examined 15 halves of nine heads from Japanese cadavers (average age: 76.1 years); 12 halves, macroscopically, and three halves, histologically. Results Our observation suggests that the palatopharyngeus spreads radially on the inner aspect of the pharyngeal wall. The most inferior portion of the palatopharyngeus extended to the inner surface of the cricopharyngeal part of the inferior constrictor. Histological analysis showed that the inferior end of the palatopharyngeus continued into the dense connective tissue located at the level of the cricoid cartilage. The dense connective tissue not only covered the inner surface of the inferior constrictor but also entered its muscle bundles and enveloped them. Conclusion Therefore, the palatopharyngeus interlaced the cricopharyngeal part of the inferior constrictor through the dense connective tissues. The findings of this study show that the palatopharyngeus may act on the upper esophageal sphincter directly and help in its opening with the aid of the pulling forces in the superolateral direction.

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Esophagus‐Inspired Actuator for Solid Transportation via the Synergy of Lubrication and Contractile Deformation

Liu

Zhang

et al. 2021

Advanced Science

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Directional transportation of objects has important applications from energy transfer and intelligent robots to biomedical devices. Although breakthroughs in liquid migration on 2D surfaces or 3D tubular devices have been achieved, realizing smooth/on‐demand transportation of constrained solids within a 3D cavity environment under harsh pressurized environment still remains a daunting challenge, where strong interface friction force becomes the main obstacle restricting the movement of solids. Inspired by typical feeding mechanism in natural esophagus system which synergistically couples a lubricating mucosa surface with the peristaltic contraction deformation of the cavity, herein, this challenge is addressed by constructing an esophagus‐inspired layered tubular actuator with a slippery inner surface and responsive hydrogel matrix to realize spherical solid propulsion by photo(thermo)‐induced cavity deformation. The as‐constructed tubular actuator containing Fe3O4 nanoparticles exhibits local volumetric shrinkage upon NIR‐irradiation, which can generate large hydrodynamic pressure and considerable mechanical extrusion force (Fdriving force ≈ 0.18 N) to overcome low interface friction force (ffriction force ≈ 0.03 N), enabling on‐demand transportation of constrained (pressure: 0.103 MPa) spherical solids over a long distance in an arbitrary direction. This actuator is anticipated to be used as bionic medicine transportation devices or artificial in vitro esophagus simulation systems, for example, to help formula eating‐related physiotherapy plans for patients and astronauts.

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Pharyngeal swallowing mechanics associated with upper esophageal sphincter pressure wave

Cited by 15 publications

References 29 publications

Modulation of pharyngeal swallowing by bolus volume and viscosity

Modulation of pharyngeal swallowing by bolus volume and viscosity

Anatomy of inferior end of palatopharyngeus: its contribution to upper esophageal sphincter opening

Esophagus‐Inspired Actuator for Solid Transportation via the Synergy of Lubrication and Contractile Deformation

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