Phase-1 bioactivation mechanisms of aflatoxin through AhR, CAR and PXR nuclear receptors and the interactions with Nigella sativa seeds and thymoquinone in broilers

Ateş, Mehmet Burak; Ortatatli, Mustafa

doi:10.1016/j.ecoenv.2020.111774

Cited by 17 publications

(9 citation statements)

References 38 publications

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“…Researchers noted that many extracts from herbs and plants can prevent AFB1 toxicity [22,23]. Curcumin, Curcuma longa L., is a popular spice and food additive widely used in South Asian and Middle Eastern countries [24].…”

Section: Introductionmentioning

confidence: 99%

The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1

Hatipoğlu

Keskin

2022

Heliyon

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Section: Introductionmentioning

confidence: 99%

The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1

Hatipoğlu

Keskin

2022

Heliyon

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“…AFs contaminated bread induced genotoxicity and histopathological lesions that were observed in the liver and kidney, as shown in the current and previous studies [22][23][24][25][26] . The liver is the most affected organ by AFB1 [9] . Histological anomalies resulting from AFB1 toxicity in the liver leads to malfunctioning represented by disturbed lipid metabolism, lipid accumulation in the liver, and elevated hepatocyte apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…The liver is the principal target organ for AFs [9] . Several reports have shown that other organs are affected by the toxicity of AFs like kidney [10] , and lung [11] .…”

Section: Introductionmentioning

confidence: 99%

The Ameliorative Effect of Turmeric Against Aflatoxin Toxicity in Male Albino Rats Fed on Mouldy

Mahmoud

Helaly

El-Dash

2022

Egyptian Journal of Zoology

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Moulds are found in many foodstuffs and produce toxic substances known as mycotoxins which are dangerous to the human health and livestock. Aflatoxins (AFs) are the most important mycotoxins affecting the human health and trade in the world. There is an inevitable exposure to AFs in developing countries. The current study aimed to investigate the ameliorative role of turmeric (tur) against AFs toxicity in adult male albino rats (Rattus norvegicus) fed on mouldy bread. Twenty-four rats were equally allotted into 4 groups: GpI (control group: fed on dry normal bread), GpII (mouldy bread group: fed on mouldy bread), GpIII (fed on normal bread + 60 mg tur/kg body weight/day), and GpIV (fed on mouldy bread + 60 mg tur/kg body weight/day). Total AFs concentration was measured in mouldy bread, and accordingly the daily dose of AFs was 0.272 mg/kg body weight of rat. After 30 days, the effect of tur on AFs toxicity was evaluated by investigating the activity of aminotransferases, kidney function, lipid profile, and glucose level in serum, as well as genotoxicity and histopathological alterations. Feeding rats with mouldy bread containing AFs led to a significant increase in the activities of serum aspartate and alanine aminotransferases, the concentrations of serum creatinine, urea, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, and glucose, as well as genotoxicity in bone marrow cells and histopathological lesions in the liver and kidneys tissues. However, tur supplementation alleviated significantly almost all the above-mentioned harmful effects of AFs.

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“…In broilers, the effects of mycotoxins on AhR signaling pathway-related genes have been investigated by a limited number of studies. In particular, AhR and CYP enzyme expression levels were increased by the ingestion of aflatoxin [ 11 , 42 ] and T-2 toxin [ 43 ] in the chicken liver. However, there is scarce information regarding the effects of DON and FUM on AhR metabolic pathway-related genes across the broiler intestine [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Deoxynivalenol and Fumonisins on Broiler Gut Cytoprotective Capacity

Paraskeuas

Griela

Bouziotis

et al. 2021

Toxins

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Mycotoxins are a crucial problem for poultry production worldwide. Two of the most frequently found mycotoxins in feedstuffs are deoxynivalenol (DON) and fumonisins (FUM) which adversely affect gut health and poultry performance. The current knowledge on DON and FUM effects on broiler responses relevant for gut detoxification, antioxidant capacity, and health is still unclear. The aim of this study was to assess a range of selected molecular intestinal biomarkers for their responsiveness to the maximum allowable European Union dietary levels for DON (5 mg/kg) and FUM (20 mg/kg) in broilers. For the experimental purpose, a challenge diet was formulated, and biomarkers relevant for detoxification, antioxidant response, stress, inflammation, and integrity were profiled across the broiler intestine. The results reveal that DON significantly (p < 0.05) induced aryl hydrocarbon receptor (AhR) and cytochrome P450 enzyme (CYP) expression mainly at the duodenum. Moreover, DON and FUM had specific significant (p < 0.05) effects on the antioxidant response, stress, inflammation, and integrity depending on the intestinal segment. Consequently, broiler molecular responses to DON and FUM assessed via a powerful palette of biomarkers were shown to be mycotoxin and intestinal site specific. The study findings could be highly relevant for assessing various dietary bioactive components for protection against mycotoxins.

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Phase-1 bioactivation mechanisms of aflatoxin through AhR, CAR and PXR nuclear receptors and the interactions with Nigella sativa seeds and thymoquinone in broilers

Cited by 17 publications

References 38 publications

The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1

The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1

The Ameliorative Effect of Turmeric Against Aflatoxin Toxicity in Male Albino Rats Fed on Mouldy

Effects of Deoxynivalenol and Fumonisins on Broiler Gut Cytoprotective Capacity

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