Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

Abstract

Bortezomib selectively binds and inhibits the 20S proteasome enzyme’s active sites. This study was conducted to determine the side effects and maximum tolerated dose (MTD) of bortezomib in patients with recurrent malignant glioma. Separate dose escalations were conducted in patients taking or not taking enzyme-inducing anti-seizure drugs (+/−EIASD). The starting dose in both groups was 0.9 mg/m2 intravenously twice weekly for the first three of each 4 week cycle. Imaging assessment of response was carried out and Plasma 20S proteasome activity inhibition and imaging was conducted to monitor efficacy. The 66 patients enrolled had a median age of 51 years, median KPS of 90%, and 77% had glioblastoma multiforme. The MTD in the −EIASD group was 1.70 mg/m2 based on grade 3 thrombocytopenia, sensory neuropathy and fatigue. In the +EIASD group escalation was terminated at 2.5 mg/m2 without meeting meet the MTD criteria. However, proteasome inhibition in this group did not change at doses above 1.90 mg/m2 suggesting that further escalations would be unlikely to increase a biologic effect. Mean proteasome inhibition plateaued in +EIASD patients receiving 2.1 mg/m2 of bortezomib at 77 ± 12% and in −EIASD patients treated with a dose of 1.7 mg/m2 at 79 ± 6%. Two partial responses were observed. This study determined that EIASDs effect the MTD of bortezomib and the dose required for maximal inhibition of whole blood 20S proteasome. Some evidence of clinical activity was noted in this phase I study in patients with recurrent high grade gliomas.

A phase II trial evaluating the effects and intra-tumoral penetration of bortezomib in patients with recurrent malignant gliomas

“…It has been shown that with the degradation of IκB, the NF-κB complex translocates into the nucleus thereby stimulating specific gene expression, survival factors, and insulin-like PFS-6 was 56 % with a best response of stable disease (SD). In another phase I trial in recurrent MG, treatment was given on days 1, 4, 8 and 11 of weeks 1 and 2 of a 3 week cycle with an MTD of 1.7 mg/m 2 in patients not on EIAEDs [25]. The median OS was 5.8 months with a PFS-6 of 9 % for patients on EIAEDs and 6 months and PFS-6 of 21 % if not on EIAEDS.…”

Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas

“…243 These include mTOR inhibitors (temsirolimus, 244,245 everolimus 246 and AP23573), bortezomib 247,248 and protein kinase C (PKC) inhibitors. 229 Of particular interest in this group is enzastaurin (Eli Lilly, Indianapolis, IN, USA) which is a selective PKCb inhibitor.…”

Central Nervous System Multiple Myeloma

“…Additionally a recent phase I trial in which bortezomib was used in glioblastoma patients seems to confirm this. 8 Finally, at a more recent follow-up, 1 of our patients (treated with bortezomib-dexamethasone and radiotherapy), was still alive at 50 months from diagnosis.…”