Phase behavior of aqueous systems of monoglycerides

Lutton, Évelyne

doi:10.1007/bf02636909

Cited by 228 publications

(133 citation statements)

References 7 publications

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“…7b is 2.1. This property µ is given by [3] where α represents the flexibility of the stress carrying unit and D f is the fractal dimension. For stiff chains α is expected to be about 2, while for flexible chains it can go up to 5 (25).…”

Section: Concentration Dependence Of the Coagel Network Strengthmentioning

confidence: 99%

Rheological Characterization, Crystallization, and Gelation Behavior of Monoglyceride Gels

Sein

Verheij

Agterof

2002

Journal of Colloid and Interface Science

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Section: Concentration Dependence Of the Coagel Network Strengthmentioning

confidence: 99%

Rheological Characterization, Crystallization, and Gelation Behavior of Monoglyceride Gels

Sein

Verheij

Agterof

2002

Journal of Colloid and Interface Science

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“…The near 100% loading and entrapment efficiencies of PTX in this formulation are attributed to the self-emulsifying properties of GMO. Monoglycerides, like GMO, are polar lipids with poor water solubility that exhibit properties that resemble non-ionic surfactants that have been comprehensively described (33).…”

Section: Nanoparticle Characterizationmentioning

confidence: 99%

A Novel Nanoparticle Formulation for Sustained Paclitaxel Delivery

2008

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Purpose. To develop a novel nanoparticle drug delivery system consisting of chitosan and glyceryl monooleate (GMO) for the delivery of a wide variety of therapeutics including paclitaxel. Methods. Chitosan/GMO nanoparticles were prepared by multiple emulsion (o/w/o) solvent evaporation methods. Particle size and surface charge were determined. The morphological characteristics and cellular adhesion were evaluated with surface or transmission electron microscopy methods. The drug loading, encapsulation efficiency, in vitro release and cellular uptake were determined using HPLC methods. The safety and efficacy were evaluated by MTT cytotoxicity assay in human breast cancer cells (MDA-MB-231).Results. These studies provide conceptual proof that chitosan/GMO can form polycationic nano-sized particles (400 to 700 nm). The formulation demonstrates high yields (98 to 100%) and similar entrapment efficiencies. The lyophilized powder can be stored and easily be resuspended in an aqueous matrix. The nanoparticles have a hydrophobic inner-core with a hydrophilic coating that exhibits a significant positive charge and sustained release characteristics. This novel nanoparticle formulation shows evidence of mucoadhesive properties; a fourfold increased cellular uptake and a 1000-fold reduction in the IC 50 of PTX. Conclusion. These advantages allow lower doses of PTX to achieve a therapeutic effect, thus presumably minimizing the adverse side effects.

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“…Monoglycerides are polar lipids with poor water solubility that exhibit aqueous phase behavior reflecting their structural similarity to non-ionic surfactants. 17) Landh and Larsson have patented the preparation of colloidal dispersions of nonlamellar ly-otropic crystalline phases and have termed the particles "cubosomes". 18) Cubosomes usually have been produced by means of time-consuming methods involving high-energy input.…”

mentioning

confidence: 99%

Cubosomes: An Overview

Garg

Saraf

2007

Biological & Pharmaceutical Bulletin

236

151

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Surfactant and polymers are generally used in the controlled drug delivery systems. Surfactant and polymer systems form supra-assemblies, which are extensively exploited as active delivery vehicles. These systems include liquid crystalline aggregates (e.g., liposomes and cubosomes) or cross-linked gel networks (hydrogels) that load, stabilize, and eventually deliver active ingredients. The potential for utilizing a particular active with a vehicle depends on the physicochemical properties of both. To achieve therapeutic effects, it must be possible to load sufficient amounts of the active, which largely depends on the interaction of the vehicle and active. Further, the integrity of the active must be retained through all stages: preparation, storage, and use. The release rate of actives must be controlled to achieve optimal drug release profiles, while ease of preparation and vehicle stability must also be considered. An optimal delivery vehicle must successfully encompass all these properties.Cubosomes are bicontinuous cubic phase liquid crystals have many properties that make them appealing as a universal vehicle for drug delivery. Luzzati et al. 1) first documented its geometric model supplied later by Scriven.2) Which is in the past decade have been examined for drug delivery.3) The surfactant assembles into bilayers that are twisted into a three dimension, periodic, minimal surface forming tightly packed structure, like "honeycombed" with bicontinuous domains of water and lipid.Cubosome particles are first prepared by mechanical fragmentation of the cubic lipid-water phase in a three-phase region containing a liposomal dispersion and to differentiate from liposomes, these particles have been termed as cubosomes. [4][5][6][7][8] Its structure is different from liposomes because its structure can simultaneously accommodate water-soluble, lipid-soluble, and amphiphilic molecules.Three structure of cubosomes have been proposed by Luzzati et al. 9); (i) Pn3m (D-surface) (Diamond surface), (ii) Ia3d (G-surface) (Gyroid surface), and (iii) Im3m (P-surface) (Primitive surface), in terms of nodal surfaces.The structure generally maintains the efficacy; stability of actives such as vitamins 10) and proteins. 11) Cubosomes are thermodynamically stable; lasting indefinitely.12) Colloidal dispersions of cubosomes can be stabilized by the addition of polymers.13) They also possess the potential for controlled delivery of actives, where diffusion is governed by the tortuous diffusion of the active through the "regular" channel structure of the cubic phase.14) Cubosomes possess a sufficient average degree of molecular orientation order to characterize by structural symmetry, and often form in aqueous surfactant system at relatively high ampiphile concentrations.History Luzzati and Husson 15) and Luzzati et al. first recognized the existence of cubic phases in lipid-water system using X-ray scattering measurement. Fontell et al. 16) drew similar conclusions regarding cubic phase in ternary systems of ampiphiles, oils and ...

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Phase behavior of aqueous systems of monoglycerides

Cited by 228 publications

References 7 publications

Rheological Characterization, Crystallization, and Gelation Behavior of Monoglyceride Gels

Rheological Characterization, Crystallization, and Gelation Behavior of Monoglyceride Gels

A Novel Nanoparticle Formulation for Sustained Paclitaxel Delivery

Cubosomes: An Overview

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