Phase behavior of phospholipid-based myelin figures influenced by pH

Three-Dimensional Imaging of Bioinspired Lipidic Mesophases Using Multicolored Light-Emitting Carbon Nanodots

“…The diameters of the DMPC-based MFs were measured at acidic and neutral pH. In accordance with the earlier studies, 16 larger diameter tubes were formed by lowering the initial pH of the aqueous phase. This relationship is attributed to the protonation of the phosphate group (p K a < 2) 54 within the lipid headgroup.…”

“…Lipids are known to self-assemble into lyotropic mesophases, vital for biologically relevant entities. − A prominent example of a lamellar liquid crystalline system of a biological origin is the myelin figure (MF). − This structure resembles the lipid-rich myelin sheath, enabling the efficient conduction of nerve impulses in vertebrates. , Typically, MFs are multilamellar cylindrical structures of self-organized concentrically wrapped layers of amphiphiles (e.g., lipids, as well as ionic and nonionic surfactants) alternating with layers of water. − Such three-dimensional (3D) organization can spontaneously occur once surfactant molecules combine with aqueous media. A deeper comprehension of the architecture, stability, and response to external stimuli of lipidic liquid crystalline materials may lead to a better understanding of native structures and advances in the design of biomimetic systems. ,− …”

“…A deeper comprehension of the architecture, stability, and response to external stimuli of lipidic liquid crystalline materials may lead to a better understanding of native structures and advances in the design of biomimetic systems. 4 , 16 − 20 …”