Phase-changeable nanoparticles loaded with FeⅢ-tannic acid/paclitaxel for retinoblastoma treatment

B, Li; Du, Yangrui; Xiao, Qibin; Chen, Xiaoli; Liu, Zhongshun; Du, Zhiyu

doi:10.1016/j.jddst.2022.103989

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Meanwhile, PFP has a boiling point of 29 °C, theoretically making it liquid at room temperature but gaseous at body temperature. 42,45 However, the temperature at which the nanoparticles undergo phase change was increased upon their encapsulation by PLGA shell. Previous research has demonstrated that smaller particle sizes necessitate higher temperatures for phase transition.…”

Section: Nir and Us Imaging Of The Opn@pfp-dir Nps In Vivomentioning

confidence: 99%

A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis

Zhao,

Qin,

Wang

et al. 2024

Nanoscale Adv.

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Section: Nir and Us Imaging Of The Opn@pfp-dir Nps In Vivomentioning

confidence: 99%

A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis

Zhao,

Qin,

Wang

et al. 2024

Nanoscale Adv.

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“…PTT employs plasmonic metallic nanosystems or NIR dye, which convert the incident NIR light into light, thereby causing a localized ablation of the tumor cells [ 18 , 19 , 20 ]. Several studies have reported the use of photothermal therapy for the treatment of retinoblastoma [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. However, recent literature reports reveal that the tumor cells acquire inherent resistance to the heat that is induced via PTT through the activation of heat shock proteins (HSP).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Polymeric Nanoparticles of Moringa oleifera Induced Phyto-Photothermal Sensitization for the Enhanced Therapy of Retinoblastoma

et al. 2023

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Treatment of retinoblastoma is limited due to its delayed detection and inaccesbility of drugs to reach the retina crossing the blood-retinal barrier. With the advancements in nanotechnology, photothermal therapy (PTT) employing plasmonic nanomaterials and/or NIR dyes have emerged as an affordable alternative owing to the spatial control that is offered by the modality leading to localized and enhanced therapeutic efficacy with minimal invasiveness. However, the modality is limited in its clinical application owing to the increased heat shock resistance of the tumor cells in response to the heat that is generated via PTT. Hence, in this study, we explore the role of novel biomolecular fraction of Moringa oleifera (DFM) encapsulated within a polymeric nanosystem, for its anti-heat shock protein (HSP) activity. The MO extract was co-encapsulated with NIR sensitizing dye, IR820 into a biodegradable polycaprolactone (PCL) nano-delivery system (PMIR NPs). The photothermal transduction efficacy of PMIR NPs was validated in vitro against retinoblastoma cell lines. The inherent fluorescence of DFM was utilized to evaluate the cellular internalization of the PMIR NPs using fluorescence microscopy and flow cytometry. The overall oxidative protein damage and downregulation of HSP70 expression upon treatment with PMIR NPs and NIR laser irradiation was evaluated using densiometric protein analysis and Western blotting. Overall, the PMIR NPs exhibited excellent anti-cancer activity when combined with PTT with downregulated HSP70 expression against retinoblastoma cells.

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Phase-changeable nanoparticles loaded with FeⅢ-tannic acid/paclitaxel for retinoblastoma treatment

Cited by 2 publications

References 10 publications

A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis

A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis

Bioactive Polymeric Nanoparticles of Moringa oleifera Induced Phyto-Photothermal Sensitization for the Enhanced Therapy of Retinoblastoma

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