Phase-contrast imaging of a soft biological object using X-pinch as X-ray source

Liu, R.; Wang, X. X.; Zou, Xiaobing; Zeng, Naigong; He, Lugui

doi:10.1209/0295-5075/83/25002

Cited by 12 publications

(5 citation statements)

References 15 publications

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“…X-pinch studies at the 0.2-0.5-MA current level have been carried out in many laboratories worldwide. Various results on the X-pinch evolution [3]- [5], X-ray spectroscopy from X-pinches [6], [7], and X-ray backlighting using X-pinches [8]- [11] have been published.…”

Section: X-pinchmentioning

confidence: 99%

$X$-Pinch Experiments on 1-MA “QiangGuang-1” Facility

Qiu

et al. 2010

IEEE Trans. Plasma Sci.

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The results of an experimental investigation of X -pinch performance on the 1-MA "QiangGuang-1" facility are presented. "QiangGuang-1" is a linear-transformer-driver-based low-impedance pulsed power machine which provides a peak current of 0.9-1.3 MA and a 10%-90% rise time of 50-60 ns. X -pinch loads with 2-32 wires of different wire materials (Al, W, and Mo) with wire diameters from 25 to 100 μm have been tested. The number and size of bright spots, timing of the first X-ray burst, X -pinch dynamics, and X-ray spectroscopy have been studied using a set of diagnostics with spatial and/or temporal resolution. A single bright spot obtained from a 30 × 25 μm W X -pinch produced 42 J (35 GW) in the 1-10-keV energy range. The smallest bright spot size (radiating > 1.2 keV) observed was about 70 μm. Linear relations between the timing of the first X-ray burst and the wire parameters (diameter and number) in W X -pinches were observed. A spatially large extreme ultraviolet plasma radiation region at the crossing point was typically observed. Al X -pinch plasma parameters were estimated from X-ray spectroscopy.Index Terms-Plasma diagnostics, pulse power, X -pinch, X-ray spectroscopy.

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Section: X-pinchmentioning

confidence: 99%

$X$-Pinch Experiments on 1-MA “QiangGuang-1” Facility

Qiu

et al. 2010

IEEE Trans. Plasma Sci.

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“…Currently, there are limited clinical applications for SR imaging, and it remains predominantly a research tool. More recently, the technological advances in SR sources as well as new compact x-ray sources with high brightness, such as the liquid-metal-jet anode electron-impact x-ray sources [ 35 ], the plasma-based x-ray source [ 36 ], and the quasi-monochromatic tunable inverse Compton scattering x-ray sources [ 37 ], have made possible the practical implementation of PCI. These new approaches have great capacity to improve soft tissue contrast compared to conventional absorption-based x-ray imaging techniques in many clinical applications [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Are Human Peripheral Nerves Sensitive to X-Ray Imaging?

et al. 2015

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Diagnostic imaging techniques play an important role in assessing the exact location, cause, and extent of a nerve lesion, thus allowing clinicians to diagnose and manage more effectively a variety of pathological conditions, such as entrapment syndromes, traumatic injuries, and space-occupying lesions. Ultrasound and nuclear magnetic resonance imaging are becoming useful methods for this purpose, but they still lack spatial resolution. In this regard, recent phase contrast x-ray imaging experiments of peripheral nerve allowed the visualization of each nerve fiber surrounded by its myelin sheath as clearly as optical microscopy. In the present study, we attempted to produce high-resolution x-ray phase contrast images of a human sciatic nerve by using synchrotron radiation propagation-based imaging. The images showed high contrast and high spatial resolution, allowing clear identification of each fascicle structure and surrounding connective tissue. The outstanding result is the detection of such structures by phase contrast x-ray tomography of a thick human sciatic nerve section. This may further enable the identification of diverse pathological patterns, such as Wallerian degeneration, hypertrophic neuropathy, inflammatory infiltration, leprosy neuropathy and amyloid deposits. To the best of our knowledge, this is the first successful phase contrast x-ray imaging experiment of a human peripheral nerve sample. Our long-term goal is to develop peripheral nerve imaging methods that could supersede biopsy procedures.

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“…Pulsed-power plasma devices loaded as Z-pinch, X-pinch, wire arrays, or liners have the ability to reproduce a vast variety of plasmas, such as dense plasmas for fusion studies, laboratory astrophysics plasmas, dense and hot point-source plasmas for hard X-ray generation, and lower density hot plasmas. Since the first realization by Zakharov et al [1], X-pinch plasmas driven by pulsed-power machines have been efficiently used as brightpoint sources for X-ray radiation in applications such as point-projection radiography of plasmas [2,3], X-ray microscopy for biological samples [3][4][5], and inertial confinement fusion capsules [6]. The small size of these devices and the predictable location of the radiation source [7] also make them favorable for applications such as X-ray backlighting [8] and microlithography [9].…”

Section: Introductionmentioning

confidence: 99%

Characterization of an X-ray Source Generated by a Portable Low-Current X-Pinch

et al. 2021

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An X-pinch scheme of a low-current generator (45 kA, 50 ns rise time) is characterized as a potential efficient source of soft X-rays. The X-pinch target consists of wires of 5 μm in diameter—made from either tungsten (W) or gold (Au)-plated W—loaded at two angles of 55° and 98° between the crossed wires. Time-resolved soft X-ray emission measurements are performed to provide a secure correlation with the optical probing results. A reconstruction of the actual photodiode current profile procedure was adopted, capable of overcoming the limits of the slow rising and falling times due to the “slow” response of the diodes and the noise. The pure and Au-plated W deliver an average X-ray yield, which depends only on the angle of the crossed wires, and is measured to be ~50 mJ and ~70 mJ for the 98° and 55° crossed wire angles, respectively. An additional experimental setup was developed to characterize the X-pinch as a source of X-rays with energy higher than ~6 keV, via time-integrated measurements. The X-ray emission spectrum was found to have an upper limit at 13 keV for the Au-plated W configuration at 55°. The portable tabletop X-pinch proved to be ideal for use in X-ray radiography applications, such as the detection of interior defects in biological samples.

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Phase-contrast imaging of a soft biological object using X-pinch as X-ray source

Cited by 12 publications

References 15 publications

$X$-Pinch Experiments on 1-MA “QiangGuang-1” Facility

$X$-Pinch Experiments on 1-MA “QiangGuang-1” Facility

Are Human Peripheral Nerves Sensitive to X-Ray Imaging?

Characterization of an X-ray Source Generated by a Portable Low-Current X-Pinch

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