2016
DOI: 10.1021/acs.macromol.6b01198
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Phase Controllable Hyaluronic Acid Hydrogel with Iron(III) Ion–Catechol Induced Dual Cross-Linking by Utilizing the Gap of Gelation Kinetics

Abstract: Metal complexation-based gelation imparts load-bearing hydrogels with striking properties like reversibility, self-healing, and mechanical tunability. Using a bio-inspired metal−catechol complex, these properties have been introduced to a variety of polymer hydrogels, except hyaluronic acid, which is widely used in biological applications. In this research, we developed two different hyaluronic acid (HA) hydrogels by regulating the gelation kinetics of Fe 3+ and a catechol cross-linker, including Fe 3+ -induce… Show more

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Cited by 102 publications
(86 citation statements)
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“…As shown in Figure 1c, PL‐Cat alone showed no Raman activity. After adding Fe 3+ , the solution turned to acidic (PL‐Cat/Fe [pH ≈ 2.0]) and only a very weak signal was observed, [ 25 ] indicating that PL‐Cat was not prone to coordinating with Fe 3+ in acidic conditions. When the pH of the solution was adjusted to ≈5, weak peaks were observed around 531–637 and 1270–1483 cm −1 , indicating the coordination of PL‐Cat and Fe 3+ .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…As shown in Figure 1c, PL‐Cat alone showed no Raman activity. After adding Fe 3+ , the solution turned to acidic (PL‐Cat/Fe [pH ≈ 2.0]) and only a very weak signal was observed, [ 25 ] indicating that PL‐Cat was not prone to coordinating with Fe 3+ in acidic conditions. When the pH of the solution was adjusted to ≈5, weak peaks were observed around 531–637 and 1270–1483 cm −1 , indicating the coordination of PL‐Cat and Fe 3+ .…”
Section: Resultsmentioning
confidence: 99%
“…When the pH of the solution was adjusted to ≈5, weak peaks were observed around 531–637 and 1270–1483 cm −1 , indicating the coordination of PL‐Cat and Fe 3+ . [ 25 ] However, no obvious peak at 531 cm −1 , the peak indicating the charge transfer (CT) interaction of bidentate chelate, [ 24 ] was detected, which demonstrated that at this pH (≈5), the most coordination between catechol and Fe 3+ was the weak mono‐complex. [ 24 ] After mixing it with a weak basic ODex solution, the pH of the PL‐Cat/Fe/ODex solution can be adjusted to 7.4 or 8.5, accompanied by the formation of the hydrogel.…”
Section: Resultsmentioning
confidence: 99%
“…The central factor for the formation of transparent hydrogel was supposed to be the hydrophobicity of catechol, which changed the solubility of the whole polymer chain. However, changing color from yellow to red was accompanied by the addition of NaOH, and the fact that the oxidation of catechol made this process of some potential interest …”
Section: Resultsmentioning
confidence: 99%
“…They found that the formed metal–ligand interactions and sacrificial bonds, especially between amino acid ligands and Fe(III) ions, effectively increased the stiffness and strength of the materials without sacrificing the extensibility. Following these works, several other contributions utilizing the catechol–metal complexation as underwater self-healing adhesives have emerged [59,60,61,62,63,64,65,66,67,68].…”
Section: Self-healing Materials Based On Dopamentioning
confidence: 99%